Other highlights in the January 7 issue of JNCI
...d that that risk is substantially higher for rare, aggressive forms of uterine tumors. In a Brief Communication,...cts, such as the increased risk of MMMTs, rare but aggressive tumors of unclear pathogenesis. Contact: NCI Press Office, 301-496-6641; ncipressofficers@mail...Depression, other psychiatric illnesses common following traumatic brain injury
...rcent also had anxiety, and 56.7 percent exhibited aggressive behavior. Major depression was also associated with worse social functioning at the six- and twelve-month follow-up, as well as reduced gray matter (a brain structure) volumes on brain scans. (Arch Gen Psychiatry. 2004;61:42-50. Available post-emb...Obesity linked to aggressive prostate cancer
...e men with prostate cancer are more likely to have aggressive tumors and to experience cancer recurrence after s...ggest that men may be able to modify their risk of aggressive prostate cancer by maintaining a healthy weight. The results of both studies will be reported Decem...Older prostate cancer patients may face age bias
...older men, particular those in their 70s, who have aggressive prostate cancer benefit significantly from surgery or radiation therapy. With appropriate treatment these patients can receive an extra year of life or more, with most having an improved quality of life as well, the earlier study showed. "This ne...EGFR status linked to poor survival in advanced breast cancer patients
... has been found in other cancers to produce a more aggressive disease, but this study is the first to firmly link expression of that protein to poor outcome in breast cancer, say the researchers, who presented their findings at the San Antonio Breast Cancer Symposium. "This is potentially important news in tha...Protein that predicts tamoxifen resistance is identified
...nce prior to treatment could help them devise more aggressive strategies from the outset. In years past, tamoxifen was the only option to help prevent breast cancers from recurring in women with estrogen-positive tumors, said Blackwell. But a percentage of women develop resistance to the drug. To better underst...Radiation treatment is an option for elderly prostate cancer patients
.... Thirty-three elderly men, most with advanced and aggressive forms of prostate cancer, were treated with external beam radiation therapy at the same radiation levels used to treat patients in their 50s and 60s. The elderly patients, whose five-year survival rate was 61.6 percent, experienced no unusual or pro...Altered cyclin E protein leads to genetic instability in breast cancer
...h the altered cyclin E protein may be offered more aggressive therapy from their initial diagnosis, Keyomarsi says. Using the cell line model system in this study, led by Said Akli, Ph.D., an instructor in Keyomarsi's laboratory, the investigators found that low molecular weight cyclin E has the ability to make...New MR technique may allow earlier diagnosis of MS
...lerosis (MS) can help physicians be more exact and aggressive in treating a disease that robs people of their youth and vitality, according to research presented today at the 89th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA). Using magnetic resonance (MR) spectrosco...Nitric oxide can prevent lung disease and death for premature infants
...ation of prematurity and RDS may be lethal despite aggressive treatment, including mechanical ventilation. Approximately 60,000 children are born each year in the United States weighing less than 1,500 grams (about 3.3 pounds). Many of those who survive suffer permanent lung damage, which can slow growth, inc...Study shows combining gene therapy and radiation holds promise
...re cancer-free after one year. The patients had an aggressive form of prostate cancer that, if treated with standard radiation therapy alone, would likely recur and possibly spread. While the results are encouraging, researchers say more research is needed and the novel treatment needs to be tested in a larger ...New test may diagnose heart disease risk better
...inflammatory HDL, the findings help to explain why aggressive statin treatment may benefit these patients. The next step, according to researchers, is to conduct larger studies that will validate their findings since the patient groups in these studies were relatively small. Other authors from the UCLA departme...Investigational drug brings new hope to kidney cancer patients
...rs had a cancerous kidney removed in 1981 but more aggressive cancer returned at multiple sites in 1995. An out-of-state specialist told him to "go home and get your affairs in order," but his family physician connected him with researchers at Chicago. His tumors initially responded to immune therapy with IL...Key feature of HeartMate II heart assist device developed at University of Pittsburgh
...programs in the United States. Known also for its aggressive work to enable patients on devices to be discharged to the home setting, UPMC was the first center to discharge a patient still on a device to await a human donor outside the hospital. Based on UPMC's experience, the U.S. Food and Drug Administration...Microneedles: Report describes progress in new technology for painless drug delivery
...hat are conducting clinical trials. "There is an aggressive movement toward bringing microneedles to the market," Prausnitz said. "We've shown that microneedles can serve as a hybrid drug delivery system, combining the advantages of conventional needles which deliver drugs easily with transdermal patches t...Age-related outcomes, immune response in patients with brain tumors linked to thymic cells
...emigrant T cells in 44 patients with GBM, the most aggressive of malignant brain tumors called gliomas. Twenty-four of these patients were newly diagnosed, while 18 had recurring disease. Seventeen of the patients were enrolled in immunotherapy vaccine trials. Although thymic output of T cells declines as part...Epstein-Barr virus contributes to Burkitt's lymphoma
... the system breaks down. "Burkitt's lymphoma is an aggressive B cell malignancy characterized by rapid cell proliferation that can be fatal within months if not treated immediately," says Sugden. The standard treatment is chemotherapy, which can destroy healthy as well as cancerous cells. The Wisconsin research...Women treated more aggressively for hypertension, yet results similar to men
...than their male counterparts and they receive more aggressive treatment for it, yet they obtain no better blood ...ent for men. Newby said that physicians need to be aggressive in treating hypertension, whether their patients are male or female. She added that awareness of the...News tips for Tuesday, Nov. 11, 2003
...ression and CVD risk: a role for testosterone? An aggressive personality may adversely affect risk factors for cardiovascular disease (CVD), and testosterone has been suspected of playing a part. In 933 healthy young men (average age 19), Polish scientists measured body mass index (BMI), cholesterol and testo...Newer formulation of heparin improves outcomes for suspected heart attack patients
...d non-ST-elevation myocardial infarction receiving aggressive anti-platelet therapies and early invasive procedures." The definitive answer should be available by spring of 2004, Singh said, when the results of the 10,000-patient SYNERGY randomized clinical trial are expected to be reported. That trial will dir...