LRRK2 gene mutation causes Parkinson's disease in several families
... research point of view, this is the first time we could identify what appears to be typical Parkinson's disease cases before people develop symptoms," Farrer says. "We know if someone inherits the mutation they are going to get Parkinson's disease." Farrer and his colleagues are beginning to explore the ...How links with tobacco industry may have influenced the publication of research on second-hand smoke
...co smoke 40 of them (61%) reached conclusions that could be judged to be industry-positive. Of these, 90% had at least one author with a history of an association with the tobacco industry. Professor Chapman concludes: "On the basis of evidence presented in this paper, there is a serious concern that the ...Study documents initial differences in sexual transmission of HIV between males and females
...ment of a vaccine or other preventive methods that could stop sexual transmission of HIV-1. The couples in the study come from the Rakai Cohort, a Uganda-based population in a long-term study of HIV infection. The researchers tested each couple's viral RNA to determine which variants, or kinds of HIV-1 ...Major review of subway systems suggests potential for significant health and safety hazards
...shon, "the risk of infectious disease transmission could be minimized through adequate maintenance of ventilation systems, frequent sanitation, and periodic disinfection of subway surfaces. At the individual rider level- prevention may be as simple as hand washing after riding the subways," she states. An...Study examines harm reduction among injection drug users
... other diseases. Improperly discarded used needles could pose a similar risk to the entire community. The study is among the first to examine safe syringe acquisition and disposal among new, young injection drug users. The results are published in the February 2005 edition of the Journal of Drug Issues. Th...Don't let your spouse become your caregiver
...r spouses may be more inclined to act in ways that could harm the impaired partner. The study, published in the Journal of the American Geriatrics Society , found that potentially harmful caregiver behavior was more likely in spouse caregiving situations. Clinical depression was also seen as a factor. "D...Columbia study finds hemophilia therapy dramatically improves outcomes for bleeding stroke
...rmine if recombinant activated factor VII (rFVIIa) could reduce hematoma growth after ICH. The primary outcome measure was the percent change in ICH volume at 24 hours. Clinical outcomes were assessed at 90 days. Key findings include: After dosing, the size of bleeding in the brain was assessed via CT...CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
...that while CK2 usually is continually active, they could block this activity using a CK2-inhibitor called DRB. Subsequently, the team showed that blocking CK2 with DRB made the cells very sensitive to TRAIL, causing them to commit suicide. This proved the important role CK2 played in preventing TRAIL-indu...Protein that promotes survival of stem cells might be key to poor leukemia prognosis
...netically modified mice so that the gene for Mcl-1 could be specifically deleted from the genome of HSCs and progenitor cells. Upon genetic deletion, these mice developed anemia and had severely reduced numbers of bone marrow (BM) cells, such as HSCs and progenitor cells. This was strong evidence that Mcl-...Schepens scientists regenerate optic nerve for the first time
...n and met with dozens of service men and women who could benefit directly from the good work of the people ...th the younger mice within only a few days. "We could see that at least 40 percent of the optic nerve had been restored," says Chen, "but we believe that ...OHSU scientists develop MRI approach to improve breast cancer detection
...is required, we believe shutter speed analyzed MRI could become a powerful tool for the diagnosis and treatment of breast cancer and almost any other form of cancer, as well as many other pathologies," explained Springer. "The shutter speed is a very general concept and applies to a great many different MR...Researchers model brain's electrical storm during a seizure
...ock market, weather, or other complex systems that could be affected by random events. They simulated the ... a computer simulation of a brain during a seizure could potentially provide a fuller picture of how and why electrical signals misfire. "This model could p...UCLA study shows that people drink less alcohol as they age
... particular medication," she said. One theory that could explain the disparity in drinking patterns between... age, they are more likely to have conditions that could be worsened by alcohol use (such as gastroesophageal reflux disease, depression or insomnia), and to...Potential drug target for treating cocaine abuse found
...ease blocks the stimulating effects of cocaine and could potentially be used to develop drug therapy for cocaine abuse, new research shows. In an article published in the February 23, 2005, issue of The Journal of Neuroscience, Jonathan Katz and his colleagues at the National Institute on Drug Abuse (NIDA)...New device will help stroke victims' recovery
...sing their expertise to help create a device which could greatly increase the rate of recovery for stroke victims. The device, known as Alladin, will diagnose the precise state of a victim from the time of the attack throughout their recovery, enabling medical staff to determine the correct treatment at ea...High-intensity ultrasound creates hollow nanospheres and nanocrystals
...and the first hollow nanocrystals. The nanospheres could be used in microelectronics, drug delivery and as ...llow nanospheres crafted from molybdenum disulfide could serve as a superior catalyst for removing sulfur-containing compounds from gasoline and other fossil...Researcher explores ways to make hypnosis a more effective therapeutic technique
...rong hypnotic response. "If we had scales where we could pre-select people who tend to be mindful, and cont...veryday life tend to not be especially mindful, we could see whether, for example, there were differences in the way they responded to hypnotic suggestions,"...Mayo Clinic researcher calls for improved newborn screening
...f the latest technology and double-tiered analysis could improve genetic screening for newborns as much as ...edictive value. He argued that better performance could be achieved by the addition of second-tier analyses. These are biochemical and/or molecular confirm...Diagnosis of prions in patients should utilize novel strategy, team says
...ensitivity of the CDI suggests that CDI-like tests could also prove useful for diagnosing other neurodegene...neurodegenerative diseases is unknown, but the CDI could shed light on these diseases," says co-author Bruce Miller, MD, UCSF A.W. and Mary Margaret Clausen ......is assuming that additional health-care facilities could be made available to distribute drugs. They conclude that in order to achieve the greatest degree of treatment equality, all 54 health-care facilities should be used, and they should, on average, each serve the population within a radius of 50 km. ...