First head-to-head study to compare lidoderm patch and Celebrex in treating pain
...at 30% or greater reductions in pain intensity are clinically meaningful to pain patients). In the Celebrex gro...ent in average daily pain intensity. In addition, clinically meaningful reductions in pain were noted in both treatment groups at week 12. "Although these resu...Study shows patch therapy may be as effective as oral medications
... greater reduction in pain intensity is considered clinically meaningful to pain patients. "These findings ar...l, active-control, parallel-group study found that clinically meaningful reductions in pain were noted in the lidocaine patch 5% and the celecoxib groups at week ...Chronic pain treatments more effective when taken together, new study shows
... dosage a person can tolerate. "What we need to do clinically is to achieve a balance between side effects and pain relief," says the Queen's anesthesiologist. "The purpose of this study was to evaluate two different drugs for chronic pain, and to carefully measure both the pain-relieving effects and the side e......vestigate if patients with those diseases show any clinically relevant changes in the pharmacokinetics of different statins at various doses. Finally, the author suggests a reexamination of the product labeling on statins, which currently calls for monitoring of liver biochemistries before and during usage. "I...Hepatitis C and health-related quality of life
...lity-of-life effects. They established a minimally clinically important HRQOL difference (also called the "MCID"...rrhosis, the vast majority of people never exhibit clinically significant liver disease. Still evolving data suggests that HCV can diminish quality-of-life even w...ESC releases the first European Guidelines on Percutaneous Coronary Interventions (PCI)
...imary PCI over thrombolysis seems to be especially clinically relevant, for the time interval between 3 and 12 hours after onset of chest pain or other symptoms, on the basis of its superior preservation of myocardium. Furthermore, with increasing time to presentation, major-adverse-cardiac-event rates increas...Success of liver transplantation may be most influenced by three risk factors
...irm our model in the UNOS database and formulate a clinically relevant pretransplant model by using easily accessible variables that will accurately predict postransplant and patient survival. Such a model could be used to make recipient-specific organ allocation decisions at the time of graft procurement."...Other highlights in the March 16 JNCI
... diagnosed with prostate cancer, most of which was clinically localized cancer. Contact: Gwen Ericson, Washington University, 314-286-0141, ericsong@wustl.edu Also in the March 16 JNCI: Risk of Cardiac Death After Radiotherapy for Breast Cancer Has Declined, Study Finds: http://www.eurekalert.org/emb_rel...Rasagiline reduces disability for patients with advanced Parkinson's disease
...provide partial improvement, leaving patients with clinically significant off-periods, while adding complexity to the treatment schedule. Preliminary data shows that the additional use of rasagiline may be useful in the treatment of advanced Parkinson's disease. Olivier Rascol (University Hospital, Toulouse, Fr...Breakthrough in medical research: New chemotherapy gives hope to brain tumour patients
...Canada. "This study also identified MGMT the first clinically relevant molecular marker for glioblastoma which not only serves as a prognositic factor for survival, but also as a predictor for response to chemotherapy. This observation paves the way for using the unique tumor genetic signature as a guide for in...News tips from the 2005, 54th Annual Scientific Sessions of the American College of Cardiology
...logist and a radiologist, and using MRIs only when clinically necessary and when alternative diagnostic tests ar...t recommended. Evaluation of a safety protocol for clinically indicated magnetic resonance imaging of patients with permanent pacemakers and implantable defibrill...Pet scanning better for heart disease diagnosis, management
...the researchers calculated. PET currently is used clinically primarily for cancer patients. A Web site advocating the use of PET scanning in clinical cardiology lists only 25 sites in the U.S. that perform coronary PET scanning, two of which are in Western New York. Because little peer-reviewed literature ex...College students at no greater risk of alcohol-related problems than peers
...eports--although college students suffer from some clinically significant consequences of their heavy/binge drinking, they do not appear to be at greater risk than their non-college attending peers for the more pervasive syndrome of problems that is characteristic of alcohol dependence," the authors write. (Arc...Depression predicts heart rhythm abnormalities in heart attack patients
...ated for depression, and those who are found to be clinically depressed should have their heart activity closely...sion," Smith said. "Of those patients deemed to be clinically depressed, 38 percent had at least one episode of ventricular tachycardia, compared to only 10 perce...'Artery clearing' system does not provide benefit for patients undergoing PCI
...ery following a heart attack does not appear to be clinically beneficial, according to a study in the March 2 issue of JAMA. Dislodgement of atheromatous (an abnormal fatty deposit in an artery) and thrombotic (blood clot) material ("debris") during percutaneous coronary intervention (PCI) following a heart att...Genetic amplification (NAAT) test detects HIV more effectively than standard tests in urban study
... antibody tests or may be chronic carriers who are clinically asymptomatic. The NAAT test helps avoid these problems because it amplifies the HIV viral RNA and detects viral genes instead of viral antibodies or antigens. NAAT testing has been used in the U.S. as an investigational screening test for donated...No increase in C-sections when epidural analgesia given early in labor
... factors for cesarean section, Wong said. Another clinically important finding of the Northwestern study was that duration of the first stage of labor following epidural administration of analgesia was shorter by approximately 80 minutes. Previous studies have found that epidural analgesia compared to systemic...Most episodes of HIV 'blips' not clinically significant in patients receiving HAART
...ulation appear to be random variations rather than clinically significant elevations in viremia. Richard E. Nettles, M.D., from Johns Hopkins University School of Medicine, Baltimore, and colleagues investigated the nature and clinical significance of blips by assessing the HIV-1 RNA (ribonucleic acid) levels o...COX-2 inhibitors associated with blood pressure elevation
...he relative risk of developing hypertension and of clinically important blood pressure elevation in study partic...hors found. These blood pressure elevations may be clinically significant in relation to increased cardiovascular risk. The authors also saw differences between t...'Broken heart' syndrome: Real, potentially deadly but recovery quick
...etermined that cases of stress cardiomyopathy were clinically very different from a typical heart attack. "After observing several cases of 'broken heart' syndrome at Hopkins hospitals - most of them in middle-aged or elderly women - we realized that these patients had clinical features quite different from t...