Tag: "agent" at medical news

New study in 'Nature' demonstrates protection against cell death during heart attack

...king cyclophilin D, it also blocks calcineurin, an agent that protects the immune system. Fortunately, there are so-called analogs of cyclosporin that block cyclophilin D but do not affect the immune system. While these drugs have not yet been tested in humans, there have been numerous studies indicating ...

Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo

...lock the action of these receptors, but use of the agent by itself has shown only modest benefits. The Food and Drug Administration approved use of Herceptin in 1998 for treatment of metastatic breast cancer in combination with chemotherapy. The long term outcome of such treatment, however, has not yet bee...

Stanford patient is first to test new treatment for peripheral arterial disease

...e clinical trial. It is coated with an anti-cancer agent called paclitaxel, which has been used on drug-eluting stents for treating coronary artery disease. "Of course, we're not treating cancer here," said Sze, "but cancer and re-narrowing of blood vessels have in common the uncontrolled growth of tissue....

Targeting mutant B-Raf protein reduces melanoma development

...6 would have to be paired with another therapeutic agent to cause the tumors to shrink or disappear," Robertson said. Of the major types of skin cancer, melanoma is the most metastatic and lethal form. It is currently the seventh most common cancer in the U.S., with about 52,000 cases diagnosed annually. ...

Scientist works on innovative treatments for brain tumors

...cancer cells will arise. "Maybe there is a better agent than IL 13 itself," said Debinski. "Nature is great, but not perfect. Sometimes, we can make it even better for the benefit of our patients." Other goals are to design tests to assist in drug development, so researchers can determine which potential ...

Government wasting your taxpayer money on ineffective drug cure

...d. More and better studies are needed before this agent is used on a wide scale basis." In January of 2003, the Centers for Medicare and Medicaid Services (CMS) initiated the national coverage determination for use of L-carnitine in qualified patients, however the criteria established for use of the drug ...

Bevacizumab combined with chemotherapy prolongs survival for some patients with advanced lung cancer

...vement in survival with the addition of a targeted agent to standard chemotherapy in this patient population," said Study Chair Alan B. Sandler, M.D., of the Vanderbilt University Medical Center in Nashville, Tenn. "This study demonstrates that mechanistic-based interventions such as angiogenesis inhibitor...

Study finds drug eluting stents as effective as vascular brachytherapy in preventing restenosis

...uting stent (SES), which releases the therapeutic agent sirolimus over time to prevent restenosis, fared at least as well as those treated with vascular brachytherapy (VB). Moreover, the patients who received the drug eluting stent had fewer cardiac events afterwards. "The efficacy of the SES in...

Study says rare allergic reactions to drug-eluting stents may raise risk for heart attack

...03, stents coated with sirolimus (a pharmaceutical agent that prevents excess tissue growth) have been shown to greatly reduce restenosis. But some people suffer from rare, allergic-type reactions to the sirolimus-eluting stents (SES). According to research presented by Emory scientists at the American C...

MRI proves useful in assessment of suspected breast cancer patients

..., while kinetics looks at how quickly the contrast agent lights up the lesion then fades away. If the lesion is bright then washes out quickly, it usually indicates cancer," he said. "By analyzing MRI using these and other factors, as well as carefully reviewing the mammograms and sonograms, we were able...

MRI better than current standard in assessing neoadjuvant chemotherapy for breast cancer

...f breast tumors would enhance with the MR contrast agent gadolinium and therefore be visible after chemotherapy. Our study found that MRI is not perfect, but it's better than what's been used as the gold standard in the past," she said. For the study, 31 patients prospectively underwent clinical examina...

Infectious microorganism linked to kidney stones and other diseases

...um phosphate centers of kidney stones. This novel agent has also been detected in related conditions, including Alzheimer's disease, heart disease, prostatitis, and some cancers. Further testing for the presence of NB in human bodies can help reduce the risk for kidney stone formation in astronauts and w...

Plant derivative attacks the roots of leukemia

... gardens across North America, is the source of an agent that kills human leukemia stem cells like no other...t is good news." Parthenolide is the first single agent known to act on myeloid leukemia at the stem-cell level, which is significant because current cancer...

Columbia study finds hemophilia therapy dramatically improves outcomes for bleeding stroke

...clinical trial ever conducted with a pharmacologic agent for the treatment of ICH. As a physician treating patients over many years with this deadly form of stroke, Dr. Mayer decided to investigate rFVIIa as a treatment for ICH after reading about its coagulation effects. With the brand name NovoSeven, r...

Diagnosis of prions in patients should utilize novel strategy, team says

...necessary to detect the minute level of infectious agent that the CDI is capable of revealing, as it would be unlikely to be lethal, says Safar. But Prusiner and his colleagues maintain that any risk is too great when it comes to having prions in the food supply. In addition, because even low levels of pri...

Resistance to chemotherapy

...s by which tumors become resistant to a particular agent is key to identifying new drugs or combination regimens. In an upcoming article in the international open-access journal PLoS Medicine , William Pao and colleagues (from the Memorial Sloan-Kettering Cancer Center in New York) shed light on what caus...

Heart attack treatment gap may be closing for women

... said. "The guidelines recommend a lipid-lowering agent with LDL of 100 mg per dL or higher." But this study reveals that progress has been made in treating patients following heart attack or who have unstable angina, she said. "More people are following the guidelines," she said. "Women are receiving ...

Component of green tea protects injured livers in mice

...how ECGC acts may suggest its use as a therapeutic agent for fatty livers used in liver transplants....

Changing chemistry helps explain estrogen threat to the heart

...trogen now had turned into a constrictor agent, an agent that would increase blood pressure." They looked further and found that normal aging decreases levels of the cofactors L-arginine and tetrahydrobiopterin both critical to nitric oxide synthase's production of nitric oxide. Instead of making nitric o...

Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study

... anti-inflammatory drug Vioxx as a chemoprevention agent found that the risk of developing a cardiovascular "event" - heart attacks and/or strokes - was almost double in patients who received the drug, compared to patients who took the placebo, according to a study out Feb. 15 on-line in The New England Jo...

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