Jefferson scientists find how HIV causes dementia
...rain atrophies. It's extremely unusual. Infectious agents don't do this, but HIV does." He notes that the effect "is clearly due to HIV." In patients taking the anti-retroviral HAART cocktail of drugs, which halts retroviral replication, fewer individuals develop dementia than those who do not take the drug...Discovery sheds light on how cancer cells grow and divide
...that helps cells form vesicles used to internalize agents from the cell's external environment. Through a series of laboratory manipulations of mammalian cells that included disrupting the centrosome, the research team was able to demonstrate that Dynamin-2 is a normal and necessary component of the centros...Personalized treatment goal of IU breast cancer study funded by $10 million DoD grant
... of Medicine. Individual responses to chemotherapy agents will be tabulated by pharmacogeneticist Brian Leyl...anisms that make tumors unique and the therapeutic agents they best respond to, producing individualized treatments. They will seek answers to questions such ...Researchers identify leukemia-linked pathway targeted by a new kinase inhibitor
...ALL. Their findings suggest additional therapeutic agents for treating this type of leukemia in humans. ALL is the type of leukemia that predominantly strikes children. Among ALL cases, 85% are of the B-ALL type. According to oncologist-turned-researcher Dr. Li, the preclinical studies suggest a specific pr...New light shed on atrial fibrillation after bypass surgery
...nown as atrial fibrillation, while those and other agents can offer protection. Since an estimated one in three bypass patients will suffer at least one episode of atrial fibrillation in the days and weeks following surgery, these and additional findings from a new international study have important clinica...Extended lymph node dissection fails to increase long-term survival among gastric cancer patients
...form a complete D1 lymphadenectomy, developing new agents for neoadjuvant and adjuvant clinical trials of gastric cancer and improving radiation techniques," said Nicholas J. Petrelli MD, editorial author and MBNA Medical Director of the Helen F Graham Cancer Center and Professor of Surgery at Thomas Jeffer...Molecular analyses of leukemia patients suggest strategies for better treatments
... and the effects of chemotherapy and environmental agents will also help develop optimal treatment, and may even provide important clues for the cause of leukemia. Together, these advances might one day permit physicians to cure all patients, regardless of the type of ALL they have, and might even lead to w...Novel MRI technique provides clear images of blood flow
...ls, non-invasively and without the use of contrast agents or radiation. They used a novel application of mag...on," Judd said. The problems presented by contrast agents can be potentially significant, Judd explained, since these agents can cause kidney damage, and many...Men with family history of prostate cancer accurately predict higher risk, UMHS study finds
...mately prevent prostate cancer since many of these agents have not been tested in formal clinical trials," says lead author Jennifer Beebe-Dimmer, M.P.H., Ph.D., a research fellow in the Department of Urology at the U-M Comprehensive Cancer Center. Further, Beebe-Dimmer notes, herbal supplements are not mon...Popular chewing gum eliminates bacteria that cause bad breath
...tistry. Wu, who searches for natural antibacterial agents from plant sources that suppress oral pathogens, h... over the short term, if it contains antimicrobial agents such as cinnamic aldehyde or other natural active compounds," Wu said. "The product doesn't just mas...Mayo Clinic researchers discover green tea component helps kill leukemia cells
...Dr. Kay: "We're continuing to look for therapeutic agents that are nontoxic to the patient but kill cancer cells, and this finding with EGCG is an excellent start. Understanding this mechanism and getting these positive early results gives us a lot to work with in terms of offering patients with this diseas...Jefferson scientists use zebrafish to show effects of ionizing, UV radiation differ in development
...how that while radiation and some chemotherapeutic agents damage DNA, there were different time periods in development in which the zebrafish were sensitive to either radiation or the drugs. "In general, drugs targeted for specific enzymes are used in combination with chemotherapy agents," he says. "We can ...Powerful stem cells harnessed to search for cancer metastasis
...ion selectively into tumors and produce anti-tumor agents only at the sites of these tumors and their metatasis." ...Making smart drugs that deliver the right kind of punch
...at all unless they have cancer-detecting targeting agents attached. "We can show that, with the targeting molecule attached, an uncharged dendrimer goes into cancer cells---and only cancer cells---and that's what we want," Mecke said. Early results of studies with mice show that the nanoparticle drugs do tr...Study: Carbon dioxide may find new use in producing medical implants
...elease medicines -- from antibiotics to anti-tumor agents - into the body. The high-pressure, high-temperatu...ncer, doctors may also need to dispense anti-tumor agents from the implant for a longer period, Tomasko explained. He's been working with David Powell, clini...UK industry is the loser from parallel trade in pharmaceuticals
...nd, the parallel traders view themselves as benign agents promoting competition in markets," he continues. "By contrast, pharmaceutical manufacturers view the activities of parallel traders as undermining pharmaceutical company profits and thus investment in research and development." An estimate of the imp...Older people lose out all round in breast cancer treatment and care
... and there was a need for special trials of single agents in older people to spare them this toxicity. Although one therapy (vinorelbine) had been shown to be really active and well tolerated in this age group, there were plenty of other current breast cancer therapies that still needed assessment in elder...New findings on nerve cell proteins show promise for reducing disability
...versity School of Medicine, to develop therapeutic agents based on the cellular stress response....Combination of toxin and poison may be novel treatment for leukemia
...ly. "Arsenic is similar to other chemotherapeutic agents in terms of its potential toxicity, and there's a trade-off in how much harm you do to normal cells versus cancer cells," says Wen-Chien Chou, M.D., Ph.D., a postdoctoral student at Johns Hopkins and first author of the research. "Yet, the synergist......eral studies on the efficacy of various anxiolytic agents in dentistry and also investigated efficacy and problems associated with different local anaesthetic agents. Dr. Haas is a regular attender and presenter at both IADR and AADR meetings and has previously served as President of the IADR's Pharmacology...