Research in yeast yields missing link in DNA maintenance machinery
...king properly, damaged DNA can go unrepaired. Such damage can lead to unstable cells and eventually to cance...ng, the yeast becomes prone to the kind of serious damage to its genetic material that can lead to cancer in people. "The INO80 complex is found in organisms...Brain region identified that controls collecting behavior
...rol collecting behavior. The findings suggest that damage to the right mesial prefrontal cortex causes abnor...focal brain lesions - very specific areas of brain damage to see if damage to particular brain regions could account for abnormal collecting behavior. Other ...Researchers describe how human blood stem cells transform themselves to repair injured animal hearts
...at use bone marrow stem cells in people with heart damage have shown promise, but no one knows how it works. This starts to provide an explanation." Yeh and his research team, which includes investigators from the Texas Heart Institute, have been looking for a relatively simple way to help restore the func...Harlem Hospital Center, Columbia affiliate, recognized for efforts to fight glaucoma
...unities. Glaucoma is a group of diseases that can damage the eye's optic nerve and result in vision loss and blindness, especially when left untreated. The grant will fund screenings through September 30, 2005. "Glaucoma and diabetes are real problems among African Americans," said R. Linsy Farris, M.D.,...To help your mind, take steps to help your heart, study says
...like high blood pressure and high cholesterol does damage to small blood vessels in the brain and can cause ... areas of brain tissue, or through the build-up of damage from multiple small strokes cased by athero-sclerosis in small arteries in the brain or the larger c...First blood test to diagnose paralyzing, blinding disease
...d corticosteroids can be effective in stopping the damage and restoring nerve function. It's not clear how many people have NMO, though it's generally regarded as rare in the United States. However, one Mayo Clinic physician in Rochester has seen approximately 50 cases in the last three years, and an equal...Kinder, gentler procedure gives superior results for stem cell transplants
...y" protocol, in pediatric patients it may minimize damage to sensitive growing tissues like the brain and re...hat were later successfully withdrawn. To minimize damage to still-growing tissues such as the brain and reproductive organs in pediatric patients, the protoc...Brain imaging reveals new language circuits
...rl Wernicke, 19th Century neurologists, noted that damage to specific cortical areas, which came to bear the...found to connect Broca's and Wernicke's areas, and damage to this pathway also produced language disorders, or aphasias. However, even in the 19th Century, th...Surprise mechanism behind light-induced blindness
...sual impairment. The basis for this light-induced damage has remained poorly understood, but this week researchers report findings that run counter to the anticipated connection between light-induced retinal degeneration and accompanying blindness. To characterize the mechanism of photoxicity due to co...Cumulative trauma in adulthood can worsen health in later years
...umas experienced in childhood appear to cause more damage to an older person's (65 and older) health, say researchers of a new study reported on in the December issue of Psychology and Aging published by the American Psychological Association (APA). Traumas are distinguished from other types of stressful li...New data sets survival benchmark for Pfizer's ELLENCE
...nts experienced serious side effects such as heart damage or neutropenia. The most frequent toxicities repo...uth sores and hair loss. Because chemotherapy can damage the blood-producing cells of the bone marrow, patients may experience low blood cell counts. Some p...Hypertension: On the Pill? Tell your dentist
...ure before complications occur." Studies show that damage to arteries--and the risk for heart attack and stroke--actually begin to rise at 115/75. Medical experts issued new blood pressure guidelines: If systolic (top) pressure is less than 120 and if diastolic (bottom) pressure is less than 80, you are nor...Chemical cousin of anti-anxiety drugs holds promise for psoriasis treatment
...tinoic acid), which is used to treat acne and skin damage due to sun exposure. "One of the problems with retinoic acid is that, while it's very effective, it can also cause effects similar to psoriasis, so people often stop using it," Glick said. "Because the biological basis of retinoic acid hyperplasia (a...New study in NEJM suggests levodopa may slow progression of Parkinson's disease
...ncern that the medicine itself might cause further damage to the brain cells that are impaired in this disease. To resolve the controversy, a Columbia University scientist led a team of experts from the Parkinson Study Group to study levodopa's effect on the rate of progression of the disease. The study, r...Child health must become UNICEF's priority over next decade
...lead UNICEF. This discredited process threatens to damage the integrity of the UN system and, more importantly, it may well prove disastrous for the future of child health". In June 2003 THE LANCET published a series of articles which highlighted the shocking reality of global child health. The series sough...Protein 'key' could aid search for cancer drugs
... cells from making copies of DNA until the genetic damage is repaired. Shamoo and Bruning solved the structure of PCNA containing two other forms of PIP-box keys, both of which are involved in DNA replication. By comparing the chemical structure of the weaker keys against the stronger p21 key, they w...NHLBI stops sickle cell anemia transfusion study
...molecules in their red blood cells. The molecules damage the red cells, causing them to stick to blood vessel walls. This can lead to narrowed, or blocked, blood vessels in the brain, causing a stroke. The participating centers in STOP II were: Children's Hospital Medical Center; Cincinnati, OH; Children'...Ongoing transfusions needed to avoid strokes in children with sickle cell disease
... Adams says. The difference could be proteins that damage blood vessel walls or enhance cells sticking to those walls, he says. "Although we have a very effective primary prevention strategy, we have not made substantial progress in understanding what is driving the process," so Dr. Adams also wants to stu...Two-fisted assault on dopamine transport system may be foundation of Parkinson's disease
...tive ability, however, allowing rotenone to do its damage unchecked. Feng and colleagues showed that rotenone damages the microtubules, which prevents dopamine from reaching the brain's movement center, causing a back-up in the dopamine transport system. Meanwhile, the backed-up dopamine acc...Nerve damage from alcoholism reversed after liver transplantation
Organ damage that goes beyond the liver due to alcoholism is of...isease complicated by peripheral neuropathy (nerve damage affecting the arms and legs) who underwent a liver transplant and regained almost normal muscle stre...