Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
... that gene therapy was safe, but that we needed to design a viral vector that would harness the power of the immune system to help eliminate the tumor," commented Dr. Castro. Genetically engineered viruses are used to transport genes and/or proteins into cells and have been used in gene therapy resear...Novel drugs help solve Gleevec resistance
...entially ineffective dose," says Giles, who helped design the protocol. "Everyone keeps moving up until we f...he bottom line, says Giles, is that "rational drug design is a reality and effective targeted therapies will rapidly increase in number, which means that opti...Establishing pediatric stroke trials
...e prior experience in trials with children trial design and pitfalls Faculty: Hosted by Steven Pavlakis, MD, Director of Pediatric Neurology, Maimonides Medical Center. Members of the International Child Stroke Study Group; Toronto Sick Childrens Hospital; University of California San Francisco; Chil...Obesity hinders imaging quality, diagnosis
...ment. "Manufacturers need to think about design changes and technological advancements to obtain quality imaging in larger patients," Dr. Uppot said. "In the meantime, radiologists need to be aware of the limitations of their current imaging equipment and optimize current protocols and equipment s...Stem cells of limited use for cardiac muscle repair
...tand the mechanism, she added, we might be able to design a more effective approach. The next step may be to find more flexible sources of injectable cells. Although readily available, BM-SP cells appear to have limited potential. Several researchers are trying to isolate a putative cardiac ste...Employment reduces chronic drug use, UH professors find
...resources." Montoya's next steps are to design drug prevention efforts for drug using welfare recipients that rely upon this "work therapy" model as its key component to prevent continued drug use. Future drug prevention research efforts also may benefit from observing how individuals spend thei...Canadian researchers to develop 'smart drug' to repair psychiatric disorders
...ng at the cellular level, the team will test their design of a type of drug that can fine-tune communication between brain cells and bring excitatory and inhibitory activity into a healthy balance. Existing anti-psychotic drugs adjust communication on cell surfaces throughout the brain. Balance is restored...University of Manchester uses crystals to help battle deadly diseases
...e structures therefore are incomplete making drug design more difficult. Professor John R. Helliwell, Professor of Structural Chemistry, who led the research, said: "This has raised the stakes in the world of drug discovery.This methodology will make research in the field more powerful, more effective and ...New Jersey Institute of Technology pioneers new way to teach engineers
In Professor Richard Foulds' freshman design class, students perform angioplasty on pasta, amni...neering. One recent afternoon in Foulds' freshman design class, students worked happily in teams, building surgical robots. Foulds darted from team to team, ...Proposed addiction treatment successful, safe in second small trial
... for a mean duration of 12 years. The experimental design was "open-label," that is, the subjects knew they were getting GVG, an experimental treatment for drug addiction. Of the 30 volunteers, 18 stayed in the study for the nine-week duration. Of those, 16 were methamphetamine- and cocaine-free...Rice engineers demo first T-ray endoscope
... lasers and coaxial cables for microwaves -- allow design flexibility because they move and direct energy where it's needed. This is particularly useful if the beam generator is bulky or temperamental. Both fiber optic cables and coaxial cables work by confining the energy of the beam in a small space, caus...All chronic sinusitis is not created equal, study finds
...be obtained from a simple blood test. "Then, as we design studies to look for still better treatments, we can use this information to compare apples to apples," says Dr. Kountakis....Panel offers recommendations for monitoring adverse events from dietary supplements
... FDA with an eye to making recommendations for the design and implementation of an effective monitoring system for adverse events relating to dietary supplements. Results In their Phase I review, the Committee found that the records collected by MET were qualitatively less informative than those collec...Proposed addiction treatment successful, safe in second small trial
... for a mean duration of 12 years. The experimental design was "open-label," that is, the subjects knew they were getting GVG, an experimental treatment for drug addiction. During the first two weeks, they were given increasing doses to a maximum of three grams per day, and then maintained on that dose for 2...Diabetes among older adults imposed an estimated $133.5 billion cost in 1990's
...This study makes excellent use of the longitudinal design of the HRS, one of the few studies that measures both health and economic factors in the same study, to demonstrate the huge negative economic impact that diabetes has on our society beyond the personal costs of illness and premature death," said Ric...Monitoring life, one breath at a time
...at the University of California, San Francisco, to design and test a field-ready medical device. The Nanomix researchers developed their nanotube transistor as part of NSF's Small Business Innovation Research program, and they are also applying the new technology to optoelectronic memory applications. The ...Cancer researchers seek to predict tumor growth
...rs. These centers will provide the nucleus for the design and validation of computational and mathematical cancer models. The models will simulate complex cancer processes, and will be used to address all stages of cancer, from the basic cellular processes through tumor growth and metastasis. "The key aspec...Rehabilitation professionals in nationwide survey cite barriers to assistive technology transfer
...ucts with mass appeal. Incorporate more universal design principles in research to broaden the application of new products and devices. Attract interest from manufacturers and venture capitalists by making assistive technology more commercially viable, and convince investors of the broader pool of technol...FDA buys technology that identifies drug toxicity to heart
...rs ago. To meet this standard, most companies that design Phase I and II clinical trials require thousands of volunteer subjects to undergo an extensive physical examination, which includes a review of a patient's 24-hour EKG. The patient's EKG data is loaded onto a computer. Doctors look for abnormalitie...$2.8 million public-private partnership to examine how surroundings can encourage active lifestyles
...unding agencies, will examine how better community design encourages people to be more physically active in ...e impact on physical activity and obesity of local design and transportation changes. The Robert Wood Johnson Foundation's Active Living by Design Program is ...