Substance from Grapefruit Juice May Make Medications Safer
...ave found. These drugs include nearly all calcium channel blockers (used to control blood pressure) and some immunosuppressants, sedatives, and protease inhibitors (used to treat AIDS). Although the "grapefruit juice effect" was discovered serendipitously almost a decade ago when scientists gave volunteers...Antimicrobial "Bug Spray" Found In Human Lung Cells
...nozzle" on a similar bug spray. "That nozzle is a channel on the surface of lung cells called CFTR, and we already knew that CF disrupts it," says Ko. In a study funded by the National Institute of Diabetes and Digestive and Kidney Diseases and the Cystic Fibrosis Foundation, Ko exposed two batches of lung ...Unique Interactive Health Kiosks Distributed In Michigan
...For example, a person using the prostate screening channel could be made aware of free screenings or health fairs in the area. Public health and medical specialists, computer programmers, graphic artists and Hollywood Screen Writers Guild writers joined forces on the project. "Studies have shown that, comp......hat calcium antagonists (preferred term forcalcium channel blockers) may pose risks for certain people, including thosewith diabetes and coronary heart disease. Past studies of short-acting calciumantagonists have also found increased risk of cardiovascular complications. Itwas thought that the longer-acti...Could Cardiovascular Drugs Be Linked To Suicide?
(Use of calcium channel blockers and risk of suicide: ecological findings ...significant correlation between the use of calcium channel blockers and the incidence of suicide (that remained significant when differences in cardiovascular ...Diuretics And Beta-Blockers Are Best Drugs To Combat High Blood Pressure, Study Finds
...a small arsenal of newerdrugs -- including calcium channel blockers, ACE inhibitors and alpha-blockers -- to ...ocker gave the lowestaverage pressures and calcium channel blockers the highest," says H. Mitchell Perry Jr., M.D., professor emeritus of medicine at the Schoo...Neurotransmitter-Induced Electrical Activity Identified As Key Regulator Of Synaptogenesis
... cord cultures were treated with calcium channel antagonists and again, receptor clustering was strongly reduced. The data suggest the following model for postsynaptic membrane formation: Initially glycine receptors are diffusely distributed in the neuronal ...National Office Of Drug Safety Is Needed, Experts Say In JAMA
...about the safety of a group of drugs calledcalcium channel blockers, which are used in the treatment of high bloodpressure. Research has implicated the drugs in connection with cardiovasculardiseases, stomach and intestinal bleeding, cancer and brain damage and memoryloss. Moore is with the Center fo...New Data Show Dangerous Interaction Between Blood Pressure Drugs
...ressure medication from mibefradilto other calcium channel blocker (CCB) drugs to control their high bloodpre...cal careunits. Mibefradil is a new type of calcium channel blocker drug released in theUnited States in mid-1997 for the management of high blood pressure and ...Physicians Slow To Adopt Newer Drugs For Atrial Fibrillation
...lthough prescriptions for beta blockers andcalcium channel blockers increased during the study period. Digox... limitations not found in beta blockers andcalcium channel blockers. For example, patients taking digoxin may be morelikely to experience shortness of breath ...A Note of Caution: Be Careful When Mixing Grapefruit Juice With Rxs
...ream. These drugs include antihypertensive calcium channel blockers(i.e., felodipine, Plendil and HIV-protease inhibitors (i.e., saquinavir,Invirase). In a study* published in the April 1999 issue of Pharmaceutical Research, anAmerican Association of Pharmaceutical Scientists (AAPS) publication, Dr. AndreaS...Advertising May Influence Physicians' Choice Of Blood Pressure Drugs
The increase in the use of calcium channel blockers and ACE inhibitors for thetreatment of hy...of a chemical that constrictsarteries, and calcium channel blockers, which reduce the heart rate and relaxblood vessels. In spite of the scientific evidence fa...Balloon Procedure In The Brain? Longest Follow-Up To Date Shows Good Results
...d-up, against thevessel lining and opening a wider channel for blood flow. Although angioplasty has a high technical success rate, it still carries risks. In the stroke study, one patient died of a ruptured blood vessel at the time ofthe procedure, and another patient had a blood clot near the site of theor...Discussion about learning processes reopens
...molecule for theformation of LTP: it is a receptor channel for the excitatory neurotransmitterglutamate. Dr. ...o succeeded in knocking out a gene for thereceptor channel and thus prevented the occurrence of LTP in geneticallymanipulated mice without affecting neuronal t......1 before); and 57 percent werestill taking calcium channel blockers (50 percent before). These drugs aregiven by cardiologists to fight the chest pain associated with clogged arteries. "There may be good reasons for continuing to take these drugs in some cases,"says Dr. David Holmes, a Mayo Clinic cardiolo...UI study advances understanding of antimicrobials and cystic fibrosis-related infection
...he absence or malfunction of a specializedchloride channel in the cystic fibrosis airway causes the increased saltinessand that treatment could be based on correcting this salt imbalance. In addition to Travis and Welsh, the other UI investigators for theantimicrobial study included Barbara-Ann D. Conway, Ph...UCSF finding could lead to a new class of painkillers
...nsing neurons, or nociceptors, by enhancing an ion channel known as TTX- RINA, which sensitizes the pain-sens...ds on PKC to prompt a full effect on the TTX-RI NA channel in a critical group of pain-sensing neurons, the researchers said. The researchers further demonstra...Laser heart treatment shown to be safe and effective at lowering pain associated with heart disease
...tdrugs such as nitrates, beta blockers and calcium channel blockers (101). The researchers found that after 12 months, angina improved at least 2 classes,based on the Canadian Cardiovascular Society angina scale, in 72 percent of theTMRpatients compared to 13 percent of the medically managed patients. "In l...A new ion channel involved in cell proliferation: evidence for its oncogenic potential
...sence of EAG outside its normal location. The ion channel with this property carries the name of a mutant of...(Drosophila melanogaster) in which a defect in the channel protein causes theflies to rhythmically move under ether: Ether--go-go (EAG). The equivalent ratand ...Abstemious mice offer hint at molecular target for treating alcoholism
...urotransmitter, prompting the receptor to keep its channel open longer thannormal, which leads to the release...trigger. The outcome isthat the receptor keeps its channel open even longer, allowing still moresignals of inhibition to flow into the central nervous system. ...