Other highlights in the February 2 JNCI
...oside into an inactive metabolite. GATA1 is nearly always mutated in Down syndrome children with AMkL but not in non-Down syndrome AML patients. The authors conclude that this difference might explain why Down syndrome AMkL patients are more sensitive to the drug and respond better than non-Down syndrome AM...No magic pill for treating dementia symptoms
...ve treatments. They said non-drug therapies should always be considered first, and that some small studies have shown that music therapy, aromatherapy, pet therapy and caregiver education may be effective. "Larger, well-designed controlled trials of non-drug interventions are needed," said Sink, an assistan...Brain tumor treatment can vary greatly, according to new JAMA study
..., and I think that's one of the reasons they don't always have the best information," Norris said. "I've talked to patients right after surgery who've been told they have a year to live, so it's understandable why they get depressed, and I really think that can have an effect on their outcomes." Norris adde......d: "Although men over 25 and permanently sick were always found more likely to live alone, this was not so for women. There was no evidence to suggest that living alone for a long period results in permanent sickness being more likely. Nor did we find that those who stopped living alone suddenly ceased repo...Wisconsin scientists grow critical nerve cells
...ily differentiate in linear fashion, as scientists always believed. Rather, a series of complex overlapping changes may well be the developmental norm in higher vertebrates such as humans. "We cannot simply translate studies from animal to humans," says Zhang. The next step, Li says, will be to test if the ...Study shows that diabetes increases risk of blood poisoning
...rinary tract infection or bacteremia/sepsis should always seek medical care promptly, and doctors should keep a high level of suspicion for these infections if the patient has got diabetes," Dr. Thomsen added....US syphilis epidemics not driven by increases in unsafe sex say researchers
...here changes in the rate of new infections may not always be attributable to changes in behaviour or the environment....... originating from the Earth's crust. Swarm C will always fly higher, remaining at more than 500 kilometres altitude throughout the mission. Compared with its sisters, Swarm C will give simultaneous snapshots of the magnetic field over quite different regions of the Earth, and impressions of the same region...Clinical trial participants fare no better, no worse than other patients
...ity that in a general population patients will not always act according to doctors' instructions. In the new study, researchers led by Gunn Elisabeth Vist of the Norwegian Health Services Research Centre, systematically identified and reviewed 55 studies involving a total of more than 31,000 patients who we...Doctor report cards not always clear when comparing quality of care
...t the areas in which physicians are graded are not always clear-cut, according to researchers from the Johns Hopkins Bloomberg School of Public Health and School of Medicine. They examined the usefulness of quality indicators for asthma specialists; that is, individual aspects of patient care that can be us...Cancer vaccines: A two-pronged attack?
...ing about how cancer vaccines might work. "We have always thought that cancer vaccines could only be effective if massive numbers of vaccine-specific CTLs were produced. But it seems that, in about 10% of patients with metastatic melanoma, the vaccine might actually be reawakening different CTL populations ...Penn researchers add more evidence to demonstrate role of COX inhibitors in heart-disease risk
...lotting, causing heart attack or stroke." "We must always be cautious projecting the results of studies in mice to clinical outcomes in humans," says FitzGerald. "While low-dose aspirin works by switching off TxA2, a TxA2 blocker might act in subtle, but importantly different ways. However, in so far as it ...Women In Government report on eliminating cervical cancer
...iminate cervical cancer - a disease that is almost always preventable with the most-advanced screening technologies. The report titled, "A Call to Action: The "State" of Cervical Cancer in America," finds that none of the states are where they should be, based on cervical cancer screening rates, coverage of...Physician response to conflicts between faith and medicine
...eir patients, the authors suggest that this is not always possible. "Science tells patients what they can ... patients what they should do, and the latter is always a moral exercise." "Rather than striving for illusory neutrality," they conclude, "physicians should...Physicians' response to religion-related conflicts in medicine
...thors write: "Our findings suggest that physicians always navigate a balance between respect for patient autonomy (remaining open-minded and flexible) and concern for the patient's good (persuading the patient to adhere to recommendations)Rather than striving for illusory neutrality, physicians should pract...Mayo Clinic discovery on nature of rheumatoid arthritis lung disease may offer patients therapy
... who have seen our results say, 'This is what I've always believed.' But no one had proved it to them," says Carl Turesson, M.D., Ph.D., former Mayo Clinic research fellow now working at Malmo University Hospital in Sweden. Says Dr. Turesson, "Our work provides the evidence that was lacking, so from that st...Scientists uncover new mechanism for the amygdala in fear recognition
...xpressions. If the patient could be trained to always look at the eyes, the researchers suggest that her impaired fear recognition could be rescued permanently. The study may have implications for conditions such as autism, where patients also show abnormal fixation on facial features and have a disrupt...New findings on patient safety at children's hospitals
...statistically valid comparison of hospitals is not always possible. But the new analysis does show the need ...s or acute renal failure, for example, were almost always children with multiple severe conditions that together would be fatal," Sedman says. "This suggests ...Study shows long-term use of NSAIDs causes severe intestinal damage
...isible damage to their small intestine. "We have always known that NSAIDs can cause potentially deadly stomach complications, but the extent of the impact on the small intestine was largely unknown until now," said David Graham, MD, lead study author. "The introduction of video capsule endoscopy gave us ...Poor response to chemotherapy does not mean poor outcome for patients with rare breast cancer
...n order to shrink their tumors before surgery. "We always have thought that a poor response to chemotherapy always indicated a worse prognosis, but that is not true for every woman with breast cancer because this di...