Tissue engineers steering stem cells to produce bone, cartilage
...ls with a specific growth factor that helps direct cellular differentiation, Williams has prodded the stem cells into forming what lab tests indicate are osteoblasts (cells that develop into bone) or chondrocytes. The cartilage samples show the proper gene expression and a cartilage-specific extracellular mat...International Congress of the Transplantation Society beginning Sunday
...ions covering such topics as transplant tolerance, cellular transplantation, gene therapy, transgenics and xenotransplantation will be presented in scientific sessions. Following a pre-congress symposium on living donor kidney transplantation, the congress officially begins at 6 p.m. on Sunday with opening c...NIEHS announces $20 million, three-center effort to pin-point environmental triggers of Parkinson's
... call (404) 727-3727. The center will develop new cellular and animal models to study gene-environment intera...teins that package dopamine within nerves, and the cellular machinery that degrades abnormal proteins. The University of California at Los Angeles, with Marie...Can an aspirin a day keep atherosclerosis at bay?
...rosclerosis is associated with increased levels of cellular inflammatory signals called cytokines. Plaque formation is also associated with increased levels in the aorta of a protein called NF-?B that controls the formation of these cytokines, stimulates the growth of immune cells and the accumulation of low...PET/CT scanning now available at Fox Chase Cancer Center
...tron emission tomography and it detects changes in cellular function how cells are utilizing nutrients like sugar and oxygen. Areas with a high degree of metabolic activity have a greater chance of being cancerous. A computerized tomography or CT scan allows physicians to see the internal or anatomical str...Study finds new target for development of anti-cancer drugs
... km23 is responsible, in part, for the movement of cellular proteins along microtubules, the "highways" of the cell. The cellular proteins, or "cargo," are actually driven along the microtubules by "motors" in the cell. One such m...Study sheds light on cause of an AIDS treatment side effect
...n can result in distortion or dysfunction of other cellular processes. HAART is a combination of potent antiretroviral drugs such as protease inhibitors and nucleoside-analogue reverse transcriptase inhibitors (NRTIs). Researchers have known for many years that NRTIs in HAART cocktail regimens can directly ...Chemists show proteins behave differently inside cells than they do in water solutions
...dentify genes, scientists hope to create models of cellular metabolism, which would advance understanding of h... and illness, Pielak said. "But to make a model of cellular metabolism that would run in a computer, you need to know how tightly these proteins bind to one ano...Gene therapy promising for preventing restenosis
...ues theorized that by injecting the gene for extra cellular superoxide dismutase (EC-SOD) into damaged blood vessels, they could control free radical damage and thereby short-circuit the process that leads to restenosis. In the study they tested this hypothesis by using a deactivated virus to deliver EC-SOD t...UCSB neuroscientist to receive award
...esearchers conduct cutting-edge research examining cellular and molecular mechanisms underlying the normal development and function of the nervous system, as well as many neurodegenerative conditions and behavior. These include age-related macular degeneration; retinal detachment, reattachment and recovery of...American Thoracic Society Journal news tips for September (second issue)
...ut of 59) had an abnormal accumulation of mucus or cellular debrispresent in their lower airways. Twenty-seven of the dogs (46 percent) were classified as moderately or severely affected. The authors said that sled dogs can sustain speeds of up to 15miles per hour and endurance dogs can cover 120 miles per ...Gene found that helps nerve cells survive by preventing cell suicide
...l stress, and toxins. Hsp27 directly inhibits the cellular proteins that trigger programmed cell death. In laboratory dishes and in rat models, Woolf and his team showed that, if the Hsp27 gene is delivered to young nerve cells using gene therapy with viral vectors, the cells are able to survive injury just ...Fred Hutchinson receives $12.7 million to lead prostate-cancer consortium
...combinations of existing drugs, also may block the cellular processes that allow cancer to grow. Project leaders: Martin Gleave, M.D., professor of surgery and director of clinical research; and Colleen Nelson, Ph.D., assistant professor of surgery and head of the Gene Array Facility, both of the University o...GlaxoSmithKline Drug Discovery and Development Award 2002
...ted by HIV by blocking the synthesis of one of the cellular proteins a coreceptor that is necessary for HIV entry into human cells, but not necessary for normal functioning of immune cells. A different approach is to interfere directly with the capability of the virus to grow in human cells. Nan-Sook Lee,...Fred Hutchinson oversees two grants of nearly $8 million to develop blood test for breast cancer
...ols that provide information about the genetic and cellular characteristics of their cancer and how it will behave," she said. The central focus of the DoD project, called the Center for the Evaluation of Biomarkers for Early Detection of Breast Cancer, will be to develop and test a panel of serum biomarkers ...Preliminary study shows high-dose coenzyme Q10 slows functional decline in Parkinson's patients
...ponent of the electron transport chain which makes cellular energy and as a molecule with antioxidant and pro-oxidant properties," Haas said. "Recently, several rare mitochondrial diseases affecting younger people resulting from coenzyme Q10 deficiency have been described. These patients may respond dramatic...20% of mammogram-detected cancers are in situ lesions of unknown aggressiveness
...ors said. Pathologists categorize DCIS by size and cellular features including nuclear grade, from low to high. It is almost always treated with surgical excision of the tumor, whether by lumpectomy alone, lumpectomy followed by radiation or by mastectomy. The authors noted that some women likely benefit from...UCSD cancer researchers develop new anti-leukemia strategy
...oach, generally known as adoptive immunotherapy or cellular therapy, are reported in the October issue of the journal Biology of Blood and Marrow Transplantation. "For reasons that are not yet entirely clear, leukemia cells fail to trigger immune responses," said the paper's senior author, Edward D. Ball, M.D...UNC forms Conte Center for multidisciplinary schizophrenia research
...enter also aims to develop a model for genetic and cellular influences of the GABAergic interneurons, which regulate the neural pathways most closely associated with the development of schizophrenia."The plain and simple reality is that we do not know how or by what mechanism the brain develops abnormally in ......lar to water), tissue acidosis can cause a drop in cellular pH below 6.0 closer to that of household vinegar. When the cellular environment becomes acidic, both VR1 and a second nociceptor - acid sensing ion channels (ASICs) - a...