International breast cancer prevention study launches in the United States and Canada
...American clinical trial to evaluate the role of an aromatase inhibitor in the prevention of breast cancer. C...ease. Exemestane part of a class of drugs called aromatase inhibitors suppresses estrogen production, a key component in the development of some types of brea...Poor response to chemotherapy does not mean poor outcome for patients with rare breast cancer
...rognosis group). Use of hormonal therapies such as aromatase inhibitors "may represent an interesting approach to treating invasive lobular carcinoma," and that use of systemic chemotherapy might be limited to women with inoperable invasive lobular carcinoma tumors, he says. "In the end, our study indicates th...Re-analysis of large trials shows greatest benefit of chemotherapy in ER-negative tumors
...positive tumors, with development of SERMs and now aromatase inhibitors, but ER-negative patients have been left in the lurch," Berry says. "Not so. This analysis demonstrates that chemotherapy use has more than doubled survival rates in women with ER-negative tumors."...Aromatase inhibitors should be first-line treatment for certain type of breast cancer
...could instead benefit from a class of drugs called aromatase inhibitors, conclude authors of a fast-track study...er, UK) comments: "Results from studies evaluating aromatase inhibitors after 23 years or 5 years of adjuvant tamoxifen, compared with continuing tamoxifen, sugg...Updated adjuvant data presented at SABCS show 30 percent reduction in recurrence
...al therapy that belongs to a class of drugs called aromatase inhibitors which work by blocking the production o...ical Oncology (ASCO) recommendations on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone-receptor-positive breast cancer...Iressa news backgrounder: Testing of smart drug expands at M. D. Anderson Cancer Center
...m benefit, says Cristofanilli. Armidex is an aromatase inhibitor that works to stop estrogen production, reducing the fuel that feeds estrogen-positive breast cancer. Arimidex has been approved for use in early breast cancer and as a first line treatment option for advanced or locally advanced postmenopa...Leading cancer doctor calls for new guidelines to control early reporting from clinical trials
...th European Breast Cancer. Three recent trials* of aromatase inhibitors (AIs) as adjuvant treatments for breast...nnouncement last week that exemestane, a steroidal aromatase inhibitor (SAI), was more effective than tamoxifen in preventing cancer returning in women whose bre...Doctor attacks South African government for failing women while spending billions on arms deals
...gnated at the level of 1990. Newer drugs, notably aromatase inhibitors, taxanes, navelbine and trastuzumab are not available. Radiation equipment is outdated and breakdowns are frequent. Waiting times for radiation in breast conservation are four to six months," he said. "Furthermore, in an environment with...Exemestane beats tamoxifen in first phase III head to head trial in advanced breast cancer
...female hormones to grow. Exemestane is a steroidal aromatase inhibitor (SAI); it permanently inactivates aromat... to what has been seen in studies of non-steroidal aromatase inhibitors (NSAIs). "We don't know yet whether that will translate in the long term into greater car...Aromatase inhibitors: A promising new treatment for endometriosis
Letrozole (Femara), an aromatase inhibitor currently used to prevent breast cancer ...lity . "This study demonstrates the potential of aromatase inhibitors to significantly and rapidly reduce disease severity and pain, offering women a new and m......g-term benefit, says Cristofanilli. Armidex is an aromatase inhibitor that works to stop estrogen production, reducing the fuel that feeds estrogen-positive breast cancer. Arimidex has been approved for use in early breast cancer and as a first line treatment option for advanced or locally advanced postmenopa...New treatment improves long-term outlook for breast cancer survivors
... works by limiting the ability of an enzyme called aromatase to produce estrogen, a major growth stimulant in many breast cancers. Mayo Clinic medical oncologist James Ingle, M.D., says, "Based on our findings, all post-menopausal women with hormone-receptor positive tumours completing about five years of tam...New treatment significantly improves long-term outlook for breast cancer survivors
... works by limiting the ability of an enzyme called aromatase to produce estrogen, a major growth stimulant in many breast cancers. Mayo Clinic medical oncologist James Ingle, M.D., says, "Based on our findings, all post-menopausal women with hormone-receptor positive tumors completing about five years of tamo...New evidence eases some concerns about bone fracture risk with breast cancer drug
...r treatment, the ATAC[1] trial, which compared the aromatase inhibitor anastrozole with breast cancer's current gold standard hormone treatment tamoxifen, and with both treatments combined. The trial, involving more than 9,000 post menopausal women in 21 countries, last year revealed that over a median follow-...New test can identify patients who may suffer serious late toxicity from radiotherapy
...e Phase III study will compare tamoxifen versus an aromatase inhibitor in breast cancer in terms of fibrosis, using our test as a stratification factor."...Exemestane shows high tumor response rate in first-line treatment of advanced breast cancer
... It is the first and only oral drug in a class of aromatase inactivators. Its unique mechanism of action work...ectively targeting and irreversibly binding to the aromatase enzyme. This enzyme is required to produce estrogen in the breast. Since some breast cancer cells ...Initial Avon/NCI breast cancer research grants awarded in 'Progress for Patients' awards program
...al research in breast cancer, including the use of aromatase inhibitors as a prevention tool, new methods of radioimmunotherapy for women with metastatic disease, as well as other areas of research. The Progress for Patients program was launched in October 2001 when the NCI received a $20 million pledge from t...Breakthrough in hormonal breast cancer therapy
...vents The ATAC results show that anastrozole, an aromatase inhibitor (AI), is more effective in reducing the risk of cancer recurring in the same breast, the opposite breast, or elsewhere in the body when compared to tamoxifen. This is the first time an AI has been proved to be superior to tamoxifen in earl...Early promise of alternative hormone treatment for breast cancer
...itial vanguard of several trials that will examine aromatase inhibitors in breast cancer, including anastrozole...accelerated bone loss, questions about whether all aromatase inhibitors cause this effect, and of how this might be prevented with the concurrent use of bisphosp...Hormone therapy for breast cancer - the treatments of the future
...n enzyme called aromatase. A class of drugs called aromatase inhibitors is effective in older women. "The latest, third generation aromatase inhibitors, anastrazole (Arimidex), letrozole (Femara) and exemestane (Aromasin), can achieve almost...