PRAECIS PHARMACEUTICALS INC receives FDA approval for Plenaxis
... were directly related to study drugs, to androgen deprivation therapy, or to other variables. Because Plenaxis TM may prolong the QT interval, physicians should carefully consider whether the risks of Plenaxis TM outweigh the benefits in patients with baseline QTc values greater than 450 msec (e.g. congenita...Experimental drugs reduce neuron death in rats following insulin shock
...eceived the drug one hour after the end of glucose deprivation experienced about 70 percent reduction in cell dam...RP inhibitors three hours after the end of glucose deprivation experienced minimal reductions in cell damage. Six weeks after these tests, rats that had been immed...Hormones increase side effects, complicate treatment decision for prostate cancer patients
... effects. "The use of short and long-term androgen deprivation appears to significantly increase the risk of moderate to severe GU and GI side effects, but we know that hormone therapy can extend the lives of men with advanced disease," Feigenberg concluded. "These results make the balance of survival versus qu...Dose of radiation therapy directed to the prostate affects treatment outcome
...idered to be more than 70 Gy. Short-term androgen deprivation was not an independent predictor for cancer control.Other study authors include Alexandra L. Hanlon, Ph.D., Eric M. Horwitz, M.D., Benjamin Movsas, M.D., Robert Uzzo, M.D., and Alan Pollack, M.D., Ph.D., of Fox Chase Cancer Center.......e to control the effect of estrogenic presence and deprivation more effectively. "We want to play a major role in development of these new agents," says Cristofanilli. "If our trial with Iressa is positive, it could change the way we treat breast cancer." Testing Iressa in prostate cancer Prostate cancer ...New evidence eases some concerns about bone fracture risk with breast cancer drug
...ff this hormone. But, one consequence of oestrogen deprivation is that bones become vulnerable. Aromatase inhibit...ors such as anastrozole produce profound oestrogen deprivation so it would not be unexpected that women on anastrozole might be more at risk of fractures than thos...Study links IQ and affluence level to longevity
... "The significant interaction found between IQ and deprivation suggests that IQ in childhood is less important in...n, they then categorized the subjects according to deprivation and social class. Finally, they used health and hospital records to determine the causes and dates o...High percentage of N.C. children suffer undiagnosed asthma, new study shows
...g-term clinical implications include chronic sleep deprivation and the related reduced immune function, increased susceptibility to respiratory infections, reduced cognitive function and decreased learning ability," Yeatts said. Of the 11 percent of children surveyed whose asthma already was diagnosed by a physi...An extra hour of sleep can make a big difference for kids
.... Previous studies of adults have found that sleep deprivation significantly impairs the brains executive control system, which helps people organize, prioritize and focus on tasks. But few sleep-deprivation studies have focused on children, and those few have tended to examine extreme rather than modest sleep d...Epilepsy linked to social deprivation
...t deprived fifth. This suggests that socioeconomic deprivation is an important risk factor for the development of epilepsy, although the results may partly reflect differences in the incidence of epilepsy within and outside London, say the authors. It is not clear why low socioeconomic status might increase risk......a sleep debt that will ultimately harm them. Sleep deprivation leads to cognitive impairment, as well as seriously disrupting the immune and hormone systems, although it is not known how long these effects last. And Paul Blake of Cephalon acknowledges Provigil's limitations: "The drug isn't a replacement for sle...Children in deprived areas three times more likely to be hit by a car
...ts for children, examines the relationship between deprivation and child pedestrian casualties in Britain and the...nd the volume of road space. We didn't know if the deprivation effect would stand up having controlled for these effects - but it does and it is very strong."...Fred Hutchinson receives $12.7 million to lead prostate-cancer consortium
...f life, it is not considered curative, as androgen deprivation is only effective in controlling the growth of the cancer cells that feed on male hormones. Eventually, these hormone-sensitive cells are crowded out by hormone-insensitive cancer cells, which don't depend on male hormones to proliferate.Improving th...Should people with diabetes sleep with the lights on?
...diabetic retinopathy) might be initiated by oxygen deprivation to the inner layers of the retina during the hours of darkness; this is thought to occur because the rod receptors (responsible for night vision) have the highest oxygen demand of any cell in the human body at low levels of illumination. Analysis by ...Hungry children: more depression, suicide, low grades
... studies at Cornell University. "The level of food deprivation in this wealthy nation puts millions of children at risk for multiple developmental problems," says Katherine Alaimo, who obtained her Ph.D. at Cornell in 2000 and now is a community health scholar at the University of Michigan. Alaimo conducted the ......late on weekends may be a result of relative sleep deprivation during the week. Previous research has indicate...search has suggested that in this age group, sleep deprivation may play a role in lower grades and with behavioral problems. Changing school start times to later ...Study suggests insulin may have potential to prevent thrombosis leading to heart attack and stroke
...y to a variety of stimuli related to tissue oxygen deprivation and physical damage to blood vessels, Dandona said, and appears to play an important role in the development of human and mouse atherosclerosis. The protein TF leads, via a complex cascade of actions, to the formation of fibrin, the essential ingredi...Hormone therapy for breast cancer - the treatments of the future
...e that the differential effectiveness of oestrogen deprivation and tamoxifen was greater in tumours expressing the growth factors HER2 (up to a quarter of breast cancers) and/or EGFR (about 20% of breast cancers). "This means that we need to try to find a new generation of SERMs lacking this oestrogenic activity...Prostate cancer hormonal therapy may increase sexual and physical problems
...tage prostate cancer who are treated with androgen deprivation therapy (ADT) may experience more physical discomfort and be twice as likely to experience sexual impairment compared with men who forgo such therapy. In the March 20 issue of the Journal of the National Cancer Institute , Arnold L. Potosky, Ph.D.,...Hormone therapy for prostate cancer causes weight gain and increased body fat
... order to offset these adverse effects of androgen deprivation therapy, but ultimately the long-term solution will be to develop better drugs for prostate cancer patients. "We need to develop improved strategies to prevent these side effects," he explains. "Our research program is evaluating whether other drugs...