Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
... In his new report for the ACS meeting, he will describe what he callsa novel application of the solvent isotope effect. Using a instrument known as a "microcalorimeter," Toone andhis students were able to measure temperature differences as small as amillionth of a degree as protein binding sites bou...Cancer Protection Compound Abundant In Broccoli Sprouts
...ionalAcademy ofSciences, Talalay and his coworkers describe their successful efforts to buildon their 1992discovery of sulforaphane's chemoprotective properties. Work described in thestudy is thesubject of issued and pending patents. A systematic search for dietary sources of compounds that increasere...'Bathtub' Equation Aids Diabetes Research
...tive, she developeda mathematical model that could describe how the cells were formed and howthey died. The model predicted a phase of cell death in young, normalgrowing rats. Further research proved the prediction to be true. "Just thinking about the numbers and using some basic principles allowed usto learn...X-ray Microscope Designed To Study Jet Engine Components Now Probes Tooth Dentin
...t, the UCSF researcherswere the among the first to describe why the polymer bonding process works bestwhen the dentin remains moist. In the bonding process the liquid fillingpenetrates moist dentin more easily than drier dentin -- much as a moist spongemore quickly absorbs water than a dried sponge, Sally Ma...Tighter Chemical Binding = Better Meds
...to improve their design -- work thatJorgensen will describe on March 31 at the ACS annual meeting. The Yalechemists also have analyzed drugs that regulate the protein thrombin,which is important for controlling blood clotting. Another application being explored in Jorgensen's laboratory isthe development of...How Reliable Are League Tables?
.... In this week's BMJ, Marshall and Spiegelhalter describe a new statistical technique that can be used to quantify the uncertainty about ranking. They have applied it to in vitro fertilisation clinics in the UK and found that the rankings were not entirely meaningful and therefore it would be unwise to tak......niversity ofWashington (and President of ASA) will describe experiments with high-intensityultrasound which show how one can significantly reduce the oozing and bleedingthat traditionally hinders liver surgery (2aBV3). Gail ter Haar of the RoyalMarsden Hospital in England (011-44-181-642-6011; gail@icr.ac.u...Injecting Drugs With Sound Waves
...s Greenleaf of the Mayo Clinic (507-284-8496) will describe howultrasound may aid the introduction of genetic ...f the University of Washington (206-543-6921) will describe thetechnique of ultrasound enhanced thrombolysis (UET)--the use of ultrasound todestroy blot clots e......isfactory. At the final visit, women were asked to describe the best and worst features ofthe method. The most commonly cited positive attributes were no surgery and/orinjections, noninvasive; natural, feminine, like menses or miscarriage; lesspain; easier emotionally, less frightening; and easier, simpler, ...Policy Methods For Eliminating Child Labor
...If there are any indications that the process they describe will not apply to a certain country, they recommend that no ban on child labor be imposed and that economic development efforts be targeted at the adult labor market. The researchers say that current political efforts to curb child labor are driven b...Penn State Chemist Identifies New Lime Aroma Component
...ndin lime oil and have the students sniff them and describe what they smell," sheexplains. "We then dilute the mixtures to find out whether the aroma changes." Chisholm, who received the 1998 Behrend Council of Fellows FacultyResearch Award, adds that the project is an excellent tool for educating and......e, 15 industry and academic experts Oct.22-23 will describe how combinatorial chemistry also is speeding the s...ence. To illustrateits remarkable promise, he will describe efforts to identify and refine avariety of luminescent materials and catalysts-compounds that increa...First Drug Shown Effective For Treating Chronic Forms Of Major Depression
... Journal of ClinicalPsychiatry, the articles describe rapid improvement in the psychological and social behaviors among 635 depressed patients treated with either sertraline orthe drug imipramine. From increased productivity at work to better social relationships, patients showed great...Discarded Treatment For Heart Attacks May Yet Prove To Be A Life-Saver
...te of theinjection. Phlebitis is the term used to describe the stiffness, inflammationor pain occurring when a vein is punctured. "If this reduction in heart attack death rates is confirmed in furtherstudies, GIK has the potential to prevent about 75,000 heart attack deaths peryear in the U.S.," says......oston, and his colleagues from Harvard University, describe the active structure of RT. In order to capture RT in an active form, Harrison knew that the enzyme needed to be constrained, so he approached Harvard chemists, Gregory Verdine and his postdoctoral fellow Hulfgang Huang, and asked them to tether RT t...Now Is Time To Design Brain-Saving Drugs Specifically For Children, UCSF Neurologist Says
...istopher Giza and Raman Sankar of UC - Los Angeles describe how the geneticunderpinnings of childhood epilepsies may lead to new, highly specifictreatments for seizures -- and also may show why some children develop epilepsyafter a brain injury, and others do not. --Nicola Robertson and A. David Edwards of ...Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
...to SERMs. In the Cell paper, the researchers describe how tamoxifenalters the normal shape of the receptor in a way that covers up a co-activatorbinding site that is ordinarily exposed by estrogen or by synthetic estrogenssuch as DES. Tamoxifen causes one region of the receptor to rotate out of place,no...Visual Environment Can Affect Even Healthy Eyes --- Nature Works With Nuture For Good Vision
...e retina because the eye is too short. These terms describe refractive error -- the degree to which you have normal,myopic or hyperopic vision. Refractive error is determined by two measures: the length of the eye and the power of the eye's optical system, which includes the curve of the cornea. When....... on Friday night. Drs. Weinberg and Chabner will describe current researchon the origins of cancer and explore how that knowledge is used as a basis forthe development of new cancer therapies. At the symposium for registered participants on Saturday, speakers will focus oncurrent therapies, clinical trials,...Brain Activity Differs In Introverts And Extroverts, UI Study Shows
...tions in brain function, but those studies did not describe all thelocations found in this study. The UI researchers examined 18 healthyindividuals using positron emission tomography (PET) scans, which can provide ahigh-resolution image of the entire head. The PET scans revealed that introverts have more act...