New study in 'Nature' demonstrates protection against cell death during heart attack
... protect it." A class of drugs already exists that blocks cyclophilin D. The most well known one is cyclosp...r. In addition to blocking cyclophilin D, it also blocks calcineurin, an agent that protects the immune system. Fortunately, there are so-called analogs of ...OHSU scientists test medication to treat involuntary weight loss
...e Neurocrine's orally-administered medication that blocks the MC4 receptor in the brain. In both cases, the animals' appetites increased and their metabolic rates decreased, ultimately resulting in the resumption of normal growth and accumulation of muscle mass. Researchers now hope to conduct clinical tria...Protein that helps skin cancer spread identified by Stanford researchers
...ri said. What's more, it appears that the antibody blocks only the cancer-spreading aspect of collagen VII. ...atients. Khavari said he could imagine a drug that blocks the collagen VII fragment being used pre-emptively to prevent skin cancer from spreading in people w...Research suggests possible blood test for multiple sclerosis
..."expressed" in proteins. Peptides are the building blocks of proteins. Participants in the study had relapsing-remitting MS, the most common form, which is characterized by attacks interspersed with stable periods. They were not taking medications for MS. The mean age of participants with MS was 29 years; ...Brain imaging studies investigate pain reduction by hypnosis
...es in brain activity suggest that hypnosis somehow blocks the pain signal from getting to the parts of the b... regions may be part of an inhibition pathway that blocks the pain signal from reaching the higher cortical structures responsible for pain perception. Howeve...Medical molecules designed to respond to visible light that can penetrate tissue
... a tumor cell. "The challenge has been that tissue blocks light so we can't signal molecules deep within the body to deliver drug therapy," says Brewer, associate professor of chemistry. Matthew Mongelli of Maywood N.J., a postdoctoral associate in chemistry, and his colleagues in chemistry and biology at V...Researchers discover link between insulin and Alzheimer's
...tion. By studying a gene abnormality in rats that blocks insulin signaling in the brain, researchers found that insulin and IGF I and II are all expressed in neurons in several regions in the brain. Additionally, researchers determined that a drop in insulin production in the brain contributes to the dege...CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
... on normal cells, which strongly suggests that CK2 blocks apoptosis only in cancer cells. Because DRB can a...hen the team added to the cancer cells a drug that blocks caspases, TRAIL-induced apoptosis was also blocked. "Our discovery that blocking CK2 makes cancer c...Protein that promotes survival of stem cells might be key to poor leukemia prognosis
...ished in the February 18 issue of Science . Mcl-1 blocks the biochemical cascade of reactions that trigger apoptosis ("cell suicide") of HSCs, according to Joseph Opferman, Ph.D., assistant member of St. Jude Biochemistry. Expression of Mcl-1 thus ensures that HSCs continue to thrive and multiply so they c...Potential drug target for treating cocaine abuse found
... drug used in the treatment of Parkinson's disease blocks the stimulating effects of cocaine and could poten...ports it back into the sending neuron. But cocaine blocks the mechanism that transports dopamine, causing it to build up and send an unceasing message of plea...Investigational transplant drug effectively preserves kidneys while avoiding toxic side effects
... though, cyclosporine indiscriminately targets and blocks other cellular signal pathways, causing serious side effects such as high blood pressure and cholesterol, which may lead to cardiovascular disease, and high kidney toxicity that ultimately leads to long-term renal failure. In addition, long-term cycl...Medication helps alcoholics control drinking
...cohol dependence since the early 1980s. Naltrexone blocks the brain's receptors for natural painkillers, known as opioids, which normally create the feeling of wellbeing associated with drinking. He explains that the benefits of naltrexone lie not so much in preventing a patient from having one drink, but ...Drugs aid weight loss among type 2 diabetes patients
...epressants. Xenical, the brand name for orlistat, blocks fat digestion in the intestines. Meridia, known generically as subtramine, is an appetite suppressant that works in the brain. According to the systematic evidence review by Dr. Susan Norris of the U.S. Centers for Disease Control and Prevention and ...New study tests amitriptyline for painful bladder syndrome
... wise choice for this syndrome as well, because it blocks nerve signals that trigger pain and may also decrease muscle spasms in the bladder, helping to cut both pain and frequent urination. An average of 75 milligrams of amitriptyline a day may begin relieving IC pain within a week. In contrast, doses in t...Promising treatments for Huntington's disease identified in UCI study
...st, the researchers combined Congo red (a dye that blocks the formation of toxic polyglutamine fibrils), cys...t, they combined SAHA with Y-27632 (a protein that blocks polyglutamine aggregation) and geldanamycin (a naturally occurring compound found to relieve Parkins...Murder, eyewitness identification and the limits of human vision
... In the Fairbanks case, a witness standing several blocks away viewed the 1997 beating of one man by four suspects. The suspects were tied to a separate fatal beating of second man, but that crime had no witnesses. The suspects, however, were tied to the murder by circumstantial evidence. The witness, wh...Leukemia drug breakthrough study in New England Journal of Medicine
...kemia. Given in pill form, Revlimid simultaneously blocks the growth of new blood vessels that nourish tumors (anti-angiogenesis) and stimulates the immune system to fight cancer cells. The study is reported in the Feb.10 issue of the New England Journal of Medicine. Nearly 90 percent of MDS patients are an...Children's Hospital Oakland opens new $5.6 million infectious disease lab
...at 5700 Martin Luther King Jr. Way, which is a few blocks north of the hospital. This new unit consists of interactive laboratories and office spaces, as well as specialized, shared facilities such as a DNA clean room and a biological safety level-3 facility (BL-3), which is one of the highest safety and se...NIAID begins enrolling volunteers for novel HIV vaccine study
...ine that stimulates cellular immunity alone either blocks HIV infection, decreases the level of HIV early in infection or both," says Anthony S. Fauci, M.D., director of NIAID. This proof-of-concept trial is designed to yield vital information on the potential efficacy of cellular immunity against HIV, alt...Sildenafil effectively treats enlarged hearts, mouse study shows
...ass says, was the focus of his research because it blocks or stops an enzyme, called phosphodiesterase 5 (PDE5A), involved in the breakdown of a key molecule, cyclic GMP, which serves as a "natural brake" to stresses and overgrowth in the heart. "We thought we could more strongly apply the brake on hypertr...