Shark-Liver Substance May Slow Growth Of Brain Tumors
...t week reported that squalamine appears to work by blocking a protein in endothelial cell membranes that is activated by VEGF and other growth factors. The studies' other authors were Darin S. Epstein, B.A., and Eric P. Sinos, M.D., of Hopkins and Delwood Collins, Ph.D., and Jon Williams, Ph.D., of Magainin....Discovery Hints At Multitude Of New Targets For Drugs
...r,switching it on. And others were "antagonists," blocking itsaction. However, surprisingly, they discovered a new class of compounds that behaveddifferently from either of the first two classes. The compounds functionedas agonists in some cellular contexts, but as antagonists in others. D...ACTG 315 Preliminary Results: Drug Cocktail Restores Partial Immune Function
...334, cyclosporin plusantiviral therapies, aimed at blocking the immune activation thatmay potentiate viral replication. NIAID is a component of the NationalInstitutes of Health (NIH). NIAID conducts and supports researchto prevent, diagnose and treat illnesses such as HIV disease andother sexually transmitt...Laser Shown Effective In Patients Who Are Not Candidates For Bypass Surgery Or Angioplasty
...iesfeeding the heart and inflated, clearing plaque blocking the artery. During a laser procedure, surgeons gain access to the heart througha 6- to 8-inch incision in the patient's side. Once the surface of theheart is exposed, the doctors fire short pulses of laser energy into theleft ventricle -- the ...Routine Dental X-ray May Be A Valuable Tool In Stroke Prevention
...y be confined to the arterial walls and may not be blocking the vessel," she said. "But when we find it, patients should be referred to their physician immediately for a full work-up." Individuals should not consider it strange that their dentist would be the first to warn them about stroke, Carter said...Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
...to the signaling that takes place withincells. And blocking these binding events using synthetic molecules is thebasis of action of almost all pharmaceutical compounds, Toone said. Chemical reactions in the body typically unfold when smaller molecules,called "ligands" form temporary combinations, called...Transcranial Magnetic Stimulation Enhances Short-Term Brain Plasticity
... elbow to shut offthe blood supply to the forearm, blocking nerve signals to the brain andtemporarily mimicking what occurs after amputation. The loss of normal signalscaused the brain to reorganize. When the researchers applied TMS to the plasticcortex, or the part of the brain that was undergoing reorgani...Bi-Monthly Boosts Of Aspirin Benefit Heart
...Aspirin helps prevent heart attacks and strokes by blocking thegeneration of thromboxane, a chemical produced ... thromboxane synthesis," says Marcus."Insufficient blocking of this thrombosis-promoting property of red blood cellscan lead to additional thrombotic complicati...Added Benefit Found For Aspirin Use In Patients With Vessel Disease
...t of aspirin on vascular function can berelated to blocking the negative effects of these substances and restoringnormal function of the vessel. Aspirin may now provide another way for physicians to fight back againstheart disease, according to the researchers, who are based at the NationalHeart, Lung......aloxifene is an antiestrogen, a drug that works by blocking theestrogen receptors in the breast, thereby preventing the hormone estrogen fromcontributing to the growth of cancer. Jordan and other breast cancer researchersbelieve that the estrogenic properties of drugs such as raloxifene may also betargeted to...Drug's Effect On Chromosomes May Explain Second Cancers
...as topoisomerase-IIinhibitors. These drugs work by blocking the action of an enzyme found incells known as topoisomerase II (topo II). The job of topo II is to untangleDNA strands during cell division; failure to do so is lethal to the cell. Topo II does this by making temporary breaks in DNA to allow anothe...Synthetic Detergent Found To Fight Multi-Drug Resistance
...py drugs required to treatmulti-drug resistance by blocking a drug pump in cancer cells. The researchersfound the synthetic detergent in human urine while looking at the role of thedrug pump in the kidney. "We're very surprised by these findings," says lead investigator Dr.Jeffrey Charuk of the depar...Six Football Players Died In 1997 Season: New Study
...player should make first contactwith his head when blocking and tackling. That's against the rules, but moreimportantly, it's dangerous." In 1968, 36 young men died after injuries in practices or in games.Mueller said. The drop in deaths directly attributable to football resulted fromrule changes adop......that finasteride, which lowers the levels ofDHT by blocking the enzyme that converts testosterone into DHT, might preventthe formation of prostate cancer. The National Cancer Institute (NCI) is in the midst of a large national clinicaltrial to determine if finasteride can reduce the incidence of prostate canc...Study Shows Three-Drug "Cocktail" Needed To Keep AIDS Virus Curbed
...uses, Eron said. Zidovudine and lamivudine work by blocking theenzyme that copies the genetic blueprints for the virus. "The next step will be to front-load the therapy by trying more potent medicationsinitially and giving them over a longer period, perhaps a year," he said. "Thiskind of induction and mainte......ent stroke by shoring up weak spots in arteries or blocking offaneurysms. The UB prototype provides images that are significantly clearer than canbe produced by any current system, and may allow the viewing of even the tiniestblood vessels in the circulation system, Stephen Rudin, Ph.D., UB professor ......aloxifene is an antiestrogen, a drug that works by blocking theestrogen receptors in the breast, thereby preventing the hormone estrogen fromcontributing to the growth of cancer. Jordan and other breast cancer researchersbelieve that the estrogenic properties of drugs such as raloxifene preventosteoporosis an......th inhibition." However, Filbin has found that no blocking effect occurs if the neuron isexposed to neurotrophins and MAG or myelin at the same time. The neuron must be"primed" first. Filbin co-authored the article, "Prior Exposure to Neurotrophins BlocksInhibition of Axonal Regeneration by MAG and Myelin V......the counter) can help prevent or reducesymptoms by blocking the production of histamines. People with allergy-triggeredasthma can also benefit from these medications along with prescribed cortisonesprays, which contain steroids that reduce inflammation. Though both Dorit and Jesse had undergone extensive alle......adian clock did not shift, suggesting orphanin was blocking the process thatnormally converts light into a brain signal telling the animal to wake up. "The most important signal you get to your biological clock is light,"said Allen. "There's a direct connection between our eyes and the clock. Infact,...