Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
...e estrogen receptor. "Our work doesn't provide the blueprint for the perfect replacementestrogen," said Greene, "but this collection of receptor structures -- firstestradiol and raloxifene, and now DES and tamoxifen -- offers us the best cluesto date about how to begin to design new drugs." The other senior au...Study suggests a drug treatment for abdominal aortic aneurysms
...essenger RNA for MMP-9. This messenger carries the blueprint for MMP-9 from thegene to the cellular machinery that makes the enzyme. "So doxycycline decreasesMMP-9 production," Curci says. He also showed that the drug decreased the ability of cultured white cells toproduce MMP-9 messenger RNA and MMP-9 protei...Establishing "stroke centers" in hospitals would reduce deaths and disabilities, say stroke experts
...e for such patients. The JAMA article presents a blueprint of the components necessary for hospitals to launch stroke centers and includes estimated costs for the different components, outlined in the attached fact sheet. In the article, the authors express their hope that the adoption of these recommendati...Landmark school-based 'social influences' smoking-prevention program found not to work
...tandard of rigor will be invaluable in providing a blueprint for future prevention research," Clayton says. Peterson and colleagues conclude that it may be time to take a totally new approach to smoking prevention that incorporates different theories, different intervention strategies, different venues and/or ...Widely used anti-bacterial inhibits parasites that cause malaria and toxoplasmosis
...at causes toxoplasmosis." "This finding gives us a blueprint to design an effective and safe new drug," said Craig Roberts of the University of Strathclyde, UK. Malaria affects more than 300 million people worldwide and kills an estimated 3,000 people, mostly children, each day. Although most cases originat...Cell transplants offer hope of brain repair following stroke
...ow in adults or in embryonic tissue lay down the blueprint for development of all the body's organs including the brain. They have the potential and the flexibility to grow and differentiate into the many kinds of cells needed by the human body. Until about 10 years ago, many people believed that the abili...New report links birth defects, premature birth to being overweight before pregnancy
...he United States and worldwide. "This report is a blueprint of practical answers for a healthier tomorrow for people in the United States and around the world," says Dr. Deckelbaum. We hope it will inspire health providers, community leaders, and policy makers at all levels. The March of Dimes Task Force on ...Writing nanopatterns with DNA inks
...se, the deposited DNA is not only an architectural blueprint for a structure but also the construction worker which directs where each brick goes. Because single-stranded DNA molecules have a natural pre-programmed chemical match and attract complementary molecules, we can use them to control material and devi...First longitudinal study on lesbian health
...des with the publication of Healthy People 2010, a blueprint for the nation's health that includes sexual orientation as one of six demographic categories for which health disparities exist. Other recent reports, issued by the Centers for Disease Control and Prevention, the American Medical Association, the A...Pivotal brain processor decreased in schizophrenia
...g information throughout the brain and providing a blueprint for physiological activity. Greengard won the Nobel Prize for Medicine in 2000 for his work on DARPP-32. "DARPP-32 is a key regulatory protein, involved in controlling receptors, ion channels and other physiological factors and is activated and de-ac...New UCLA program to study the possible environmental causes of cancer
...to discover subtle variations in the human genetic blueprint that predispose some individuals to develop cancer after contact with environmental pollutants. The program will explore, for example, why some individuals exposed to second-hand cigarette smoke develop lung cancer, while others do not. Bringing toge...Afghanistan's health challenge
...re infrastructure 'has the potential to serve as a blueprint for the post-conflict reconstruction for other nat...lth-care challenge has the potential to serve as a blueprint for the post-conflict reconstruction for other nations. One of the most serious threats to progress...'Reset switch' for brain cells discovered
... a neuron by the processing of its initial genetic blueprint -- called messenger RNA (mRNA). Messenger RNA is a copy of the genetic DNA blueprint for a specific protein -- such as the NMDA receptor protein -- that the cell's protein-making machin...Students of mixed races report suffering more health problems
.... "These findings offered the parents of America a blueprint for what worked in protecting their kids from harm," Udry said. "Contrary to common assumptions, Add Health found that parents -- not just peers -- were extremely relevant to their children throughout adolescence," he said. Parents trying to prevent ...How the cellular 'garbage disposal' grinds to a halt to cause Batten disease
...erstanding how a straightforward mistake in life's blueprint translates to a disease that ravages roughly 1,000 children in the United States each year has been a challenge. Now, in a paper in the Dec. 23 issue of the Proceedings of the National Academy of Sciences, a team from the University of Rochester Medi...March/April 2004 Annals of Family Medicine tip sheet
...onal family medicine organizations are releasing a blueprint for improved, patient focused care. The Future of Family Medicine Project report, published as a supplement to the March/April issue, calls for systemic changes to the U.S. health care system, medical education and clinical practice, and the developm...Northwestern Memorial launches trial to determine most effective treatment for hepatitis C
... of hepatitis C. It should provide doctors with a blueprint that will make it much easier to decide which treatment to recommend based upon a patient's individual profile." Currently, the most effective treatment for the hepatitis C virus is the combination of pegylated interferon alpha and ribavirin. Pegylat...Duke scientists identify new way to block blood vessels that feed cancer growth
...fusion of oxygen releases pent-up RNA, the genetic blueprint molecule, for HIF-1 protein which is bound up in tiny particles called stress granules. The oxygen disintegrates these stress granules and allows HIF-1 to be produced and to engage in production of growth factors. Secondarily, the infusion of oxygen ...Mouse study could aid vaccine designers
...o destroy infected cells. Their insights provide a blueprint for rational design of vaccines that induce desired T-cell responses. The findings are published in this week's Science. "If we are correct, what we've found will put rational vaccine design on a firmer footing," says Jonathan Yewdell, M.D., Ph.D., w...Angiogenesis therapy successful for peripheral arterial disease
...called a plasmid, which carried a gene that is the blueprint for a protein known as the "zinc-finger-activating" (ZFP) transcription factor. Transcription factors are proteins that switch on other genes. In the rabbits, the gene produced ZFP transcription factor that successfully activated a key blood-vess...