Bristol-Meyers Squibb submits NDA for new formulation of once daily videx(R)(didanosine)
...to provide adequate buffer to prevent gastric acid degradation of VIDEX. VIDEX tablets are the first and only once-daily nucleoside analogue reverse transcriptase inhibitor (NRTI), the class of drugs which form the foundation of anti-HIV therapy. VIDEX in combination with other antiretroviral agents is indicat...Pharmaceuticals and personal care products
... in Shreveport, La. The most common mechanisms for degradation and depletion of these drugs are hydrolysis, photolysis and biodegradation, he says. His talk will address these mechanisms and the "potential for decline of drug substance residues." These mechanisms, coupled with dilution from surface water and soi...Scientists declare global warming and human impacts are combining destructive forces on coral reefs
...he health of coral reefs and addressed the serious degradation that coral reefs are suffering at the hands of hum... and ideas for helping coral reef managers prevent degradation by more local forces such as blast and cyanide fishing. Surprising findings include the partial but ...Australian chemists present new research findings at Pacifichem 2000
...lease until date and time of presentation): Rubber degradation - Researchers at Monash University have found a wa...hnique - nuclear magnetic resonance - to determine degradation in rubber products, such as tires, seals and conveyor belts. The noninvasive technique allows people...New sensor upgrades artificial bomb sniffers
...conditioned not to need odor-recognition training, degradation and retraining problems could be eliminated, Walt and his associates say. Billions of the sensor beads can be made at once, as needed, whether daily, weekly or yearly, providing a continuous replacement stock, according to the researchers. To test ...Science backs Cod Liver Oil as cure for arthritis
... fatty acids in Cod Liver Oil can reduce cartilage degradation and inflammation in arthritic disease. Our most recent work shows that by exposing human osteoarthritic cartilage to Cod Liver Oil in the laboratory for just 24 hours we can turn off, or reverse, the action of the degradative enzymes and inflammator...Post-genomic technique provides real-time, multiscale look at protein life cycles in living cells
...ifferent, time-separated stages of development and degradation of the protein. In addition, the fluorescent proteins are often larger than many of the proteins they are attached to. And, they dont allow researchers to explore the dynamics of the protein at different resolution levels, from the larger cellular ...Pain may come with gain in childhood exercise
...bad signals are catabolic. They actually encourage degradation of cells and are commonly linked to diseases. The mystery we need to solve is how much exercise is too much, and how much of these changes in signal levels are a normal product of development." Cooper's team reported in the Pediatrics study that afte...Exploring the relationship between alcoholism and serotonin one step at a time
...uction of serotonin, the factors that regulate the degradation and the reuptake of serotonin, as well as the activity and number of receptors that respond to serotonin. So this means a complex system. "What we wanted to do for this study was use a very specific probe of the serotonin system, a functional prob...Improved molecular beacons show promise for cancer detection, rapid viral diagnosis
...nificantly reduce signal contamination from beacon degradation and spontaneous opening." In addition to these innovations, as part of studies to optimize the beacons, researchers have learned how molecular beacon design and other factors affect binding time, specificity and accuracy. Optical signals can be measu...UCSD researchers determine mechanism for degradation of G proteins
...ein N terminus (GIPN) that plays a key role in the degradation of G proteins, which are switches that turn activi...GIPN appears to specifically target G proteins for degradation and thereby regulates G protein signaling by controlling the amount of G protein expressed in the ce...Nanoneurosurgery, search for E-T life, bioscan technology and home holograms at frontiers of optics
...roach provides several advantages such as graceful degradation (part of the face can be occluded and it is still recognized), shift-invariance (images do not have to be centered) and smaller error rates. Bhagavatula will show results in which a filter trained on just three views of a person's face could successf...New ultrafast MRI benefits stroke patients
...n a shorter period of time are less susceptible to degradation from the patient moving during the scan." Dr. Gillard is a lecturer and honorary consultant neuroradiologist at Addenbrooke's Hospital, University of Cambridge in England, where the study is ongoing. To be successful, treatment with intravenous thro...Cancers' love-hate relationship with proteins offers new treatment window
...omerase normally contributes to the repair of this degradation and the mending of other genetic instability. To get a more detailed sense of how vulnerable the cells had become, Pandita's team exposed them to radiation and to heat followed by radiation. In test tube studies and in the genetically engineered ...Doctors at Northwestern Memorial are studying next generation surgery for back pain sufferers
...ly two moving parts. We expect this will decrease degradation of the disc and reduce problems with the mechanics of the disc." Fusion, the current standard of care, is performed more than 200,000 times in the United States each year. "The reason we're looking for alternatives to fusion is that, while fusing two...Vitamins good for some older women/bad for others
...n C into "pro-oxidants" that actually increase the degradation of good cholesterol. The combination of high iron and high blood sugar levels boosts oxidation in a similar way. This additional problem might help explain why vitamin therapy produces such significant setbacks in diabetic patients with atheroscleros...UCSD researchers determine fibrin depletion decreases multiple sclerosis symptoms
...ice showed fibrin accumulation, inflammation and a degradation of the myelin in their spinal cord. When transgenic mice were bred without fibrin, they developed a later onset of the MS-like paralysis as compared to their transgenic brothers that had fibrin. In addition, the fibrin-depleted mice lived for one ad...Is there a relationship between repeated pregnancies and increased cardiovascular disease?
...rted that repeated pregnancies are associated with degradation of vascular elastic tissue and an increase in the incidence of spontaneous arteriosclerosis of the aorta, and of the mesenteric and renal vascular beds. It has also been reported that repeated pregnancies attenuate the production of nitric oxide in t...