Study sheds light on cause of an AIDS treatment side effect
... patients." It is not unusual to find that a drug acts on a different target than the one it was designed to affect, which is why there are often side effects from drugs. "This finding that protease inhibitors affect MPP could be useful if one wants to develop inhibitors of MPP for other conditions, such...Study finds outbreak of Cipro web sites followed anthrax outbreak
...c like ciprofloxacin." Most state medical practice acts stipulate that a physician must examine a patient before prescribing a medication. However, none of the Web sites in the CWRU study required the customer to mail or fax in a physician's prescription. Forty-nine sites (81 percent) simply asked the cus...Using naltrexone to treat alcoholics with a 'Mediterranean drinking pattern'
...oduced outside the organism) chemical. Naltrexone acts as an opioid antagonist within the opioid neurotransmitter system, which is a part of the brain's reward system. When opioids are stimulated, levels of the dopamine neurotransmitter are increased, leading to the "high" that is associated with a vari...Vitamin E fails to join heart-health regimen
...ditional benefit." Also, though vitamin E clearly acts as an anti-oxidant within the blood, it may not have the same effects within the tissue of the artery wall, where it would be most important, Hodis says. Its mechanisms need further study. Vitamin E showed no negative health effects in the study. For...New drug may help recovering cocaine addicts, study shows
...r to the popular antidepressant Paxil, although it acts on different neurotransmitters. "Our studies have shown that Nocaine would likely blunt the aversive effects associated with cocaine abstinence, enabling addicts to gradually and safely withdraw from the drug," said Alan P. Kozikowski, PhD, professor...U-M Bioterrorism Preparedness Initiative gets $1 million from CDC
...isease outbreaks, be they a result of bioterrorist acts or naturally occurring. This grant will move us well down the road toward the goal," said Noreen Clark, dean of the U-M School of Public Health and chair of the U-M Bioterrorism Preparedness Initiative's advisory council. Training efforts will target...Stanford researchers test drug to fight depression faster in elderly
...ts of serotonin and other brain chemicals and also acts as a mild sedative. Schatzberg tested mirtazapine's effectiveness against paroxetine (sold under the name Paxil), a popular SSRI. In his trial, 255 depressed people 65 or older were randomly divided into groups taking either mirtazapine or pa...New information scheme reassures patients
...s of concern to the patient. A medical oncologist acts as a referee co-ordinator of the PIS. Dr Passalacqua's team tested the efficacy of this new structure by means of a randomised trial in 38 cancer centres all over Italy by comparing the centres with a PIS with a control group. The result was measure...Prostate cancer program at UCLAs Jonsson Cancer Center designated a site of research excellence
...whose prostate cancer cells lack PTEN, a gene that acts like a switch regulating access to a cell-signaling pathway. UCLA researchers have discovered that cells lacking PTEN are more sensitive to rapamycin. About 20 percent of men with prostate cancer lack the PTEN gene. The study also seeks to develop an...Cholesterol drug could lead to new therapy for multiple sclerosis
...tudy, the researchers determined that atorvastatin acts by interrupting the inflammatory process. In the m...ill be learning even more precisely how atorvastin acts in the immune system. "We want to see what happens to really get to the bottom of this." Co-authors...Domestic violence levels high in rural Uganda
...hreats or abuse experienced three or more specific acts of violence during the previous year. Nearly 50 percent reported receiving injuries as a result. Female to male domestic violence was less common. Five percent of women in the study said they had physically threatened or assaulted their male partners...New biological sensors for detecting blood glucose developed by Hebrew University, U.S. Scientists
...e enzyme glucose oxidase, like most other enzymes, acts as an insulator when binding to a conductive surfa...noparticle is implanted into the enzyme, the gold acts as an electrical "plug," facilitating the flow of electrons to the attached electrode and the oxidat...Rice uses buckyballs to reinvent 'antibiotic of last resort'
... molecules joined by an intermediate molecule that acts as a bridge -- some of which have proven more effective at killing resistant bacteria. Rice Chemistry Professor Lon Wilson decided to create a buckyball-vancomycin conjugate following years of work developing biochemical targeting mechanisms for buck...Study suggests bipolar disorder may cause progressive brain damage
...onal proteins, and is a precursor of myelin, which acts as insulation around neurons in the brain. "Low NAA is an indication that the integrity of neurons and/or axons has been compromised in some way, either by damage, loss or dysfunction," Deicken said. The decrease of hippocampal NAA over time in the t...Smart virus eliminates brain cancer in animal experiments
...ein. Found in all cells of the body, an Rb protein acts like a brake on cell division by preventing certain other regulatory proteins from triggering DNA replication. If the Rb protein is missing or non-functioning, a cell can replicate itself over and over, resulting in the development of a tumor. In no...Latest research on possible causes of violent behavior explored in C&EN article
...m. Serotinin is neurotransmitter in the brain that acts as a kind of brake on impulsiveness. People with ...ully to cut the number and intensity of aggressive acts committed by impulsive convicts, reports Ernest S. Barratt, Ph.D., a professor of psychiatry and beh...9/11 boosted trust in government, temporary distress, research shows
...tions helped steer adolescents away from unhealthy acts such as drug and tobacco use and early sexual activity. A UNC report published in 2000 showed that pledges some adolescents take to delay sexual activity until marriage -- sometimes called "virginity pledges" -- tend to work when groups making the pl...Physics and medicine in San Diego
...scatter of incident radiation, the barium compound acts as an internal shield that absorbs errant radiation. A study that simulated a CT scan of a pregnant woman showed that ingesting a 40 percent solution of barium sulfate would decrease the fetal dose to a negligible level, so that even high-quality CT...Single protein is key in response to bacterial, viral infections
A single protein acts as a key switch point in frontline immune system reactions to both bacterial and viral infections, according to a report published online today in the journal Nature. In determining how this protein functions, a team of scientists supported by the Na...Estrogen replacement increases risk factors for arrhythmia and sudden death
...Carnethon said it is possible that hormone therapy acts to lengthen QT intervals and increase risk for arrhythmia, heart attack and sudden death. This research represents the largest observational study of postmenopausal women with the longest follow-up to date to estimate the effects of hormone therapy ...