Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
... adrenergic receptors on the fat cell surface.This binding transmits a message inside the cell, telling it to burn calories and releaseheat energy. As the process continues, energy burned by brown fat exerts its metabolic effectson white fat -- in essence "burning" stored white fat. In demonstrating noradre...What Makes Tics Tick? Clues Found In Tourette Twins' Caudates
...he NIMH Clinical Brain Disorders Branch found that binding to D2 dopamine receptors in the caudate nucleus wa...ee to which the twins differed in this caudate D-2 binding predicted almost absolutely their differences in tic severity," said Weinberger. "This also likely ...Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
... the way they bindwith other molecules. Such binding reactions, which occur constantly in watery soluti...und the protein'sbinding site to make room for the binding partner, said Eric Toone, a Dukeassociate professor of chemistry. Removing this water provides...Mother's Milk: Nutrition And Nurture For Infants -- And The Best Defense Against Disease
...onjugates, in particular, may inhibit infection by binding topathogens at the molecular sites that they would...cterial role islactoferrin, a protein that acts by binding iron in different situations. Insome circumstances, lactoferrin is also able to act as a cytokine. ...Common Drug-Capsule Coating Not As Inert As Previously Thought
...ns withthe proteins that will result in the latter binding to the polymer surface. "Not only did the polymer switch from a protein-resistant stateto a protein-attractive state, we found the presence of the protein appearedto induce a change in the polymer configuration," Leckband said. "Thissuggests there ...Affordable, Hand-Held Biosensor For Diagnostics
...ications. Another biosensor provedsensitive to the binding of certain antibodies, manufactured by the body'si...fullyunderstood, the scientists speculate that the binding of molecules to thesurface significantly alters the refractive index of the silicon matrix itself,re...Penn Researchers Create Drug To Help Target Attack On Cancerous Tumors
...vans. "We'll be able to non-invasively examine the binding of EF5 for other diseases in which hypoxia occurs, such as heart attacks and strokes, in addition to the use in cancer."...Chemist Turns To Self-Assembly To Create New Drugs
...tle molecules to it, andsee which ones are best at binding the receptor." The work is the latest develop...oring if the resulting compound doesn't succeed in binding thetarget molecule. This gives them the chance to try their luck ina new alliance. With current meth...Snipping Inflammation In The Bud; New Agents May Provide Relief
...selectin helps mediate an inflammatory response by binding to thecarbohydrate groups attached to protein molecules on the surface of an opposingcell," said Kiessling. "The many copies of L-selectin on the white blood cellsurface bind with the many copies of the L-selectin-binding protein on the bloodvessel, ...Tighter Chemical Binding = Better Meds
New Haven, Conn. -- Many medications work by binding tightly to aprotein and disrupting its normal func...ls with the help of computers. "Stronger chemical binding generally leads to a more effectivedrug that can be given in lower dosages, thus reducing unwantedsi...Is Ritalin As Effective--And As Harmless--As It Could Be?
...t's more, they say,because of its high-specificity binding of dopamine receptors, d-threo taggedwith carbon-11 might prove useful as a PET radiotracer to probe the neuronalloss that occurs in normal aging and in neurodegenerative conditions such asParkinson's disease. Paper ORGN 3 will be presented by Y. S. ...New Drug Prevents Breast Cancer In Postmenopausal Women, UCSF Researchers Report
...ffects on her breasts and uterus. Estrogen acts by binding to structures called receptors in various target tissuecells, which then stimulate different responses. The hormone can cause tissuegrowth in a woman's breasts and uterine lining, and over time, may increase herrisk of breast or endometrial cancer. ......s. The views ofthe advisory working group are not binding but are expected to be given a gooddeal of weight. Research on EMF-related issues is likely to continue at some level. Thefuture focus of the research may depend on the views expressed by the workinggroup and the Director's report to Congres...Crystal Structure Of gp120 Reveals HIV In Action
...- a viral surface glycoproteincaught in the act of binding a CD4 T cell receptor -- graces the covers of both...r. "From years of work on mutagenesis and antibody binding analyses, we had a murky idea of what the protein lookedlike and knew the parts that could be delete...Drug Prevents Hearing Loss Caused By Brain Tumor Therapy
...s open. STS apparently protects hearing by binding to the platinum incarboplatin before it has a chance to harm the inner ears, Neuwelt said. "The take-home message is that sodium thiosulfate is the first drugshown to prevent chemotherapy-induced hearing loss. These resultswith STS may prove ...Neurotransmission Machinery Visualized For The First Time
...s shows a neurotransmittercrossing the synapse and binding to receptors on the surface of a neighboringneuron...ons, could alsobe important for fusion and for the binding of regulatory factors affectingneurotransmission, say the researchers. "The complex may act sort of...Cure Rate Soars For Some AML Patients Receiving High-Dose Drug
...led that 78 percent of patients with “core binding factor” AML who received the drug cytarabine ...osomes 8 and 21 were assigned to the “core binding factor” (CBF) group; those with no visible chromosome damage were assigned to the “n......wly solved structure clarifies how mutations alter binding to the DNA nucleotide or to the nucleotide analog ...mutations prevent the nucleotide analog drugs from binding to the enzyme. These mutations do not prevent normal nucleotides from binding, however, which allows...Substance Discovered That Induces Hair Follicle Formation In The Mature Skin Cells Of Mice
...ns. In adult epithelial cells, it participates in binding neighboring cells together to facilitate cell-cell communication. But during embryogenesis, beta-catenin appears to have another role: it reacts with a molecule called LEF-1, which is expressed only in cells that will eventually become hair follicle...... liver into a chemical thatinactivates P450 2E1 by binding to it and preventing its catalytic activity. "Byturning off this enzyme we can prevent the molecular pathway leading tohalothane toxification, and by extrapolation, possibly prevent halothanehepatitis," he said. Kharasch has identified the...