Drug's Effect On Chromosomes May Explain Second Cancers
...” Next, they looked for the effect in cancer cells grown in the laboratory.Again, etoposide damaged t...eed more data on what’s actually happening in cells and on whatthe downstream consequences are of telomere-specific damage.”...New Treatment Targets Most Malignant Brain Tumors
...es the main tumor mass, it cannot removethe cancer cells around the tumor that have infiltrated normal brai...rrying the radioactive Iodine homed in on thetumor cells and killed them. Other groups have attempted the same direct injection technique withlittle ...Synthetic Detergent Found To Fight Multi-Drug Resistance
...highlevels in the cell membranes of certain cancer cells that are resistant to awide variety of anti-cancer drugs. Tumors that contain a high content ofP-glycoprotein fail to respond to chemotherapy because the pump rapidly removesthese drugs from cells, preventing their killing action. The pump is also fo......connective and other tissue--that is released when cells called osteoclastsfunction in the breakdown and resorption of bone tissue. It is a marker of boneresorption. These investigators wanted to determine whether NTx might act as amarker for bone metastases in advanced prostate cancer. They took sera ...Health Risk To "Cigarette Babies" Is Neglected, Duke Scientist Charges
...e of signals that tell the sensitive growing brain cells howto "wire" their connections. However, nicotine ...manently miswire itself. Nicotine also kills brain cells outright by causingthem to "age" prematurely and die, said Slotkin. Nicotine causes similar ...Pioneer In Nuclear Medicine Wins Lifetime Award
... long half lifeallowed researchers to study single cells in test tubes, thereby revolutionizingbiochemistry; but Wagner needed more high-energy isotopes.) He led a resurgenceof interest in the shorter-lived isotopes produced by cyclotrons, which, unlikeCarbon 14, had the high energy needed to escape the bo......becomes a "languagespecialist," in which its nerve cells wire themselves to perceive distinctionsbetween different types of sounds in its native language. FOR ADDITIONAL INFORMATION BEFORE JUNE 22 Please feel free to call Ben Stein of the American Institute of Physics at301-209-3091. To read the abstract...Injecting Drugs With Sound Waves
...aid the introduction of genetic material in living cells (3aBV6). Pierre Mourad of the University of Washington (206-543-6921) will describe thetechnique of ultrasound enhanced thrombolysis (UET)--the use of ultrasound todestroy blot clots everywhere in the body (5aBVb1). George H. Harrison of theUniver...New Study Designed To Improve Outcomes In Women With Metastatic Breast Cancer
...an immune response, we will destroy residual tumor cells thatremained following chemotherapy." Foon and Don...e of chemotherapy and growth factors. Thepurified cells are frozen in liquid nitrogen for later use. Metastatic breast cancer recurs in up to 90 per...Crystal Structure Of gp120 Reveals HIV In Action
...that unfolds as HIV penetrates the linchpin-like T cells of the immune system.Now, an unprecedented peek at that process -- a viral surface glycoproteincaught in the act of binding a CD4 T cell receptor -- graces the covers of boththe June 18 issue of Nature and the June 19 issue of Science magazines. ...Study Reveals Possible Clue For Racial Differences In Prevalence Of High Blood Pressure
...ic oxide, a small molecule released by a lining of cells on the inner wallsof blood vessels, "signals" the vessels to dilate and increase blood flow toskeletal muscles, such as those in the arms or legs, when they may be needed torespond to a stressful situation. The finding may help pinpoint why blacks ar......eukin-6 (IL-6) andprostaglandin by vascular muscle cells in vitro. They also inhibit the inductionof an enz...IL-6 andprostaglandin) are then secreted by muscle cells of the vessel wall, therebysustaining the inflammatory reaction. The penultimate step in this pathol...International Panel Evaluates Testing For Drug Resistance In HIV
...ure the levels of HIV or of CD-4 cells, the immune cells primarily targetedby the virus--not by resistance testing. Drug resistance is a significant cause, but not the only cause of treatmentfailure. Other causes that might be considered include the patient's adherenceto the treatment regimen, limited d......ally. "The highly targeted drug eliminatesleukemia cells in mice, and will be used for the first time in hu...ith chemotherapy aimed at killing rapidly dividing cells or they have undergonebone marrow transplantation aimed at replacing their diseased marrow. ...Many Gay Men Infected With HIV Are Opting To Delay Treatment, Despite Availability Of Drugs
... of infection because the virusenters these immune cells and kills them--were a very good predictor of whowould be on combination therapy, according to Stall. Findings showed 80 percentof persons with CD4 T cell counts of less than 200 were following combinationtherapy, while only 40 percent of those with...Scientists Report Cancer Fighting Drug As Possible Treatment For Multiple Sclerosis
...ic to CNS myelin and to the myelin-producing brain cells calledoligodendrocytes, which are a prime target o...the treatment ofMS, the authors used immune system cells called myelin autoaggressive T cells,which many scientists think play a role in MS. Liedtke and co-w...World's First Producer To Repair Brain Damage From Stroke
...igator on this trial. "Use of manufactured cells to reverse brain damage removes the ethicalconcern...urons to ensure there are 2 million or more viable cells to transplant. After the manufactured neurons are transferred to a long-needledsyringe, a su...Immunosuppressive Treatment Is Important For Sufferers Of Rheumatoid Arthritis
...of whom 42 developed a lymphoma (a cancer in which cells of lymphoid tissue, found mainly in the lymph nodes and spleen, multiply unchecked). The authors found that there seems to be a strong association between the effect that rheumatoid arthritis has on the immune system of sufferers and the increased r...Epilepsy Drugs Useful To Treat Alzheimer's, Studies Find
...eimer's and other dementias develop as their brain cells getsick and die. The patients' memory and comprehension deteriorate,they become confused and disoriented, and ordinary tasks becomeimpossible. Nine out of 10 patients have significant behavioralproblems at some point, says Tariot, professor of psychi...Novel Therapy To Treat Lung Cancer Patients Enrolling Patients At UCSF Cancer Center
...apy has been shown to inhibit the growth of cancer cells inanimal laboratory studies. The antibody to VE...tting off itssupply of nutrients and oxygen. Many cells produce VEGF to help stimulate the growth and migration of bloodvessels that supply nutrients to cel...