Tag: "antagonist" at medical news
OHSU scientists test medication to treat involuntary weight loss
...ciple for Neurocrine's small molecule MC4 receptor antagonist
program in animal models relevant for cachexia," said Alan C Foster, Ph.D., Neurocrine Fellow and head of Neurocrine's neuroscience group. Neurocrine is a San Diego-based company that is developing medications related to weight regulation. "We hope...
New study finds kelp can reduce level of hormone related to breast cancer risk
...lity is that the kelp may be acting as an estrogen antagonist
by preventing estradiol from binding with its estrogen receptors," said Skibola. "Our next step is to try to isolate the active compound in kelp that is having this hormone-modulating effect." She noted that seaweed contains several complex compounds...
New research could help physicians tailor asthma therapy in children
...the goal when taking only the leukotriene receptor antagonist
55% of the children reached the goal when taking ...thma was improved only by the leukotriene receptor antagonist
were younger in age and had a shorter duration of the disease. Based on these findings, researchers...
Research guides medication choices for young Asthma patients
...fluticasone (Flovent) and the leukotriene receptor antagonist
montelukast (Singulair) separately for eight weeks each. The primary measure of response to medication was the amount of air a person can exhale in one second, known as FEV1. Improvement of 7.5% in FEV1 was considered a clinically significant and po...
Heart patients treated by non-cardiologists less likely to receive medications
...sus 32 percent by non-cardiologists) Aldosterone antagonist
(prescribed for 17 percent of patients upon discharge by a cardiologist versus 7 percent by non-cardiologists) The study also found that cardiologists are more likely to admit a CHF patient to the Intensive Care Unit and order diagnostic tests, incl...
FDA approves Enablex for treatment of overactive bladder
...le contraction. It is a potent muscarinic receptor antagonist
that helps reduce incontinence episodes, increases the amount of urine the bladder can hold, reduces the frequency of urination episodes, and decreases the pressure or urgency associated with the urge to urinate. "The M3 profile of Enablex is uniq...
Novartis announces collaboration with Bayer for EMSELEX
... EMSELEX, a new once-daily M3 selective receptive antagonist
(M3 SRA) recently received Marketing Authorization...EX EMSELEX is a once-daily M3 selective receptive antagonist
(M3 SRA) oral treatment that works by selectively inhibiting the M3 receptor, the primary mediator o...
Brain's nicotine receptors also target for anti-depressants
...ts with and without mecamylamine, a noncompetitive antagonist
(blocker) in nicotinic acetylcholine receptors (nAChRs). In a separate study using knockout mice that lack these receptors, they found that the function of the nicotine receptor in the brain was an essential component of the therapeutic action of ant...
Use of stomach acid-suppressive medications associated with increased risk of pneumonia
...ugs (such as proton pump inhibitors or H2-receptor antagonist
drugs). "The effectiveness of acid-suppressive drugs in the treatment of upper gastrointestinal tract symptoms is excellent. Acid-suppressive drugs nevertheless seem to have some significant drawbacks," write the authors. "Persons using acid-suppr...
Advances in understanding brain circuits responsible for tics in Tourette's shed light on disorder
...peak in early adolescence." Knowing that dopamine antagonist
drugs reduce the tics associated with Tourette's and that selective serotonin reuptake inhibitors reduce the symptoms of obsession and compulsions, Roger Albin, MD, and colleagues at the University of Michigan department of neurology investigated the...
Topiramate: a potential new medication for treating alcoholism
...or the treatment of alcohol dependence: the opiate antagonist
naltrexone and the alcohol-aversive agent disulfiram. A third medication called acamprosate (calcium acetyl homotaurinate), used in Europe and elsewhere to prevent relapse in alcoholics, is currently under review for use by the U.S. Food and Drug Ad...
Darifenacin substantially improves quality of life for people with overactive bladder symptoms
...adder). Darifenacin is a new M3 selective receptor antagonist
in development for OAB, which is proven to reduce the number of weekly incontinence episodes by up to 77%.6 The main treatment-related effects were noted as being constipation and dry mouth that resulted in low discontinuation rates. Regulatory appli...
New data demonstrates that Benicar(R) and Benicar HCT (TM) achieve JNC 7 blood pressure goals
...; Namenda, an N-methyl D-aspartate (NMDA) receptor antagonist
indicated for the treatment of moderate to severe Alzheimer's disease; Tiazac, a once-daily diltiazem, indicated for the treatment of angina and hypertension; Benicar, an angiotensin receptor blocker indicated for the treatment of hypertension; Benic...
New darifenacin data released at the American Urological Association (AUA)
...arifenacin hydrobromide), an M3 selective receptor antagonist
(M3 SRA) being developed for the treatment of over...artis in 2003, Enablex is an M3 selective receptor antagonist
(M3 SRA), which works by selectively blocking the M3 receptor, a primary mediator of detrusor muscle...
ERI patents treatments for insulin resistance in diabetes accompanying obesity
..., is for treatment of diabetes by administering an antagonist
of MSH. The patent covers the use of a whole class of MSH antagonists, chemicals that either remove the hormone from the system or which block the action of MSH in the bloodstream. "Because type II diabetes is essentially an insensitivity to insulin ...
Advances in prevention and treatment research hold promise for 'pipeline'
...Area Oncology tested the new progesterone receptor antagonist
in tumor cell models and observed strong antiproliferative activity. The progesterone receptor antagonist
also prophylactically prevented the development of breast tumors following a chemical challenge desi...
Blocking selected neurotransmitter activity may decrease alcohol consumption
...BL/6 to examine the effects of the NPY-Y5 receptor antagonist
L-152,804 on the onset and maintenance of alcohol ...ting alcoholism. Furthermore, since this receptor antagonist
is able to delay the onset of alcohol-drinking behaviors in alcohol-preferring mice, it also has pot...
Beta-blocker or calcium antagonist-based therapies equally effective in treating hypertension
...ertensive patients with CAD treated with a calcium antagonist
strategy (CAS; verapamil sustained release [SR]) or a beta-blocker, non-calcium antagonist
strategy (NCAS; atenolol). Because most hypertensive patients require more than 1 agent to adequatel...
PRAECIS PHARMACEUTICALS INC receives FDA approval for Plenaxis
...is the first gonadotropin releasing hormone (GnRH) antagonist
available as a depot formulation. Plenaxis TM is indicated for the palliative treatment of men with advanced symptomatic prostate cancer, in whom LHRH agonist therapy is not appropriate and who refuse surgical castration, and have one or more of th...
Darifenacin increases 'warning time' for OAB sufferers
...eatment option and the first M3 selective receptor antagonist
(M3 SRA) currently awaiting regulatory approval in the US and Europe. As presented by Linda Cardozo, Professor in Urogynaecology at Kings College Hospital London, urgency was reported as being one of the most distressing symptoms for patients with ov...
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