Tag: "caspase" at medical news
Researchers identify pathway that may slow the progression of Lou Gehrig's disease
...r patients are dying." Dr. Przedborski notes that caspase
inhibitors would not be a miracle drug and would not cure ALS. However, he suggests that a "cocktail" of drugs that attack the neurodegenerative process at several different points--similar to the successful strategy now used to treat HIV infection--...
Cell 'suicide' enzymes are a missing link in Alzheimer's disease
...he tangles in Alzheimer's disease, indicating that caspase
cleavage of tau may play a role in tangle formatio...lecular events and to determine what role, if any, caspase
cleavage of tau has in neuronal cell death. Binder is professor of cell and molecular biology and a...
Serum caspase activity and liver fibrosis in patients with hepatitis C
...usseldorf and Hannover Medical School investigated caspase
activity levels in the sera of HCV patients, since recent studies have suggested that caspase
activation is involved in very early liver damage. Caspases are believed to mediate the key changes ...
Other highlights in the December 1 JNCI
... with celecoxib decreased cell survival, activated caspase
(mediators of apoptosis) cascades, and increased DNA fragmentation by a pathway involving death receptor induction and caspase-8 activation. The authors conclude that celecoxib appears to induce apoptosis in human NSCLC cells through the extrinsic de...
CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
... ability of TRAIL to trigger apoptosis depended on caspase
enzymes, such as caspase-8. Caspase enzymes are part of the biochemical pathway that triggers the cell to undergo apoptosis. Specifically, when the team added to the cancer cells a drug that blocks caspases, TRAIL-induced apoptosis was also blocked. ...