Tag: "compound" at medical news
A marker for new blood vessel formation in tumors
...ine , Roland Haubner and colleagues describe how a compound
they have developed can be used together with high...veral drugs target angiogenesis specifically. The compound
previously developed by Haubner and colleagues is a fluorine-labeled glycopeptide, ([18F]Galacto-RGD...
Chemical decoy shows promise for slowing Alzheimer's by acting as decoy
... current drugs designed to treat Alzheimer's, this compound
attempts to target one of the underlying causes of the disease rather than just the symptoms. "Of course, there is a long way to go before one can use these molecules in the human body, but so far, in vitro studies look promising, not only from a t...
Benign separation process being advanced for pharmaceutical industry
...to synthesize the most ideal safe, pure, effective compound
or sub-compound into a drug. Despite the concern for safe processes, one of the most chemically benign separation processes has not been available to the drug industry. Now Virginia Tech researchers with support from Procter & Gamble Pharmaceuticals ...
Compound may help prevent diabetes in fast-food fans
...Although HPMC isn't likely to prevent obesity, the compound
may reduce the chances that obese people will deve... prevented development of insulin resistance." The compound
could actually make its way into food products as a functional food additive within one to two years...
Philanthropist Paul F. Glenn launches labs for aging research at Harvard Medical School
... team showed in a paper published in Nature that a compound
found in red wine called resveratrol could stimulate this pathway in yeast cells. The yeast cells lived as much as 60 percent longer, and in human cells tested in vitro, resveratrol activated a similar pathway. It enabled 30 percent of the treated ...
Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
...lgorithm that predicts the precise effects a given compound
will have on a cell's molecular components or chemical processes. Using this tool, drug developers can design compounds that will act on only desired gene and protein targets, eliciting therapeutic responses free of unwanted side effects. The rese...
Laughter helps blood vessels function better
...r, such as endorphins?" he asks. Dr. Miller says a compound
called nitric oxide is known to play a role in the dilation of the endothelium. "Perhaps mental stress leads to a breakdown in nitric oxide or inhibits a stimulus to produce nitric oxide that results in vasoconstriction," says Dr. Miller. The cu...
New substance that improves the photodetection of bladder cancer gains market approval
...ch into the development of a fluorescence-inducing compound
that may very well revolutionize the photodetection of superficial bladder cancer. This substance, hexaminolevulinate, is the active substance in a new pharmaceutical product that has been developed by the Norwegian company PhotoCure ASA. The new pro...
Plant derivative attacks the roots of leukemia
... will take months before a useable, pharmaceutical compound
can be made from parthenolide, the main component in Feverfew. However, UR stem cell expert Craig T. Jordan, Ph.D., and Monica L. Guzman, Ph.D., lead author on the Blood paper, say their group is collaborating with University of Kentucky chemists, wh...
Component of green tea protects injured livers in mice
...ellular injury were observed regardless of how the compound
was administered," the authors note. The authors conclude that "the data presented here indicates that EGCG protects the steatotic liver from I/R injury by reducing hepatic fat content, increasing energy stores, serving as an antioxidant and may stim...
Changing chemistry helps explain estrogen threat to the heart
... isn't made in an appreciable form. Now it makes a compound
called superoxide. It's an oxidant, and oxidation is bad in general. It causes a lot of cellular damage. But what we also have found is that now, instead of causing relaxation, it causes constriction. So you completely flip-flop the response here. "...
Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
...s known to reduce inflammation damage related to a compound
call peroxynitrite. They found that mice that received uric acid just before and right after an experimental spinal cord injury recovered motor function both faster and to a greater extent than mice that received only saline. Subsequent tests found t...
Promising treatments for Huntington's disease identified in UCI study
...gregation) and geldanamycin (a naturally occurring compound
found to relieve Parkinson's-like pathology). "These results provide a proof-of-principle approach to test combinations of compounds shown singly to have therapeutic efficacy in flies and in mammalian models of Huntington's disease," Thompson said. "...
Carrot component reduces cancer risk
...ts have given us another reason to eat carrots - a compound
found in the popular root vegetable has been found...s during storage. The scientists investigated the compound
after a previous published study suggested it could prevent the development of cancer. The research ...
Contrary to previous findings, smoking is detrimental to patients with Alzheimer's
... -- plaques and tangles -- as it is possible for a compound
to positively affect one lesion while worsening the other." Starting with mild memory problems and ending with severe brain damage, Alzheimer's usually begins after the age of 60, the risk increasing with age. If no effective therapies are developed,...
Effects of autism reach beyond language, new research suggests
...ned with each of the three given words, would make compound
words or a short phrase. For example, students wer...s experience prior to an exam the body releases a compound
called norepinephrine. Known as a "fight or flight" compound, norepinephrine allows the body to reac...
Pathogen-mimicking vaccine as strategy for cancer therapy
.... "What we're doing is testing a novel adjuvant, a compound
that stimulates the immunological response to a vaccine, which is essentially tricking the immune system into thinking the vaccine is a bacterial infection," says lead author Dr. Daniel Speiser from the LICR Lausanne Branch. "The immune system mounts...
New study finds kelp can reduce level of hormone related to breast cancer risk
...la. "Our next step is to try to isolate the active compound
in kelp that is having this hormone-modulating effect." She noted that seaweed contains several complex compounds, including polyphenols that are considered antioxidants. Kelp supplements are available in health food stores since they are taken as a ...
New leukemia drug shows promise in overriding all Gleevec resistance
...d adapting to Gleevec. "We developed ON012380, a compound
that specifically inhibits BCR-ABL by blocking a different site in the protein, which is essential for its activity. As a result, ON012380 was found to induce cell death of all of the known Gleevec-resistant mutants and cause regression of leukemias ...
USC/Norris oncologists test new front-line therapy for pancreatic cancer
...argets specific to cancer cells. In this case, the compound
aims to work in two ways: by directly inhibiting c...pts to keep cancer cells from proliferating. "This compound
also has anti-angiogenic activity," says Lenz. Angiogenesis is a process by which growing tumors rec...
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