Tag: "administered" at medical news

Results of NUVANCE phase I/II asthma trial presented

...NUVANCE, 0.75 mg, 1.5 mg or 3.0 mg, to placebo and administered each treatment by inhalation once weekly for up to 12 weeks. Overall, treatment with NUVANCE was generally well tolerated. No serious adverse events related to study drug were reported. The most frequently reported side effects were headach...

Cocaine acts on central nervous system, causing vessel constriction, rapid heartbeat

...n,lead author of the paper. Investigators administered lidocaine, used here as a placebo, to sevenpatients and cocaine to seven patients in a small, medically approved,nonharmful dose. The lidocaine, like the cocaine, has a bitter taste and numbsthe nose but has no other physiological manifestations. ...

Hormone-like gel causes speedier deliveries, study suggests

...o Samuels, that PGE2 can be administered without oxytocin and, if it doesn't induce labor, a physician can re-administer the gel in a few days. "By using the prostaglandin only, we're not committing the patient to deliver...

Nausea from anesthesia plummets with extra oxygen

...ffect of using 80 percent oxygenin the gas mixture administered during anesthesia compared with the standard 30percent oxygen. In both cases, the designated oxygen level was maintained fortwo hours after surgery. The study focused on 231 patients undergoing colon surgery at two hospitals inVienna -- Donauspital-...

Medical scientists to begin clinical trials of promising cancer therapy

... killed by both the new and the old compounds when administered separately. Proscript of Cambridge, Mass., makes PS341 and related compounds. While much progress has been made in the past two decades in treating cancers like lymphoma, for example, a lot more needs to be done, Orlowski said. Currently, about h...

Seattle researchers uncover structure of blood-clotting protein involved in most common form of hemophilia

...nts of recombinant human factor VIII that could be administered one after another," Stoddard says. "When a patient develops an immune response to one, they could switch to another version of the protein. The variations could be practically endless." The researchers have filed a patent on methods of drug design, b...

Black breast cancer patients given appropriate treatment do as well as whites, finds University of Pittsburgh researcher

...o in white women at the same stage of disease when administered according to expert consensus, and that the reasons for blacks' poorer prognoses lie elsewhere," said Dr. Dignam, research assistant professor in the University's Graduate School of Public Health, and biostatistician for the National Surgical Adjuvan...

FDA advisory committee recommends approval of novantrone for treatment of worsening multiple sclerosis

... findings. NOVANTRONE, at a dose of 12 mg/m2, was administered by short IV infusion once every three months for two years. "These data demonstrate NOVANTRONE is clearly of benefit for a significant group of MS patients who currently have limited treatment options," said Hans-Peter Hartung, MD, Chairman, Departm...

Gene therapy reverses heart disease in mice

...erapy to protect against heart disease that can be administered by injection every couple of years. The most stunning finding occurred at about 200 days after treatment -- plaques in the gene-injected mice had essentially disappeared. "It has never been demonstrated that we could completely remove plaque in an a...

Estrogen shows potential as stroke treatment, UF animal studies show

GAINESVILLE, Fla.---A high dose of estrogen administered soon after a stroke can prevent a substantial amou...that researchers could test the effect of estrogen administered at 30 minutes, and one, two, three or four hours past the inducement of the stroke. A control group ...

Anti-cocaine vaccine produces antibodies and is shown to be safe in Phase 1 study conducted by Yale researcher

...al investigator on the phase 1 study, and his team administered the vaccine to 34 former cocaine abusers living in a residential treatment facility. The vaccine, TA-CD, is designed to generate drug-specific antibodies, which bind to cocaine and prevent it from traveling to the brain from the bloodstream. This ne...

New horizons, treatments in anticancer chemistry

...other microtubule-stabilizing agents are currently administered by injection or intravenously. The new agent, which appears to be especially promising for the treatment of breast and colon cancer, attacks tumors that are resistant to Taxol® and may have fewer side effects. Known as IDN5109, it is in clinical t...

Tobacco chemical protects against Parkinson's disease

.... In their study, the Virginia Tech researchers administered MPTP, a designer drug that produces a Parkinson-like disease, to laboratory rodents. Sold in the early l980s, MPTP was meant to mimic the effects of heroin. Addicts who took large doses suffered severe Parkinsonian symptoms. The naphthoquinone deriva...

Castagnolis discover compound in tobacco that may protect against Parkinson's disease

...hibitor of MAO. Using mice, the Castagnolis first administered TMN and then a potent neurotoxin, MPTP, a contaminant that had been discovered in a street drug sold in the early 1980s. The drug was meant to mimic the effects of heroin, but addicts who took large doses of the synthetic heroin suffered severe Parki...

Establishing "stroke centers" in hospitals would reduce deaths and disabilities, say stroke experts

... required. Certain clot-busting therapies must be administered within 3 hours of symptom onset for the treatments to be safe and effective. The two major goals of the stroke center recommendations are the improvement in the level of care provided to stroke patients and the standardization of some aspects of acut...

Finding offers clue to understanding addiction relapse

...rphine once a day for 10 days. The injections were administered in a cage that was different from where the animals normally lived. The cage came to represent the "drug environment." The researchers monitored the animals' motor activity, which increased with the administration of drugs. When the treated rats wer...

New drug works well as sole epilepsy therapy for difficult-to-treat patients

... U-M compared the safety and efficacy of Trileptal administered as monotherapy, the only therapy patients received. It enrolled 87 outpatients as young as 12 with inadequately controlled partial seizures, whether or not they had secondarily generalized seizures. The study included a 56-day baseline phase, during ...

AAPS workshop to explore regulatory approaches to bioavailability, bioequivalence

...pproaches to measure BA and document BE for orally administered immediate release drug products. Identify and... drug development and scientific issues for orally administered extended release drug products. Review and discuss clinical and other scientific issues and fut...

Proceedings of the National Academy of Science: animal study points to new method for halting life-threatening blood pressure decline during septis

...icals' role in septic shock came after researchers administered a MetaPhore superoxide dismutase (SOD) mimetic (M4.... However, the additional catecholamines that are administered are frequently destroyed by the huge excess of superoxide free radicals, produced as the body fights...

Baltimore researchers receive $40 million from Bill & Melinda Gates Foundation

...WHO recommends that the current measles vaccine be administered when children are at least 9 months old. "We are pleased that the Bill & Melinda Gates Foundation has asked us to take on this ambitious, five-year project. It will involve laboratory work as well as clinical testing in Africa and South America," say...

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