SLU professor wins CDC grant to combat emerging infections, including West Nile
...crisis, whether intentional attack with biological agents or a naturally occurring infectious disease," said HHS Secretary Tommy Thompson....Understanding how lymph nodes respond to infection may redefine how immune system functions
...ctivation, they can specifically target infectious agents and aid the host in clearing unwanted pathogens." Abraham said the discovery that mast cells can initiate the activation and swelling of nodes through release of specific signaling molecules points to the possible use of mast cell products for the de...Brain-imaging study sheds more light on underlying cause of attention-deficit hyperactivity syndrome
...he findings may help us to develop new therapeutic agents given our knowledge of the cellular and neurochemical make-up of brain regions where we detected the greatest abnormalities."...Leading the way in novel anti-cancer research
...k also includes results from a study combining two agents developed by AstraZeneca: an epidermal growth fac...nti-tumor activity than either agent alone. These agents attack the tumor by different mechanisms. Tumor blood vessels differ significantly from normal blo...Cocoa froths with cancer-preventing compounds
... the cocoa compounds scavenge for free radicals -- agents that cause cancer, heart disease and other diseases. In the paper, the researchers discuss eating chocolate bars instead of drinking cocoa. "Although a bar of chocolate exhibits strong antioxidant activity, the health benefits are still controversi...Fosrenol shows significant reduction in serum phosphate in Chinese end-stage kidney disease patients
...it can be absorbed into the blood. Although these agents can be effective, they can cause potentially serious side effects including hypercalcemia, bone toxicity and tolerability problems. Lanthanum carbonate (FOSRENOL) Shire received an approvable letter for lanthanum carbonate on Feb. 28, 2003 from t...JCI Table of Contents, November 14, 2003
...o block the injurious effects of various injurious agents in the lung. Hyperosmolar infusion of sucrose augmented the structure of the cell cytoskeleton component, actin. An actin depolymerizing agent abrogated both the barrier enhancement as well the actin filament formation, suggesting a role for actin in...Blocking immune response to spinal cord injury can improve chances for recovery
...ormally, T-cells battle disease and other invading agents in the body, but in the central nervous system during spinal injury and periods of disease in multiple sclerosis, these T-cells create toxic compounds that attack and damage spinal tissue and nerve fibers. In tests on rats with induced spinal cord in...Women treated more aggressively for hypertension, yet results similar to men
...resting was that women received more and different agents to reduce blood pressure than did the men," Newby said. "What is confusing is that this difference in the number of drugs to control hypertension still did not have any significant effect, when compared to the men." Specifically, 16 percent of the wo...UCLA researchers to test experimental pill
...aily dose of PTK/ZK combined with the chemotherapy agents 5-fluorouracil, leucovorin and oxaliplatin, and th...l benefit of PTK/ZK combined with the chemotherapy agents 5-flurouracil, leucovorin and oxaliplatin, as compared to the chemotherapy drugs alone. PTK/ZK is a ...Drug proven to benefit heart attack victims vastly underused
...nown as glycoprotein (GP) IIb/IIIa inhibitors, are agents that block receptors on blood platelets preventing them from forming clots. Large multi-center trials have proven the inhibitors' effectiveness in preventing deaths in patients with chest pain if administered within 24 hours of being seen in the hosp...Nicotine metabolite may improve memory, protect against disease
...e day help scientists design new, safe therapeutic agents for hypothyroidism and other conditions that cause brain impairments. An estimated 5 million Americans have hypothyroidism, which produces a variety of symptoms, including such mental impairments as cloudy thinking, inability to concentrate, and mem...Elements of green tea prevent HIV from binding to human T cells
...or as an alternative therapy to current anti-viral agents now used. The concentrations of EGCG used to demonstrate these inhibitory effects in laboratory studies are many times over the blood concentration that could be achieved by normal green tea consumption. However, the current findings call for additi...Several commonly used pesticides are toxic to mitochondria in laboratory experiments
... safety of chronic exposure to these environmental agents and certainly warrants additional research." Last year Emory created a new Emory Collaborative Center for Parkinson's Disease Environmental Research through a grant of more than $6.5 million from the National Institute of Environmental Health Science...UCI Cancer Center selected by National Cancer Institute to test cancer prevention drugs
...ound of work on critical early phase trials of new agents and their biological effects." Overall, the UCI center currently receives more than $14 million in grants and contracts to conduct chemoprevention trials. Current studies include testing vaccines that can attack cervical cancer-causing viruses and...Memory-enhancing drugs for elderly may impair high-level brain function
...nd colleaguesfrom Yale University investigated how agents that increase PKA activityinfluence prefrontal cortical function in animals. The researchers observedthat, in contrast to hippocampal-dependent long-term memory, dynamic workingmemory in older animals is impaired by PKA stimulation and enhanced by PK...More than $34 Million in SPORE Grants
... of pancreatic cancer effect of numerous chemical agents that are available to inhibit NF-kappaB signaling pathways to further the understanding of important growth promoting signaling pathways in pancreatic cancer variation of DNA repair capability among patients with pancreatic cancer, and determine if ...New Hampshire lung disease research center funded
...work with state agencies to examine the effects of agents such as arsenic, radon, nickel and diesel exhaust. Funds will also support the recruitment of faculty, and the development of a new, state-of-the-art technical facility in proteomics -- the study of proteins -- that will enable scientists to study t...PTH and Alendronate: combining treatments shows no bone density advantage
... effect of PTH is somewhat diminished when the two agents are combined. Osteoporosis is a skeletal disorder marked by reduced bone strength that predisposes a person to an increased risk of fractures. This skeletal disorder is a major health risk for 28 million Americans. In the United States today, 10 mill...Gastric bypass surgery resolves or improves diabetes in most patients, reports Pittsburgh study
.... Schauer, "with 65 percent of them requiring oral agents and 27 percent of them requiring insulin as well."...ificant reduction in the use of oral anti-diabetic agents and 79 percent had a reduction in their use of insulin. "The impressive effect of bypass surgery on ...