Alzheimer's drug improves memory of MS patients
..."But evidence suggests that there is a decrease in cholinergic activity, likely resulting from the disruption of cholinergic pathways by the demyelination and axonal damage to the nerves that occurs in MS." In an accompanying...New data show SPIRIVA significantly reduces COPD exacerbations and related health resource burden
...geting of a dominant reversible mechanism of COPD cholinergic bronchoconstriction. SPIRIVA helps COPD patients breathe more easily by opening narrowed airways and helping to keep them open for 24 hours. According to treatment guidelines of the Global Initiative for Chronic Obstructive Lung Disease (GOLD), long-...Preliminary results are promising in Alzheimer's gene therapy trial
...urgically implanted into a deep brain region where cholinergic cell degeneration occurs in Alzheimer's disease. The cholinergic system is important in memory and cognitive function. Patients received the implanted grafts in tar...UCSD's Dr. Leon Thal to receive Potamkin Prize, one of neurosciences' highest honors
...g and dementia, he began aggressively pursuing the cholinergic hypothesis of Alzheimer's disease in the 1970s. A...to explore alternative and novel ways to treat the cholinergic deficit of Alzheimer's disease using other compounds and routes of administration. The importance o...American Thoracic Society Journal news tips for November 2003 (second issue)
... placebo (depending on the crossover). (PHYS is a cholinergic alkaloid obtained from the Calaban bean which is produced by a West African perennial shrub. PHYS has been used for some time in the treatment of glaucoma, as well as for atropine and organophosphate intoxication.) During the last one-third of the ...An anti-nicotine drug reduces the rewarding effects of alcohol
... other research findings, shows that the nicotinic cholinergic system is a promising one for evaluation as a pharmacotherapeutic target in alcoholism." Kranzler cautioned that "mecamylamine is not particularly well tolerated in high doses however, other, possibly more selective drugs that are active at the nic...Animal studies prove hormone replacement therapy improves memory, report Pitt researchers
...arning and memory, nerve cells in the brain called cholinergic neurons are essential to the process, suggest anim...aries removed and some of the animals had specific cholinergic neurons destroyed. A few weeks after surgery, most of the animals were put on estrogen replacement t...Drug reduces hallucinations and improves cognitive performance for Parkinson's patients
...required to investigate the potentially reversible cholinergic deficits in this patient group and their likely involvement in neuropsychiatric symptomology....Alcohol and nicotine: A deadly duo
...ecific connections on brain cells called nicotinic cholinergic synapses. Blockade of these synapses appears to r...where it exerts its psychoactive effects. Because cholinergic blockade by mecamylamine would be expected to slow the normal movements of alcohol and other ingeste...Multimillion-dollar pain research center funded at Wake Forest
...Those drugs act on cells in the spinal cord called cholinergic cells, the same kinds of cells affected by nicotine. One of these types of drugs, called metanicotine, is patented by Eisenach and Wake Forest University School of Medicine and is made in Winston-Salem by Targacept Inc. Animals, like humans, will ab......st of the motherboard. This ERC cell loss, not the cholinergic deficit, appears responsible for the early memory changes in MCI and mild AD. According to Dr. DeKosky, the increase in ChAT in MCI demonstrates the brains ability to compensate in one area for deficits in another to try to maintain normal function. ...Brain's efforts to save itself during Alzheimer's may backfire
...ogy of Alzheimers and studies the deterioration of cholinergic neurons. Mufson examined the brains of the transge...nic mice and found that they have 70 percent fewer cholinergic neurons in the horizontal limb of the diagonal band of Broca, similar to what happens in humans with......ts carrying an ApoE4 allele may have a more severe cholinergic deficit than those who do not. "The reports of associations between ApoE4 genotype, gender and response to cholinesterase inhibitor therapy in AD patients are conflicting. In this recently completed study, a secondary analysis showed that the treatm...New evidence suggests reconsidering causes and treatments for schizophrenia
...ti-facetted study that re-examines the role of the cholinergic system in schizophrenia. The cholinergic system comprises the nerve cells or fibers that employ acetylcholine as their neurotransmitter. Chol...Aging alone does not affect brain system related to memory loss
... did this because darkness would thenstimulate the cholinergic system -- the brain system that involves memoryfun...orms ofdementia. In order to further stimulate the cholinergic system, rats alsoreceived a drug to allow this system to react more readily to stimulation. To measu......colleagues, in the abstract. Tacrine is a cholinergic agent that promotes acetylcholine transmissionin the brain. It is currently approved for the management of selected memorydisorders but not for Tourette syndrome. In contrast to Tacrine, drugs that blockacetylcholine transmission can aggravate tic ......ht to be linked to the loss of nerve cells, called cholinergic neurons, in the septal region of the basal forebrain. The delivery problem, says Saltzman, is that NGF "has a short half life of the order of minutes in the blood, and very little of a dose, perhaps less than 0.1 percent, reaches the brain, and th...