Researchers Identify Candidate Immunosuppressant With Fewer Side Effects
...us system damage, making them unsuitable for wider clinical application.The newly identified peptide prevents a single, specific step in the immunesystem's signaling pathway, so researchers anticipate that it will not causeserious side effects. Anjana Rao, professor of pathology, Patrick Hogan, invest...UB Plants "Seeds" By Investing In Research Projects; Researchers Leverage Investment 14 Times Over
...te professor of physiology, and Thomas Lock, M.D., clinical assistant professor of pediatrics at UB and Children's Hospital of Buffalo, from the National Institute for Neurological Disease and Stroke and a $60,000 grant from the McDonnell-Pew Program in Cognitive Neuroscience to develop an animal model of att...Identification Of Brain Areas Could Help Eliminate Side Effects Of Pain Medication
...-like drugs still comprise the major tool for the clinical management of pain even though the drugs can have some very serious side effects," explains Ralph Lydic, Ph.D., professor of anesthesia. "This discovery means we have specifically targeted an area in the brain and a molecule that causes side effec...Area of Research Outlined For Promising New Cancer Drugs
...he National Cancer Institute and will be rushed to clinical trialin humans. Castellino is very excited...ions to unreasonablelevels prior to the results of clinical trials. However, on the other side, thepotential beauty of these drugs is that they may only be req...Cost-Effective Treatment Possible In Africa For HIV-Positive Pregnant Women If Drug Prices Lowered
...The regimenscurrently are part of UNAIDS-sponsored clinical trials in Africa that aredirected at determining e...ealth policy andepidemiology, and Joseph Saba, MD, clinical research specialist, UNAIDS. It is estimated that about 6 million women in Sub-Saharan Africa-- whic...Earliest Warning Sign Indicates Need To Test For Condition Associated With Fetal Deaths
...or the presence of at least three of several known clinical signs of chorioamnionitis before ordering a test f...mending that the presence of only one of the known clinical signs is sufficient reason to conduct a diagnostic test for the condition, which they found present ...Scientists Create Extremely Sensitive Test For Detecting Radiation Damage
...y relevant damage fromionizing radiation even in a clinical situation," said Dr. Steven A. Leadon,professor of...re - fourhours before exposing the same cells to a clinical dose of two Gray, eight timesas much. Their assay showed pre-treated cells removed genetic damage ca...LOS ANGELES -- Results of a large-scale clinical trial, reported today by a UCSan Francisco researc...ents with advanced prostate cancer. The phase III clinical trial, designed to test the drug's efficacy, involved 458patients, with an average age of 68, at 76 ...New Drug Prevents Breast Cancer In Postmenopausal Women, UCSF Researchers Report
...n in other tissues, such as thebones. "During the clinical trials of raloxifene, we saw twice as many cases o...e added that the women who areparticipating in the clinical trials are making enormous contributions to thefight against breast cancer. "If we continue to see ...ONYX Pharmaceuticals Reports Phase II Clinical Trial Results At ASCO Meeting
...rent disease,notedDavid H. Kirn, M.D., director of clinical research at Onyx. "We have seen significant tumo...l complement of data and determine the nextstep in clinical development of ONYX-015. Depending on the outcomeof current and future clinical studies, it could be...First Patients Enrolled In NIH Clinical Trial On Effects Of Marijuana In HIV Patients
A clinical trial on the effects of marijuana in patients with...research unit designed to treat patientswho are in clinical studies requiring skilled medical and nursing care,monitoring, and control. In addition to studying ...New Treatment Targets Most Malignant Brain Tumors
DURHAM, N.C. -- In initial clinical trials, Duke University Medical Centerresearchers ...rapy." Although the newly reported Phase I clinical trial aimed only atestablishing the maximum tolerated dosage for the treatment, the researchersfound......d cortisol levels. These results indicate that the clinical relevance of antidepressants is thedown-regulation...symptoms of depression and anxiety inpatients. The clinical use of CRH-antagonists could therefore lead to a fasterand more effective therapeutic response than ......om three European,double-blind, placebo-controlled clinical trials lasting 12 weeks. Duringdouble-blind treatment, patients received 25 mg, 50 mg, or 100 mg of eithersildenafil or placebo. The investigators measured efficacy by utilizing theInternational Index of Erectile Function, an event log of erectile...Nitrosamines Play Important Role In Cancer Linked To Smoking
... Many agents havebeen tested in mice, and phase I clinical trials for the leading candidate, anisothiocyanate called PEITC, are being initiated. # # # # Researcher contact: Dr. Stephen S. Hecht, 612-624-7604 (phone); 612-626-5135(fax); hecht002@gold.tc.umn.edu (email); or Coleen Southwell, Directo...Brain Tumor Treatment In Multicenter Tests
...tients. Results of this multi-center phase-I clinical trial may have implicationsfor treatment aimed at ... The UNC-CH researcher is optimistic about the clinical trial, which willinvolve patients whose brain tumors have arisen from a variety of cancers.Evidence ......emiology findings inJanuary 1998, and in vivo and clinical studies in April 1998. The working group writing the advisory report will meet in publicsessions June 16-24 to discuss the research that has been done and vote, on thelast day, on what it indicates. The meeting will be at the Northland Inn,...New Study Designed To Improve Outcomes In Women With Metastatic Breast Cancer
...Center recently announced the beginning of a novel clinical trialdesigned to improve the outcome of metastatic breast cancer in some women. Themost frequently diagnosed non-skin cancer among women in the United States,breast cancer was expected to kill more than 40,000 women in 1997. Decades of research with......frequently. The findings of the phase III clinical trial appear in the June 18 issueof the New England Journal of Medicine. The research was funded in part by theDuke Comprehensive Cancer Center. "The improvement for these patients was significant enough that this nowconstitutes our standard...Intervention can help reduce risky sexual behavior, according to results published in Science
...ts were backed-up by a review of the participants' clinical records, which showed that those who attended the ...We think the study's full-year follow-up, with the clinical charts asan objective measure to back up the self-reports, is indicative that theparticipants' behav...