Jefferson scientists find way to see breast cancer activity from outside the body
... the Journal of Nuclear Medicine. The gene, called cyclin D1, is turned on in the majority of breast cancers...arries an attached radioactive label, and binds to cyclin D1 messenger RNA (mRNA). The latter is involved in translating DNA instructions and making proteins....Hopkins' young researchers honored for their contributions
...inds to and degrades a cell cycle regulator called cyclin E. The findings, published in the March issue of N...ecome cancerous in 10 to 20 years. "We found that cyclin E levels rise in colon cancer cell lines with inactivated hCDC4 because the mutated hCDC4 protein ca...Cancer markers news backgrounder: Future of cancer diagnosis, treatment lies in tumor 'barcode'
...s found those with high levels of a protein called cyclin E were significantly more likely to have an aggres...working on methods to prevent generation of excess cyclin E as a way to prevent a cancer from becoming aggressive. "My hope is that this technique may help ea...Altered cyclin E protein leads to genetic instability in breast cancer
...nts who have high levels of "low molecular weight" cyclin E in their tumors. "We want to come up with a better mode of therapy for patients with this form of cyclin E and this model system may provide a biological tool for drug targeting," says the study's lead res...Other highlights of the May 21 JNCI
...heir colleagues found that LPA treatment increases cyclin D1 protein levels in ovarian cancer cells but not in normal ovarian cells. Cyclin D1 is a key cell cycle regulator that is overexpressed in various human cancers, including ovarian cancer. A previous study found that LPA can stimulate ovarian cancer ...Molecular tag pinpoints which breast cancer tumors are most likely to spread
...l of Medicine that high levels of a protein called cyclin E are closely associated with aggressive, invasive...ormer breast cancer patients, appears to show that cyclin E is a much better predictor of patient outcome than any current predictive marker. However, says K...Myc's cancer-causing joy ride more reckless than previously believed
...d's team showed that myc controls another protein, cyclin D, known toplay a big role in making cells grow; t...timescientists have identified the "brains" behind cyclin D's actions. Land's teamalso found that cyclin D can not only accelerate growth, which has been know...