Houston meeting kicks off collaboration to advance cancer research
...additional opportunities to identify promising new anticancer agents for clinical development and to investigate new methods for diagnosing and treating cancer. Imperial hopes to expand its range of research programs and further contribute to the improvement of healthcare globally. According to John Mendelsohn,...Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
...o predict the molecular targets of a potential new anticancer compound, PTSB, shown in CMLD studies to inhibit growth in the test organism (baker's yeast) as well as in human small lung carcinoma cells. Their algorithm predicted, and subsequent experiments verified, that PTSB acted on thioredoxin and thioredoxi...Chemicals in apples could reduce the risk of breast cancer, Cornell study in rats suggests
...t are responsible for their potent antioxidant and anticancer activities," Liu says. "Our findings suggest that consumers may gain more significant health benefits by eating more fruits and vegetables and whole grain foods than in consuming expensive dietary supplements, which do not contain the same array of ...Mayo Clinic researchers create 'obedient virus'; First step to use measles virus against cancer
... used internationally for vaccinations has natural anticancer activity. "But we had a concern that the measles virus may be a little too promiscuous in its ability to infect both cancer cells and non-cancer cells, so we wanted to develop a method whereby we could retarget the virus to infect cancer cells only,"...How platelets help cancer invade other tissues
...iculty in translating these results into effective anticancer therapies is the need to consider the important role that platelets play in arresting bleeding, for example in the event of a nosebleed or following injury or surgery. In an accompanying commentary, Gaorav Gupta and Joan Massagu from Memorial Sloan-K...Celecoxib shows surprising activity against estrogen receptors
... estrogen - could help explain the drug's observed anticancer properties, says the study's lead author, Banu Arun, M.D., associate professor in the Department of Breast Medical Oncology. "Since estrogen receptor expression is a marker of proliferation, this finding confirms celecoxib's antiproliferative proper...Tumor size alone not always best for gauging treatment response
... Haesun Choi, MD, lead author of the study. "Since anticancer therapy is focusing more toward targeting a particular molecule or receptors at a cellular level, we should look into evaluating biologic changes, too, rather than just anatomic changes," she said. Current guidelines require monitoring only tumor si...Women taking breast enhancement pills swallow empty promises
...l pills. Black cohosh may increase the toxicity of anticancer drugs. Fenugreek contains elements that can interfere with medications designed to stop blood clotting and regulate diabetes. In addition, the primary ingredients of don quai, which have been used in China for more than 2,000 years to treat and relie...Study finds HER2-positive breast cancer invades organs due to fatal chemical attraction
...tion that an agent that can block CXCR4 could have anticancer potential," says Hung. Efforts are now under way to develop such a drug to treat cancer, he adds. The work was funded by grants from the National Institutes of Health, the National Breast Cancer Research Foundation and the U.S. Army Breast Cancer Res...St. Jude scientist to lead NCI Pediatric Preclinical Testing Program
...hildhood cancer types and to a broader spectrum of anticancer agents. The PPTP will test anticancer agents against panels of preclinical models of the most common childhood cancers. The in vivo testin...Engineered stem cells can home in on tumors and deliver drug payload in mice
...Cancer Center have perfected a delivery system for anticancer treatment that zeroes in on a tumor and becomes pa...oming into tumors and are capable of delivering an anticancer payload," he says. "Now we can work to test a number of different therapeutic payloads to see which ...New compounds show promise in fighting malaria and cancer
...f the trioxane compounds against two gold standard anticancer drugs, Gemzar and Adriamycin. They found that whil...r their antimalarial potential, but also for their anticancer potential," Posner said. ...Drug to fight virus in transplant patients moves forward in trials
...had been primarily the design and synthesis of new anticancer drugs. Townsend agreed to peruse his library of anticancer compounds so Drach could test them for potential effectiveness against CMV. Chemotherapy drugs work ...Global study shows new breast cancer drug extends patients' overall survival
...nced breast cancer but were already exposed to the anticancer class of drugs known as anthracyclines when their breast cancer was first diagnosed in an early stage. Participating in the study were 529 patients randomized at 98 sites in 19 countries. The study compared gemcitabine plus paclitaxel to pacl...Herbal supplements' testing topic of discussion at chemistry meeting March 30
...benefits, including antioxidant,anti-inflammatory, anticancer and heart-protective properties. He willdiscuss studies showing such benefits of these bioactive compounds fromherbal products. ( AGFD 106 , Tuesday, March 30, 3:40 p.m.) Quality issues about plant products in the United States: Mingfu Wang, Depa...Cancer cells can compress blood vessels, block entry of drugs
...e more information about improving the delivery of anticancer drugs to tumor cells. "We've known for several ye...matrix, composed of connective tissues which block anticancer drugs from reaching tumor cells. The new imaging tool two-photon fluorescence correlation microsco...Targeting cell fusion as possible way to repair organs, deliver cancer vaccines
...to exploit this tendency and use it as a basis for anticancer treatment. The ability to target fusion partners is important. If the wrong cells fuse, then healthy cells -- instead of cancer -- can be killed. "Our biofusion research brings a new level of control to the system so the right fusion matches are ...Cancer vaccine using low affinity epitopes proves successful in mice
...sed in more than 80% of human tumors as potential anticancer vaccines. In the February 2 issue of the Journal of Clinical Investigation they report that epitopes with a low affinity for HLA class I molecules, molecules which bind and present antigens to T cells for killing could be modified to generate an imm...GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
... growth and replication, are being investigated as anticancer drugs. "By targeting a different stage of RT activity, Ribonuclease H inhibitors also may be effective in treating HIV that has developed resistance to conventional RT inhibitors," Dr. Zhang said. A New Strategy to Inhibit Tat Tat is a regulatory pr......mbination of ZD6126 with another AstraZeneca novel anticancer agent in development known as ZD6474, an anti-angiogenesis agent. Anti-angiogenesis agents being developed by AstraZeneca are designed to block the vascular endothelial growth factor (VEGF) signaling pathway. This pathway is a critical step in angi...