Tag: "cerebrospinal" at medical news

Nanoscale diagnostic sets sights on Alzheimer's

...t have the sensitivity required to detect ADDLs in cerebrospinal fluid. BCA could eventually be configured to detec... predicted some of these ADDLs would leak into the cerebrospinal fluid, but until now we couldn't detect them. Thanks to the extraordinary sensitivity of the BCA it'...

New test is first step in early detection of Alzheimer's disease

...s developed at the University, can detect in human cerebrospinal fluid (CSF) miniscule amounts of a toxic protein t...rotein is only five nanometers wide and present in cerebrospinal fluid at very low concentration, making it very difficult to detect. Our BCA technology, which is a ...

Surgery without the scapel: U. Va. Health System marks fifteenth anniversary of Gamma knife

... risks of open surgery such as hemorrhage, leaking cerebrospinal fluid and infection. "The Gamma Knife uses 201 highly-focused beams of a radioactive isotope, Cobalt 60, to produce biological effects on brain tissue," explained Dr. Ladislau Steiner, director of the Lars Leksell Gamma Knife Center at U.Va. an...

Brain inflammation found in autism

...n the brain tissue were corroborated by studies of cerebrospinal fluid obtained from six children with autism (ages...t is conceivable that signs of inflammation in the cerebrospinal fluid could one day be used to diagnose autism, or even that doctors could treat inflammation to pre...

Brain's immune system triggered in autism

...ins, called cytokines and chemokines, found in the cerebrospinal fluid - the clear substance that surrounds, bathes... says Pardo. Cytokine and chemokine levels in the cerebrospinal fluid also were abnormally elevated in patients with autism. "These findings suggest that the ...

Jefferson neuroscientists studying new type of Alzheimer's drug to halt disease progression

... amount of amyloid in the central nervous system's cerebrospinal fluid, which bathes the brain and spinal cord. To date, there have been no serious side effects related to Alzhemed reported, although some people have had mild, transient nausea or vomiting. "Presumably," Dr. Gandy says, "an Alzheimer's patient woul...

Improved acute lymphoblastic leukemia treatment offers hope for eliminating irradiation

...hecal chemotherapy the drugs are injected into the cerebrospinal fluid-filled spaces between the thin membranes covering the spinal cord. The researchers base their conclusion on results of a study of ALL treatment at St. Jude called Total Therapy Study XIIIB, which are reported in the Nov. 1 issue of the journal...

New hope for ALS seen with genetic techniques, growth factors

...ly implanted needle. The compound was added to the cerebrospinal fluid, which constantly "washes" the entire brain and spinal cord. "When VEGF was administered one month before the disease symptoms showed up," Storkebaum says, "treatment delayed the onset of paralysis, improved motor performance, and prolonged li...

Infection, not lack of oxygen, plays larger role in premature infant brain injury

...al cultures of samples from the premature infants' cerebrospinal fluid, blood and trachea. Researchers found a two- to four fold increase in the rates of PVL among those premature infants with an infection, tested positive by culture samples. The rates of injury were independent of the type of infection - more t...

Promise of stem cells amplified

...side hollowed-out spaces in the brain that contain cerebrospinal fluid. Several groups of researchers have watched these cells mature into what look like neurons. But the true test of a neuron's function--electrical conductivity--had not yet been seen. Iver Langmoen, MD, and his colleagues harvested the adult neu...

National Institute on Aging, industry launch Alzheimer's disease neuroimaging initiative

...identify additional biological factors from blood, cerebrospinal fluid (CSF), and urine samples. "The key challenge here is to identify critical markers that respond to treatments aimed at slowing the progression of mild cognitive impairment and Alzheimer's disease," says Michael W. Weiner, M.D., the study's Princ...

Endoscopic approach best for repairing bone defect between brain, nasal cavity

...g to the open procedure. The condition, called cerebrospinal fluid rhinorrhea, results when trauma or high pres...ly causing meningitis and even death. When the cerebrospinal fluid escapes through the nose, loss of protective fluid around the brain can cause headaches as wel...

Highlights of Washington University Alzheimer's Research at National Conference

...acteristic of Alzheimer's, is being studied in the cerebrospinal fluid of middle-aged adults who have a parent with the disease to see whether it may indicate risk for later Alzheimer's onset. Preliminary findings suggest measuring these levels may help predict onset of the disease. In a mouse model of Alzheimer...

CNS cancers and other diseases: Using proteomics to identify unique protein 'fingerprints'

...ve identified specific protein fingerprints in the cerebrospinal fluid (CSF) of humans that enable them to differentiate between cancers, both primary and metastatic, and non-cancerous diseases of the central nervous system (CNS). This finding offers promise of a more rapid, less invasive, and more accurate method...

First biomarkers to diagnose Lou Gehrig's disease found in CNS

...c tool, Dr. Bowser and his colleagues examined the cerebrospinal fluid (CSF) from 25 people recently diagnosed with ALS and 35 control subjects without ALS. Some of the controls had no neurological symptoms and some had other neurologic diseases that present to the physician with symptoms similar to ALS, including...

Newborn brain injuries stem from infections, not delivery

... more likely to have evidence of infections of the cerebrospinal fluid, blood and windpipe. "Our study refutes the fact that white matter injuries are caused by delivery," says Ernest Graham, M.D., senior study author and assistant professor of gynecology/obstetrics. "The biggest association with these injuri...

Moderate alcohol use may be associated with brain shrinkage

...lcal size void areas of the brain containing only cerebrospinal fluid. Participants self-reported alcohol consum...r and sulcal areas, as these areas are filled with cerebrospinal fluid," Ding said. "Therefore, an increase in ventricular and sulcal size indicates a reduction in ...

A new technique detects earliest signs of Alzheimer's in healthy people

...of certain Alzheimer-related proteins found in the cerebrospinal fluid, to get an even more diagnostically specific assessment," says Dr. de Leon, who is also Director of the Center for Brain Health at the William and Sylvia Silberstein Institute for Aging and Dementia at NYU and a research scientist at the Nathan...

High levels of immune protein in infant brain linked to SIDS

...Cytokine levels can be checked by examining blood, cerebrospinal fluid and amniotic fluid, said Kadhim. He also said that no studies have yet correlated the levels of cytokines in the brain with those in peripheral blood in SIDS infants. Some believe that a combination of three conditions is necessary for a SIDS d...

New vaccine tested in animals may hold hope for Alzheimer's patients

...hich were found in blood and, in lower amounts, in cerebrospinal fluid (CSF). Between 22 and 42 days after immunization, levels of amyloid beta protein dropped in the CSF and increased in the blood, suggesting that the antibodies bound to amyloid beta protein and increased its slow release from the CSF to the bloo...

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