A new protective protein against Parkinson's disease
...neous dominant mutation has a protective effect on axons in an mouse model of Parkinson's disease. Parkinso...egeneration), is associated with the protection of axons from a process known as peripheral nerve Wallerian degeneration -- that is, degeneration of axons fo...MGH study details brain changes in autism, language disorder
...elination, in which portions of nerve cells called axons are covered with a material called myelin. The rep...s showing the greatest volume increase is when the axons in those areas myelinate, a key step in maturation that allows nerve impulses to be transmitted prop...Study finds nerve damage can affect opposite side of body
...ated near the spinal cord, and nerve fibers called axons extend into the limbs. When axons are severed, downstream nerve endings are cut off from the cell body and die. Reports of opposite-...Study: New neurons can get out of spinal cord
...ant professor of neurology. "It's significant that axons from these motor neurons make it outside of the co...ous." In these first animal studies, however, the axons of these new neurons didn't poke through the spinal cord and out to muscle targets. Kerr reasoned th...Preliminary results are promising in Alzheimer's gene therapy trial
...o near-normal size and quantity, and also restored axons connecting the brain cells, essential for communication between cells. With the last human subject now more than a year beyond surgery, no adverse effects from the NGF-producing implants have been detected in the subjects, an indication that the biol...Researchers invent way to determine optimal conditions for spinal cord nerve regen in lab animals
... does this by providing channels through which the axons (nerve endings) grow. The new measurement method shows that the scaffolding not only supports axon regeneration when seeded with cells that stimulate regrowth, but that it can quantify axon growth under different experimental conditions. "Knowing wh...New technology shows axons are extremely sensitive to directional cues
...er and troubleshooting manual, nerve fibers called axons must follow molecular cues to find the right targe...nt with which one could measure the sensitivity of axons to gradients, and how that sensitivity can impact and guide the development of connections in the br...Promise of stem cells amplified
... scar-forming cells may block the re-insulation of axons by the oligodendrocytes. "Older, scarred spinal cord injuries pose another hurdle that we have yet to conquer," he says. "Future studies may find a way around this barrier." The broader accomplishment of this work, says Keirstead, is the generation ...New technologies shed light on schizophrenia
... the number, thickness, density and arrangement of axons (the hair-like extensions of neurons, which send m... patients had smaller UF and CB. These bunches of axons are wrapped in myelin sheaths and bundled like electrical wire. The UF connects different parts of ...Several new techniques show promise for spinal cord repair
... that OECs assist the normal regeneration of these axons and guide them into the brain where they make new functional connections. Because axons lose myelin after a trauma such as spinal cord injury, scientists have explored using OECs as a poss...Nerve navigation findings prompt new direction for spinal cord research
...ystem development. She explains that for axons to journey across the spinal cord, floor plate cel... or the proper connection. Developing axons can sense and navigate their environment but how the two functions work together to result in the ax...Stem cell therapy for spinal injury
...d of glial cell that encourages the growth of pain axons in the spinal cord by secreting substances that stimulate neuronal development. The researchers found that the presence of neurogenin-2, a "transcription factor" that regulates the activity of other genes during the stem cell maturing process, inhibi...News tips from the Journal of Neuroscience
...yelin-based inhibitory factors. On the other hand, axons in the PNS are much more resilient. This week, Qiu et al. provide evidence for Janus kinase (JAK)signal transducer and activator of transcription (STAT) signaling downstream of the cytokines. The JAK2STAT3 pathway appears to be growth-promoting after......onception. These cells may serve a role in guiding axons or transverse neuronal migration akin to the "pioneer" neurons in invertebrates or the transient early neurons in several mammalian species. 2. Goals and Habits in the Overtrained Rat Alexis Faure, Ulrike Haberland,Franoise Cond, and Nicole El Mass...