Scientists Report Cancer Fighting Drug As Possible Treatment For Multiple Sclerosis
...substances, called cytokines,playing a role in the autoimmune process damaging the CNS in MS: tumor necrosisfactor-a (TNF-a), Fas-ligand (FasL) and interleukin-4 (IL-4). TNF-a and FasL aretoxic to CNS myelin and to the myelin-producing brain cells calledoligodendrocytes, which are a prime target of the immune a...Lupus Foundation Of America Awards Summer Internship To Student Working At Wistar Institute
...where her research focuses on antigens targeted in autoimmune diseases such aslupus erythematosus. Following her graduation, Ms. Seo hopes to combine clinical practicewith research in immunology. The Wistar Institute, established in 1892, was the first independentmedical research facility in th...DNA-Based Cancer Vaccine Shows Promise To Successfully Treat Melanoma In Mice
...tcome. "Our goal was to induce a very controlled autoimmune response that would lead toprotection against tumor spreading," said Dr. Houghton, a pioneer in the fieldof melanoma research and cancer vaccines. "The human DNA induced an autoimmuneresponse that prevented the tumor from spreading, and as a side ef...Study Ties Cerebral Palsy To Inflammation And Blood-Clotting Abnormalities
...e due to chronic or reactivatedconditions, such as autoimmune disorders or chronic infections in the womb,rather than acute infections just before or after birth, which normally cause arapid rise and fall of inflammatory cytokines, says Dr. Nelson. It is not yet clear how elevated levels of cytokines might incr...UCSF Study Finds DHEA Benefits Cardiovascular Function
... brain diseases,including Alzheimer's disease, and autoimmune diseases, such as lupus. Some ofthe lingering questions also include why only humans and primates manufacturethe hormone and why it diminishes sharply with age. This study, part of UCSF's continuing research of DHEA's effects oncardiovascula......t sets of cytokines is disrupted, such as numerous autoimmune diseases like multiple sclerosis and juvenile diabetes....USC Researcher Lights Up The Immune System To Help Heart Transplant Recipients
...t this therapy could be used to treat a variety of autoimmune diseases, including inflammatory bowel disease and ulcerative colitis. It may also have a dramatic impact on the treatment of potentially lethal complications of bone marrow transplantation, such as graft vs. host disease, as well as in o......ain and kidney problems. Treatment for severe autoimmune diseases using high-dose cyclophosphamidefollowedb...ze and attack foreign bodies." In people with autoimmune disorders, the immune system attacks its owntissues andorgans and must be re-taught to differentiate......rtunitiesto intervene directly in inflammatory and autoimmune disease processes, thusoffering unique alternatives to current symptomatic treatments. Dynavax has developed a strong patent portfolio including allowed patents andpatent applications. The company has key proprietary positions on ISS sequencesthat ar...IOM Report Offers New Look At U.S. Vaccine Priorities
... vaccines for chronic conditions such ascancer and autoimmune diseases. Second, it evaluates both short-term (10 years)and long-term (20 years) priorities. As requested, the committee limited their analysis to no more than 30 vaccinesthat would be feasible to license within 20 years. The quantitative model th...... an active and/or chronic infection,malignancy and autoimmune disease are unknown. Patients with a seriousinfection, including sepsis, or who are allergic to ENBREL or any of itscomponents should not take ENBREL. If patients develop an infection while onENBREL, they should talk with their doctor immediately a...ENBREL (Etanercept) Receives FDA Approval For Treatment Of Juvenile Rheumatoid Arthritis
...market ENBREL in North America. JRA is an autoimmune system disease that strikes children before agesixteen and can cause painful joint swelling, deformity, stunted growth andincreased mortality. According to the Arthritis Foundation, JRA affectsapproximately 50,000 children in the United States. Th...Weizmann Institute scientists develop a potential future treatment for myasthenia gravis
...en University in Tel Aviv. Myasthenia gravis is an autoimmune disease in which the body's immune systemmistakenly attacks the receptors in muscles that pick up acetylcholine, achemical messenger that transmits signals from nerves to muscles. As theseacetylcholine receptors are blocked by antibodies and progress...Researchers discover treatment that delays onset of insulin-dependent diabetes
...symptoms in mice. Insulin-dependent diabetes is an autoimmune disease in which the body mistakenlyrecognizes insulin-producing cells as being foreign. The immune system in turntries to destroy the cells. When this occurs, the body stops producing insulin,and the diabetic patient must receive an injection of i......evelopment or course ofinfections, malignancy, and autoimmune disease are unknown. The most frequentadverse events in adult clinical trials were injection site reactions (ISR) (37percent), infections (35 percent), and headache (17 percent). Malignancies wererare (<1 percent). Only the rate of ISR was hig...National Jewish researchers first to identify component in thymus that positively selects T cells
...ment is necessary to comprehend the development of autoimmune diseaseslike cancer. In the thymus, the major histocompatability complex molecule (MHC) acts as a'filter' for new T cells. Although scientists have long known that the thymuswas the screening location for T cells, Dr. Staerz and a team of researcher...Stress may increase susceptibility to infectious disease
...unesystem, such as AIDS and autoimmune diseases. "The evidence so far suggests that while the immunechanges associated with psychological stress are generallysmall, they look like they're important enough to have biolog...Combination immune therapy kills melanoma in mice
...attacking its own body, otherwise we'd all develop autoimmune diseases,"said Allison. "CTLA-4 is one of the regulatory molecules involved in thisprocess." Other autoimmune diseases include rheumatoid arthritis, lupus andmultiple sclerosis. Allison explained that the flip......ormed on a nine-year-old girl inhopes of curing an autoimmune disease that has made her life unbearable. Mollie ...rs for otherchildren who suffer from JRA and other autoimmune diseases." Mollie suffers from an extreme case of systemic onset juvenilerheumatoid arthriti......tal, it is possible that somepeople with resistant autoimmune disease may ultimately benefit from thisapproach. * * * The Diagnosis of Suffering Physicians may be diagnosing illness but may fail to diagnose the suffering,says a noted ethicist (Perspective, p. 531). The alleviation of suffering iscrucia...