Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...se micethat lacked the leptin protein, researchers administered leptin to one groupand a saline placebo to the other group. Because the genetically obese miceproduced no natural leptin, it was easier to track the effects of the artificialleptin. Results of the study showed that leptin does, in fact, signal the s...Nasal Spray Flu Vaccine By U-M Researcher Is 93% Effective
...nal dead virus vaccine. Andsecond, the vaccine is administered in a nasal spray that the children in thestudy "much preferred." "The tri-valent vaccine contains two different A influenza strains and oneB strain, and protected children from both the A and B strains circulating lastyear," Maassab said. ...New Approach To Multidrug Resistance
... the cancer drugmitomycin C, waited 24 hours, then administered a second chemotherapy agent. Thelow-dose pre-treatment appeared to temporarily turn off the gene that producesP-glycoprotein, producing a "window" of time during which there was an increasein the sensitivity of the cells to the killing effect of the ..."Super Aspirin" Holds Long-Term Benefits For Some Patients Who Undergo Balloon Angioplasty
...ab (ReoPro™, Centocor, Inc., Malvern, PA) administered in the catheterization laboratory before an angioplasty can prevent platelets from sticking to arterial walls and reclogging vessels after the procedure. Results of a multicenter study published in the August 13 issue of The Journal of t...Some Good News In Treating Infection Common To HIV Patients
...ents taking Bactrim do so at home. The dosages are administered orally by squirting a syringe into the mouth. Kazanjian says the desensitization regimen is now used as a part of standard clinical treatment for HIV patients with specific infections....Drug Regimen Reduces Atrial Fibrillation After Heart Surgery
... compared with 53 percent of the patients who were administered a placebo. For patients receiving amiodarone:...ar benefits can be achieved when the medication is administered in an accelerated dose over a shorter period of time." That's important because heart surgery o...Penn Researchers Initiate Ground-Breaking New Trials To Treat
...drug -- to selectively destroy tumors. The drugis administered intravenously before surgery, allowing it toconcentrate in the cancerous tissue. After surgery the patientreceives laser light exposure directed at the tissue to stimulatethe drug -- destroying the tumor cells by exposing them to anactivated form of...Research Trial To Test New Drug For Diabetic Neuropathy
...given and then at various times after the drug is administered to see if the drug is working," says Simmons. "If this phase two trial shows promising results regarding nerve conduction velocities, we would likely move to a phase three trial. That would mean not only looking for improved nerve conduction but ...Is Ritalin As Effective--And As Harmless--As It Could Be?
... effective and cause fewer side-effects if it were administered as asingle compound rather than as a mixture, say ... she said, "then fifty percent of theweight of the administered drug may not contribute to its therapeutic effects." Ding, along with colleagues Joanna S. Fowler an......dies conducted in BALB/c mice indicate that orally administered Karenitecinhad excellent antitumor activity against solid tumors (prostate, colon, breast,lung) and had superior antitumor potency compared to existing camptothecinderivatives. These results also demonstrate the ability of BioNumerik'sKarenitecins t...Widely Used Therapy May Not Be Effective In Treatment Of Acute Stroke
...e(NINDS), is the largest trial of an intravenously administered anticoagulantdrug for treatment of acute ischemic stroke. The purpose of the trial was to discover the effectiveness of LMW heparinoid(danaparoid/Org 10172) combined with conventional care in improving outcomes ofstroke patients at 7 days and at 3 mo......ostate cancer agent, butbecause it has always been administered in conjunction with hydrocortisone,itself a drug with modest anti-prostate cancer activity, its unique contributionhas been unclear. In the clinical trial, researchers determined that 43 percent of patientsreceiving suramin with hydrocortisone exper...New Radiation Procedure Targets Liver Malignancies
...gher than the dose they would have would have been administered in the previous study, and only one patient has experienced a radiation-related complication. "This is probably the most aggressive non-surgical treatment a patient can receive for liver cancer in this country," McGinn says. A paper detailing the U-...New Study Designed To Improve Outcomes In Women With Metastatic Breast Cancer
...e, called ananti-idiotypic monoclonal antibody, is administered as the second component ofthe new treatment. Deve... years. The treatment plan: Vaccine administered to stimulate immune cells Chemotherapy and growth factors stimulate stem cell growth Stem cells are ...Study Reveals Possible Clue For Racial Differences In Prevalence Of High Blood Pressure
...ces inresponsiveness to nitric oxide. Researchers administered a drug that producesnitric oxide and, again, they saw a significantly reduced response in blacks. "Blood flow increases, but significantly less than in whites, indicating theirresponse to nitric oxide is reduced," Panza says. Nitric oxide, a small m...Fact Sheet -- Rectal Administration Of Diazepam For Acute Repetitive Seizures (RADARS) Study
...y and safety of rectal diazepam gel(DiastatR) when administered by nonmedical personnel in non-acute care settings...ial for serious adverse events. Easily and safely administered by caregivers. Drug administration can be performed in most cases despite a patient'slimited abilit...Safe And Effective Treatment For Acute Repetitive Seizures
...rancisco. In addition to the new gel formulation, administered with anapplicator, diazepam is also sold in oral form. Administration of diazepam inoral form is problematic for both physicians and family members because thepatient must be alert in order to swallow. "This is a safe and effective way of addressin...Scientists Report Cancer Fighting Drug As Possible Treatment For Multiple Sclerosis
...in MS. Liedtke and co-workers found thatMMPI, when administered to such cultured human T cells, decreased the amount ofTNF-a that was shed by the cells. "With the combined impact of MMPI on human myelin autoaggressive T cells and ona powerful animal model for MS, we are looking at MMPIs as promising candidatesfo...Anti-Migraine Drugs Might Cause More Pain Than Relief For Those With Heart Disease
...to cause the coronary arteriesto contract, but are administered to patients in lower doses. The researchersdetermined the maximum contraction response of the arteries elicited by thedrugs and the concentration of the drug required to achieve half of that maximumcontraction. These values were compared to the max...Research Explains Lithium's Dual Anti-Manic/Anti-Depressive Effect
...udy the chronic effect of the lithium, the UW team administered it to livemice for two weeks. To their surprise, they saw that glutamate reuptakeincreased. This "up-regulation" resulted in less neurotransmitter in thesynapse, which would produce an anti-manic effect. "We were especially interested to find that t...