Anti-eosinophil therapy shown to be effective in treating hypereosinophilic syndrome
...ped for the treatment of asthma, anti-IL-5 therapy blocks the eosinophil growth factor interleukin-5 (IL-5). IL-5 is a cytokine critically involved in regulating several aspects of eosinophils including their production, activation and tissue recruitment. Four patients, previously dependent on a variety o...'Science' showcases research on forgetting
...y have located a mechanism in the human brain that blocks unwanted memories. This is the first time that anyone has shown a neurobiological basis for memory repression. The findings, by lead researcher Michael Anderson, associate professor of psychology at the University of Oregon, and his colleague, John D...Chagas' disease: virulence factor identified
...e macrophages and the dendritic cells, and notably blocks the production of interleukin 2 (IL-2), a cytokine necessary for T-lymphocyte proliferation, in this way exerting an immunosuppressive activity. Experimental infections with T. cruzi have been conducted in the laboratory on mice immunized beforehand...New drug combination might be more effective pain reliever
... have yet to demonstrate that glucosamine actually blocks pain. "We embarked on this study with several questions: Can glucosamine actually block pain? And, can glucosamine improve the pain-relieving powers of other drugs when the two are combined?" said Tallarida. First, the researchers confirmed that gl...Blocking selected neurotransmitter activity may decrease alcohol consumption
...viors. Researchers have found that a compound that blocks NPY activity decreases both the onset as well as t...search are the first to show that a compound that blocks NPY activity may be useful for alcohol treatment. "NPY is the most potent stimulant of feeding behav...Gleevec shows promise in treating another form of leukemia
...d the symptoms are the same, says Thomas. Gleevec blocks production of the abnormal protein, thereby preventing the growth and reducing the number of abnormal blood cells. While the drug works in CML without use of additional therapy, earlier studies of Gleevec as a single agent in previously treated Phila...New drug may help cancer patients in need of stem cell transplants, Jefferson trial shows
...ompared to those who receive only G-CSF. AMD-3100 blocks a specific cellular receptor, triggering the movement of stem cells out of the bone marrow and into the circulating blood, boosting the supply of stem cells from the bone marrow to be used in transplantation. Stem cell transplantation entails collect...DuPont-led scientists unveil key nanotechnology discovery with use of DNA
...rical properties that make them potential building blocks in a broad range of nanotechnology-related electronic applications, including highly sensitive medical diagnostic devices and mini-transistors more than 100 times tinier than those found in today's microchips. When they are fabricated, however, carb...Physical activity key to maintaining independence say University of Pittsburgh researchers
...ty through sports/leisure activities and number of blocks walked. In 1985, physical activity was objectively...eating, dressing, doing housework, walking several blocks and climbing stairs. Functional status was objectively measured using a seven-item Physical Performa...GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
...s comprising two or more amino acids, the building blocks of proteins. "Cyclic" peptides have one or more rings formed by peptide links, a bond that stabilizes the compounds and makes them less likely to break down. Currently, most compounds are tested with a method called high-throughput screening, in w...Jefferson scientists find radiation and blood vessel inhibitor more effective against brain tumors
Combining radiation with an agent that blocks VEGF, a protein that promotes the development of blood vessels and the growth of cancerous tumors a process known as angiogenesis may be more effective against brain tumors than either treatment alone, researchers at Jefferson Medical College have ...Combining medication, family counseling improves treatment outcome for men who abuse heroin
...heroin abusers' use of naltrexone, which, while it blocks the "high" associated with heroin use, is prescrib...art explained that naltrexone is a medication that blocks the "high" created by taking heroin and other opiates. It makes using these drugs less enjoyable and...Anti-inflammatory drugs speed brain recovery in Stanford animal study
...repeated the experiment but added a substance that blocks the effects of IL-6. These stem cells were able to form normal neuronal cells. In a final experiment to test the effectiveness of NSAIDs, Monje exposed rats to radiation then gave them regular doses of NSAIDs. Compared to rats that didn't get the ant...Jefferson scientists use gene therapy to restore function of damaged heart cells in laboratory
...dividuals who had suffered heart failure. The gene blocks the activity of an enzyme that is increased in such heart cells, in turn, enabling the cells to beat at normal strength. Dr. Koch and his co-workers at Duke University Medical Center in Durham, N.C., presented their findings this week at the American...Salk news: Diabetes first steps
...rt for cAMP Response Element Binding protein, CREB blocks the production of a switch protein, called PPAR-gamma, which normally promotes fat storage. By shutting off the PPAR-gamma switch, CREB insures that the free fatty acids are burned, not stored, during fasting. CREB may then contribute to insulin resi...New study shows possible role of SERMs in future menopausal hormone therapy
...ing Alzheimer's disease. At the same time, EM-652 blocks the negative effects of estrogen in the peripheral tissues, including the mammary gland and uterus. "EM-652 in combination with estrogen may offer a novel approach to treating postmenopausal women," explained Dr. Labrie. "If our findings in rats ar...Scientists identify novel enzyme with key role in leukemia protein's normal function
... relatively non-toxic compounds. Thus, a drug that blocks Taspase1 might shut down the runaway proliferation of blood cells that causes the leukemia - and might work in other cancers as well. "We'd be very interested in making an inhibitor to Taspase1, which could knock the HOX genes out of action, and test...New drug for non-small cell lung cancer shows efficacy
...." Gefinitib is a "designer" drug that targets and blocks an enzyme calledtyrosine kinase, part of the epidermal growth factor receptor. Found onthe cell surface, the epidermal growth factor receptor is over-expressedin many non-small cell lung cancers. When the epidermal growth factorresponse is activated,......nter report they have found a gene "silencer" that blocks a cancer cell's ability to repair itself after drugs and radiation cause damage. Engineered pieces of protein-encoding RNA (ribonucleic acid), the mirror image of genes' building blocks, were used to target repair proteins in cancer cells effectivel......er progression and hormone-resistance." Herceptin blocks a different but closely related growth receptor, HER-2, which is found in great abundance in about 30 percent of breast cancer, often resulting in more aggressive cancer cells that don't respond to standard treatments. The drug is also being studied ...