130-year-old mysteries solved: how nitroglycerin works; why patients develop tolerance
...s down nitroglycerin takes place inmitochondria, a compartment within cells commonly known as the cell's "powerhouse." The enzymeis called mitochondrial aldehyde dehydrogenase (mALDH), and only in mitochondria can thenitric-oxide-related product of the enzyme get further processed to blood vessel-relaxingnitric ...Simple method to diagnose the abdominal compartment syndrome following trauma
...dominal region are at risk of developing abdominal compartment syndrome, a potentially life-threatening condition... to the authors. "It is the trend of the abdominal compartment pressure that is observed using this method, and detection of an upward trend in pressure can quickl...Study of deadliest form of stroke demostrates much lower mortality rates at high caseload hospitals
...achnoid Hemorrhage is defined as bleeding into the compartment around the brain. The most common cause of SAH is a ruptured brain aneurysm, which is a weak spot in a brain artery that has "ballooned" out. Other origins of hemorrhagic stroke are vascular malformations, high blood pressure that leads to the ruptu...Nicotine metabolite may improve memory, protect against disease
...wed a hypersensitive response and avoided the dark compartment longer than non-exposed mice. This response was identical to one the researchers had reported on previously (Journal of Neuroscience, May 2003) in genetically altered mice that lack high affinity nicotine receptors as a result of a knockout mutation...JCI Table of Contents, November 14, 2003
...us vector led to repopulation of the hematopoietic compartment with gene-corrected cells following suitable drug treatment. This selection system may be useful in human clinical trials of gene therapy in bone marrow transplantation settings. In an accompanying commentary, Arthur Bank from Columbia University Col......us base) critical for surfactant function into the compartment in the cell where surfactant is stored. "This kind of defective transport could lead to the production of abnormal surfactant, or, alternatively, a mutated ABCA3 gene could fail to transport out lipids toxic to surfactant function," he says. ...