Tag: "derivative" at medical news
Progesterone therapy could prevent thousands of preterm births
...ature baby and eligible for weekly injections of a derivative
of the hormone progesterone had received them, acc...lth who participated in the analyses. The hormone derivative
is known as 17P, short for 17 alpha-hydroxyprogesterone caproate. "Two percent would be a modest red...
Chocolate ingredient could put a stop to persistent coughs and lead to new cough medicines
...urnal the team have discovered that theobromine, a derivative
found in cocoa, is nearly a third more effective in stopping persistent coughs when compared with codeine, currently considered the best cough medicine. Professor Peter Barnes, from Imperial College London and Royal Brompton Hospital, and one of the ...
Topiramate: a potential new medication for treating alcoholism
...nsmission, topiramate a sulfamate fructo-pyranose derivative
decreases dopamine release through antagonism of glutamate activity at alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainite receptors and facilitation of the inhibitory neurotransmitter, gamma amino butyric acid (GABA). Johnson c...
New compound may act to keep thyroid activity in check
...ound, 3-iodothyronamine T1 amine, for short is a derivative
of thyroxine, an essential thyroid hormone that influences development, body temperature, metabolic rate and cardiac performance, it has the opposite effect of thyroxine, according to a study by scientists at Oregon Health & Science University, the U...
Mayo researchers invent targeted imaging probe to aid early Alzheimer's diagnosis
...mists and peptide synthesis specialists designed a derivative
of the human amyloid-beta peptide (the molecule that contributes to plaque formation) to create a new kind of molecular probe. To test its targeting ability to find amyloid plaques in laboratory Alzheimer's disease mice, the researchers injected the ...
Solvent, common drug plus hormones raise risk of reproductive failures and breast cancers
...m found that EMGE is converted by the liver into a derivative
compound called methoxyacetic acid (MAA). Valproic acid is administered in an already active state. Once inside cells, MAA inhibits a class of enzymes (histone deacetylases) that normally slows the process of gene transcription, in which...
New weapon to combat resistant bacteria
...ed on the fact that the new substance is a peptide derivative
based on a larger protein called cystatin. Cystatin occurs in various forms in the body and is part of our natural protection against bacteria, fungi, and viruses. The Lund researchers Aftab Jasir and Claes Schaln, medical microbiology, and Anders ...
Northwestern Memorial enrolling participants in two trials on new drug to fight deadly cancer
...y, who is leading the trials at NMH. Revimid is a derivative
of thalidomide and belongs to a new class of drugs called IMiDs, or immunomodulatory drugs, which are drugs that modify or regulate the functioning of the immune system. IMiDs appear to have multiple actions, including the ability to stimulate the im...
GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003
...University of Pittsburgh. Mappicine is a natural derivative
of the plant Mappia Feotida. It is hoped that a mappicine analog will prevent HIV RNase H from degrading the RNA component of the RNA/DNA duplex intermediate, thereby preventing HIV replication. Similar chemical derivatives that inhibit topoisomera...
Epstein-Barr virus contributes to Burkitt's lymphoma
...ost 10 years ago, Sugden and his colleagues made a derivative
of EBNA-1, which inhibits the real protein. When the derivative
binds to its site on the EBV DNA, it prevents EBNA-1 from doing so, interrupting its functioning. In...
Antiepileptic drug developed at Hebrew University to undergo phase three clinical trials
...dent, Dr. Salim Hadad, worked to develop a glycine derivative
which would penetrate the blood-brain barrier and would subsequently be cleared out of the body by a pre-designed elimination pathway in order to avoid undesirable side effects which may be caused by toxic metabolic substances (metabolites). The n...
New study shows green algae extract boosts flu vaccine
...rise the first published human study showing how a derivative
of a food source algae improves the body's immune response to a commonly used vaccine for influenza. "Our clinical study clearly demonstrates Respondin has a biological effect in humans, increasing the antibody response to a flu vaccine in this popul...
UCB's pharma sector announces promising first results of a new antiepileptic drug candidate
...-controlled trials. Ucb 34714 is a new pyrrolidone derivative
from the same chemical family as levetiracetam. As such it builds on all the existing properties of levetiracetam whilst potentially providing improved efficacy due to its distinctive pharmacological properties. Estimates vary but it is estimated tha...
Dartmouth researcher Michael B. Sporn, M.D. honored for pioneering work in cancer prevention
... activities. The development of a potent new plant derivative
called CDDO is evidence of the success of this new approach, and indicative of the momentum Sporn maintains in chemopreventive research. According to Mark Israel, M.D., Director of Norris Cotton Cancer Center, that momentum also fuels the work of can...
Marijuana-derived compound targets pain, inflammation
...ry studies indicate that the compound, a synthetic derivative
of THC, is more potent than aspirin and ibuprofen,...otherapy. But this drug, which is also a synthetic derivative
of THC, has been reported to cause a "high" in some patients. "Some people want the high," admits Bu...
Fantastic Voyage -- Filled buckeyball now a step closer to becoming a drug-delivery device
...ent Erick B. Iezzi has developed the first organic derivative
of a metallofullerene. He has figured out how to m... (Sc3N@C80). That is, he attached an isochromanone derivative
to a buckeyball. "You heat the isochromanone until it loses carbon dioxide and attaches to the fulle...
New study of coated stent long-term results disappointing
...rience, they used a stent coated with QuaDS-QP2, a derivative
of paclitaxel, a drug that blocks cell growth. The study included 15 patients who had previous angioplasty and had developed new blockages. The average age was 59, and 13 of the patients were men. Patients blood vessels were examined at six months ...
Blood lactate measurement could lead to earlier identification of patients for liver transplant
...se of the measurement of arterial blood lactate (a derivative
of lactic acid) for the identification of transplantation patients. The investigators measured blood lactate concentrations early (at 4 hours) and after fluid resuscitation (at 12 hours) in patients admitted to an intensive-care unit. Threshold value...
Yale researchers create topical estrogen that alleviates sexual dysfunction in menopausal women and eliminates side effects of conventional estrogen
...the treatment of menopausal disorders." Using a derivative
of estradiol, the major estrogen, that, because of its charge, was no longer estrogenic, Hochberg and his team masked this group-derivative by another substitution, resulting in a compound that was highly estrogenic, meaning it could bind the estroge...
Tobacco chemical protects against Parkinson's disease
...Disease. The tobacco compound is described as a derivative
of naphthoquinone, and works by interfering with a...d severe Parkinsonian symptoms. The naphthoquinone derivative
protected the rodents against the toxic effects of MPTP, according to the researchers. The research...