Tag: "channels" at medical news
Calcium-dependent potassium channels as target to increase drug delivery to brain tumors
...nstitute modulated the calcium-dependent potassium channels
of blood vessel cells to increase permeability of ...rough protein structures called channels. Specific channels
permit passage of specific ions, and gates open and close to regulate the flow. While some gates are...
Does your brain shutdown with Alzheimer's?
...her. When these plaques touch healthy brain cells, channels
on the cell surface open up to let in a flood of c... to normal. Some of these drugs are known to block channels
that allow chloride ions to leave the cell, so an outward flow of chloride ions must be helping to d...
Common diabetes drug causes arteries to spasm, endangering heart
... without the receptor, had no functional potassium channels
in their smooth muscle, leading to calcium influx ...hat surround arteries.. Drugs that block calcium channels
reduced the frequency of coronary episodes. "We found that this receptor plays a pivotal role in the...
Wake Forest researchers find brain region 'exquisitely' sensitive to alcohol
...isruption later in sleep. Godwin said that the ion channels
underlie normal sleep spindles are functioning nor...ods of human sleep that are less restful. The ion channels
are pores or passageways through the cell membranes of the neurons in the brain. Godwin and his coll...
Study finds a mouse model for episodic neurological disorders
...ral times a day. The mutation affects calcium ion channels
tiny "gates" in cell membranes that control movement of electrically charged calcium ions into and out of cells. The movement disorder caused by this mutation is known as tottering syndrome in mice. The symptoms in tottering mice are similar to th...
Reducing side effects of retinoic acid cancer treatment
...us. Once in the nucleus, CRABP-II binds to RAR and channels
RA to it, thereby activating the transcription factor to turn genes on or off," explains Noy. Noy has found that CRABP-II greatly enhances the transcriptional activity of retinoic acid receptors by directly targeting RA to them. Therefore, she has be...
Pivotal brain processor decreased in schizophrenia
...ry protein, involved in controlling receptors, ion channels
and other physiological factors and is activated and de-activated ultimately by neurotransmitters that are implicated in the development of schizophrenia," Greengard said. "A reduction of DARPP-32 required for functions in the brain could contribute ...
The Lancet neurology press release
...anisms by which mutations in genes that encode ion channels
may cause the attacks. Gene patenting-diagnosing the problem The US Patent and Trademark Office is currently processing patent applications for 50 000 DNA sequences. The companies applying for the patents hope that their sequences will turn out to ...
OHSU receives $7.8 million NIH grant to develop first ultrasound to also deliver heart treatment
... hockey stick when fully extended, with ultrasound channels
on the side of the tip. The device will include Do... retain the hockey-stick shape with the ultrasound channels
positioned on the tip offering a smaller 2-D view, but a higher frequency ultrasound. This device wi...
Ouch! The receptors mediating acidic pain sensation
...oth VR1 and a second nociceptor - acid sensing ion channels
(ASICs) - are activated. In previous experiments in mice, scientists have found that the activation of VR1 requires extremely severe acidification - pH less than 6.0. This suggests that another pain sensor plays a role in nociception, specifically at...
'Control valve' within heart cells could protect body during heart attacks
... says. "If we can determine how mitochondrial ion channels
regulate energy in heart cells, we may be able to protect the heart against life-threatening arrhythmias and other cardiac diseases."...
Heart gone haywire blamed in some sudden infant deaths
...ectrical channels, he says. The electrical or ion channels
are proteins critical to orchestrating the electrical signals that prompt the heart to squeeze (beat) and refill between each heartbeat, says Ackerman, who is also director of the Mayo Clinic's sudden death genomics lab and the long Q-T syndrome clin...
Genetics of familial atrial fibrillation revealed, Science researchers report
...r long QT syndrome does the opposite. Cardiac ion channels
have diverse functional behaviors, which can lead to different types of cardiac disorders, Chen and Xu explained. Several small hereditary AF families and some individuals with isolated cases OF AF did not have KCNQ1 mutations, according to the a...
On the horizon of glucose monitoring: A review
...e uppermost layer of the skin. This causes aqueous channels
to form through which small molecules, such as glucose, can diffuse. More studies will determine the effect of repeated ultrasound application to human skin. "In conclusion, several promising approaches are currently under investigation to make gluco...
...lling muscle cells to contract, are generated when channels
in the membrane open, allowing ions to flow across...sing two drugs: adenosine, which opens some of the channels
that transport potassium ions in and out of the cell, and lignocaine (known as lidocainein the US), ...
Hopkins' Peter Agre receives 2003 Nobel Prize in chemistry
... determined the spatial structure of cell membrane channels
that control passage of salts. The discovery of th...ing -- at the molecular level -- of malfunctioning channels
associated with many diseases of the kidneys, skeletal muscle and other organs. Working from this ba...
Stroke treatment may come from physiological determinations not time frame, says Pitt
...blood flow in the affected area through collateral channels
and drugs or interventions aimed at lessening the damage produced by blocked vessels through neuroprotection. This can even include brain bypass surgery, a novel approach developed at the University of Pittsburgh. "The goal in acute stroke therapy is...
Rochester chosen to focus on rare neurological diseases
...hies" to describe diseases caused by abnormal cell channels
or gates that regulate the levels of crucial chemicals such as sodium, calcium, and potassium in our cells. Griggs' center will focus on three channelopathies: periodic paralysis, episodic ataxia, and nondystrophic myotonias. Patients affected by th...
Genomics research: New genetic 'hit list' may underlie susceptibility to sudden cardiac death
...s in one or more of the genes that program the ion channels
of the heart. The ion channels
are "electrical tunnels" that produce and control the heart's electrical activity. A key finding of ...
Tiny nanotube antennas may yield better signals in cell phones, televisions
...hones that allows listeners to switch to different channels
for clearer signals and to prevent others from eavesdropping. Arrays of the tiny tubes could also process image pixel data, leading to improved television images, including flat-panel displays, according to Kosko. The tubes also have the potential t...
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