Tag: "cascade" at medical news

Researchers search for first sign of congestive heart failure

...as weight loss and exercise also may help stop the cascade that ultimately leads to a failing heart. He's focusing his studies on adolescents because of mounting evidence, from centers such as the Georgia Prevention Institute, that cardiovascular disease and related conditions such as high blood pressure beg...

CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide

...ISC forms, an enzyme called caspase-8 triggers the cascade of biochemical events outside DISC that eventually leads to cell death. By desensitizing the cell to TRAIL, CK2 disrupts the DISC response, which in turn prevents apoptosis and allows the cancer cell to continue growing. "The work my laboratory has ...

Protein that promotes survival of stem cells might be key to poor leukemia prognosis

...8 issue of Science . Mcl-1 blocks the biochemical cascade of reactions that trigger apoptosis ("cell suicide") of HSCs, according to Joseph Opferman, Ph.D., assistant member of St. Jude Biochemistry. Expression of Mcl-1 thus ensures that HSCs continue to thrive and multiply so they can complete the task of ...

Jefferson scientists uncover potential trigger of diabetic kidney disease

...asons these cells die in human disease and start a cascade of progressive kidney failure," Dr. Sharma explains. "If we can develop compounds to block CD36, it could potentially be a clinical intervention."Our thinking is completely novel that CD36 is a key player in causingprogressive diabetic kidney diseas...

Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find

...dary spinal cord damage the so-called destructive cascade begins within a few hours after the initial injur...e. More importantly, it stops the secondary injury cascade by preventing the neutrophils from getting into spinal cord tissues through the blood-brain barrier....

Newly identified gene cluster on mouse X chromosome provides insights into fertility

...nes to be activated, which then turns on a genetic cascade that affects the neighboring germ cells, pushing them to mature and become sperm." "Another thing that some Rhox genes could be doing is regulating the production of proteins within Sertoli cells that allow the neighboring germ cells to survive," Wil...

Cooling lessens brain damage in sick newborn babies

... University College London points out, "a chemical cascade is triggered leading to brain damage hours or days...nts they found that cooling prevented the chemical cascade from causing permanent brain damage, and developed the discovery to the point where the treatment co...

Entrepreneurism Center at UC San Diego funds commercialization of lung, shock, other devices

...tease inhibitor to block complement and thrombotic cascade activation and minimize complement activation during the filtration process. The team will test whether the glass filter still eliminates the inflammatory mediators in the presence of protease inhibitors under in-vitro conditions, and whether filtra...

Sleeping less may be related to weight gain

...hers that insufficient sleep could be leading to a cascade of disorders, few in the general medicine profession or in the lay public have yet made the connection." As younger and older Americans alike struggle with an inability to get enough sleep and to control weight, the authors stress the need to invest...

M. D. Anderson researchers discover key protein in psoriasis

...iption factors, potent proteins that can set off a cascade of events by simultaneously activating many genes. In the case of STAT3, activation leads to the production of growth-promoting and cell survival proteins. Activated STAT3 is essential in normal skin to promote wound healing. When the healing process...

Two-fisted assault on dopamine transport system may be foundation of Parkinson's disease

...xic effects of the chemical rotenone, results in a cascade of highly toxic free radicals, the destruction of microtubules that transport dopamine to the brain's movement cente, and eventual death of the dopamine-producing neuron. "This study hows how an environmental toxin and a gene linked to Parkinson's d...

UCSD researchers identify new role for drugs in prevention, treatment of atherosclerosis

...lerosis in mice, they did not know, until now, the cascade of molecular events that accomplished this in the living body. The new study in mice also demonstrated that PPAR-alpha drugs that are similar to Gemfibrizol (used to lower triglyceride levels), but much more potent, were effective as an anti-ath...

Crohn's disease treatment shows promise in clinical trial

...searcher Warren Strober, M.D., linked IL-12 to the cascade of immune system events that leads to the debilitating symptoms of Crohn's disease. "NIAID researchers have taken advantage of a potential target for preventing, early in the disease process, the devastating inflammation that excess IL-12 seems to tr...

Researchers discover potential skin cancer prevention target

...factors are potent proteins because they set off a cascade of events by activating numerous genes, which in turn lead to the production of growth-promoting proteins. Activated STATs have been observed in a wide variety of human cancers, including lymphomas and solid tumors. Because of its newly discovered ro...

Scientists identify key mechanism in estrogen's role in preventing bone loss

...sforming growth factor (TGFb) is responsible for a cascade of events that leads estrogen to prevent bone loss. When TGFb signaling in T cells is blocked, the bone-sparing effects of estrogen are lost. The findings could lead to new therapeutic approaches for preventing bone loss. Results of the research w...

Novel drug-antidote strategy provides greater control of drug action

...ctor IXa, a pivotal clotting factor in the complex cascade of biochemical events that ultimately leads to the formation of a blood clot. Past studies have shown an association between elevated levels of factor IXa and the onset of acute coronary syndrome. The researchers discovered anticoagulant aptam...

Oxygen therapy may improve vision worsened by diabetes

...es. It is caused when high blood sugar, through a cascade of events, causes damage in normal retinal blood vessels and a decrease in the supply of oxygen and nutrients. Campochiaro and Quan Dong Nguyen, M.D., the principal investigator on the study, hypothesize that the retina, when faced with a decrease i...

Enzyme prevents lung damage in premature infants

... Currently, there is no good treatment to stop the cascade of injury in which inflammation meant to heal becomes a biochemical attack on the body's own tissue. Steroids can alleviate the inflammation, but the drugs can slow brain and lung growth and impair immune function. The average hospital stay for infan...

FDA approves Enbrel to treat psoriasis

...ortant role in both normal immune function and the cascade of reactions that causes the inflammatory process of RA, JRA, psoriasis, psoriatic arthritis and AS. The binding of ENBREL to TNF renders the bound TNF biologically inactive, resulting in significant reduction in inflammatory activity. Since the pr...

Iressa news backgrounder: Testing of smart drug expands at M. D. Anderson Cancer Center

... the cell, thereby preventing the setting off of a cascade of signals that result in cellular proliferation. ... as a porthole to get inside the cell, jamming the cascade of signals found along the critical pathways. These small molecule drugs are variously known as farn...

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