Choose your painkillers with care
...ly heal. Both drugs, rofecoxib (sold as Vioxx) and celecoxib (Celebrex), are often used to ease the pain of broken bones. Merck, the maker of rofecoxib, rejects the claim that healing could be impaired in people too. It pointed out a study on spinal fusion operations that found no bone healing problems in peo...New anti-inflammatory drug clears Alzheimer's provoking protein from brains of mice
... is a key step in nerve cell death. Ibuprofen and celecoxib did not activate microglia in the transgenic mice. The researchers had assumed the anti-inflammatory drugs would reduce the brain's inflammatory response caused by the amyloid deposits. The unexpected result suggests that increased immune activity...COX-2 inhibitors and the elderly
...tive nonsteroidal anti-inflammatory drugs (NSAIDs) celecoxib (Celebrex) and rofecoxib (Vioxx) were first listed on the Ontario Drug Benefit (ODB) formulary as "limited use" products on Apr. 17, 2000. The "limited use" designation indicated the products would only be covered as a benefit if previous NSAID ther...Colonoscopy far more cost-effective against colon cancer than promising Cox II drugs, study predicts
... potential effectiveness of Cox-II inhibitors like celecoxib (sold as Celebrex) and rofecoxib (sold as Vioxx) i...ministration has approved the use of high doses of celecoxib to prevent polyps in people with a rare disorder called familial adenomatous polyposis, or FAP. Now...COX-2 inhibitor could be safest anti-inflammatory drug for older people
...i-inflammatory cyclo-oxygenase-2 (COX-2) inhibitor celecoxib may have a lower risk of congestive heart failure ... a 40% increased admission risk. However, users of celecoxib had the same rate of hospital admission for heart failure as people who had never used NSAIDs. Dr Ma...Chemoprevention backgrounder: Working for a future of cancer chemoprevention
...tudy to see if twice-daily 400 milligrams doses of celecoxib can reverse damage due to smoking. "It's a biomark... and Drug Administration (FDA) approved the use of celecoxib for FAP patients, based on work conducted at M. D. Anderson and St. Marks Hospital in London. In the...Other highlights in the December 1 JNCI
...NSCLC) cell lines. They found that treatment with celecoxib decreased cell survival, activated caspase (mediat...nd caspase-8 activation. The authors conclude that celecoxib appears to induce apoptosis in human NSCLC cells through the extrinsic death receptor pathway. Cont...Penn epidemiological study shows difference in cardiovascular effects between Vioxx and Celebrex
...ciated with COX-2 inhibitors rofecoxib (Vioxx) and celecoxib (Celebrex), researchers at the University of Penns...there is a marked difference between rofecoxib and celecoxib relative to heart-attack risk," said Stephen E. Kimmel, MD, Associate Professor of Medicine at Penn ...Dec. 7 tip sheet Annals of Internal Medicine
...attack when compared with another COX-2 inhibitor, celecoxib (brand name Celebrex). Rofecoxib was also associa...ti-inflammatory drugs). It was not clear if use of celecoxib was associated with higher odds for heart attack than use of NANSAIDs. NOTE: Reporters, editors: S...Celecoxib shows surprising activity against estrogen receptors
Six months of treatment with celecoxib (Celebrex) in women at risk of developing breast c...r Center has found. The surprising insight - that celecoxib may regulate a cell's use of estrogen - could help explain the drug's observed anticancer properties...NIH halts use of COX-2 inhibitor in large cancer prevention trial
...y that it has suspended the use of COX-2 inhibitor celecoxib (Celebrex Pfizer, Inc.) for all participants in a ...ved. They were randomized to take either 200 mg of celecoxib twice a day, 400 mg of celecoxib twice a day, or a placebo for three years. The trial began in early...Special JAMA commentary on lessons learned from troubles with COX-2 inhibitors
...cal trials. "Based on data available in 2001 for celecoxib and rofecoxib, my colleagues and I concluded: 'it is mandatory to conduct a trial specifically assessing cardiovascular risk and benefit of these agents. Until then, we urge caution in prescribing these agents to patients at risk for cardiovascular ...Jefferson scientists find zinc may help prevent esophageal, oral cancers
...tary zinc were also treated with COX-2 inhibitors, celecoxib (Celebrex) and indomethacin. They found that the r...ne whether zinc in combination with low amounts of celecoxib can prevent upper aerodigestive tract cancers, including esophageal and oral cancers....Penn researchers add more evidence to demonstrate role of COX inhibitors in heart-disease risk
...proposal was based initially on his studies of how celecoxib (Celebrex) and rofeocoxib (Vioxx) worked in human ...e early cessation of a placebo-controlled trial of celecoxib (Celebrex) in December 2004 by the National Cancer Institute (because of an excess incidence of hea...Study estimates number of excess cases of coronary heart disease caused by Vioxx
...ompared with other (NSAIDs) or the COX-2 inhibitor celecoxib (Celebrex), a drug commonly used as an alternative.... Patients had received various NSAIDs, including celecoxib (around 40,000 users), ibuprofen (just under a million users), naproxen (around 435,000 users), and ...More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
...tients were randomly assigned to receive 200 mg of celecoxib (Celebrex; Pfizer Inc., New York) [n= 136], or 25 ...as increased significantly by refecoxib but not by celecoxib or naproxen." "these results suggest the need for careful monitoring and control of blood pressure w...Celecoxib safe for short-term use in patients with cirrhosis
...GFR and increased serum creatinine levels. Neither celecoxib nor the placebo affected the diuretic or natriuret...retic responses to furosemide. Interestingly, both celecoxib and naproxen significantly reduced plasma renin activity after furosemide administration. "These res...Study shows patch therapy may be as effective as oral medications
...plying the lidocaine patch 5% (Lidoderm) or taking celecoxib (Celebrex) 200 mg per day. In this study, results ...Lidoderm) group (N=56) and 62 % of patients in the celecoxib (Celebrex) group (N=63) experienced a 30 % or greater improvement in pain intensity. A 30 % or grea...