Blocking pathway overcomes tumor vessel resistance to radiation
...dothelial cells. In animals, these agents enhanced destruction of tumor blood vessels. Hallahan pointed out that this approach to cancer therapy, though based on the same notion that cutting off the tumor's supply lines will defeat the tumor, is different from the field of anti-angiogenesis that has received so...New procedure kills liver tumors without surgery
...he tip of the probe, we can generally limit tissue destruction to the region of the tumor without damaging the surrounding tissue." After the heating session, the needles are slowly withdrawn at a slightly lower temperature in order to cauterize the wound and minimize bleeding. All the patient needs is a small ...First trial of endostatin shows biological activity
...s no relationship between dose of the drug and the destruction it caused, and may indicate that endostatin has a delayed onset of activity, says Herbst. "This study is the first to suggest that endostatin can induce endothelial cell apoptosis and changes in tumor flow in some patients with advanced cancer," he ...No extra disease seen in chemical-exposed Gulf War veterans
...by U.S. facilities that will shortly engage in the destruction of aging munitions containing the same chemical agents that were destroyed at Khamisiyah. The release of small amounts of CW agents from the incinerators are not likely to cause illness in those who live nearby....New avenue of HIV damage found
...th therapy. The researchers suggest the process of destruction is analogous to what is seen in chronic active hepatitis. "We knew that T cells are destroyed by direct viral replication," said Schacker, "but we now know that the population is unable to recover to a normal size because the environmental niche use...Bacterial protein kills tumors
...r severe burns. The bacterium protects itself from destruction by killing macrophages, the immune system's first line of attack against a foreign body. In the UIC study, specially-bred immunodeficient mice implanted with human melanoma were treated with half a milligram of azurin daily for 22 days. At the conclu...Cholesterol drug could lead to new therapy for multiple sclerosis
...ns to transmit signals swiftly to one another. The destruction causes fatigue, disrupts various motor skills and, more subtly, diminishes some cognitive abilities. In later phases of the more progressive forms of the disease, non-inflammatory toxic molecules damage some of the brain's glial tissue and kill nerve...Rheumatoid arthritis patients caught in middle of doctors' disagreement over hand surgery
... felt that small-joint synovectomy could delay the destruction of a knuckle joint, compared with 12 percent of rheumatologists. Thirty-five percent of rheumatologists felt that operation was never a good idea for patients. These different world views on surgery are reflected in the state-by-state variation in s...Cedars-Sinai researchers detail events that enable brain tumors to weaken immune system
...tanding the mechanisms that enable tumors to evade destruction by the immune system. This gives us new tools in our fight against brain cancer, to essentially correct these deficits and further enhance the ability of the immune system, not only to detect but also to destroy brain tumors," said Keith L. Black, M....Researchers link the plaques and tangles of Alzheimer's disease
...markers and the death of neurons that leads to the destruction of the brain and the dementia characteristic of AD. Recent studies have established that beta-amyloid is toxic to neurons and that beta-amyloid activates caspases. Caspases cut targeted proteins during apoptosis, promoting the death of the cell. B...Drug may eliminate transfusions in patients with blood disorder
...eat hypersplenism, a condition marked by excessive destruction of one or more kinds of blood cells in the spleen. That patient received two transfusions preoperatively and one perioperatively. None of the original seven patients have received additional transfusions. All of the children reported they felt bet...Computer design yields better, more efficient therapeutic for preventing tissue damage
...ition, complement is thought to play a role in the destruction of cells during strokes, heart attacks, and burn injuries. The complement reaction is actually a series of interlocking cascades, or chain reactions, of biochemical events involving at least 30 proteins. Compstatin works by preventing the activation ...Research offers insight on treatment for hereditary eye disease
...he protein, death of the individual retinal cells, destruction of the retina and eventually blindness. "Basically, if we can stabilize the second domino after the first has fallen, we will be on our way for a cure to this disease that makes 1 million people go blind around the world," said Hwa. "We needed to u...NIEHS issues additional awards to continue 9/11 follow up
...t has characterized human exposures resulting from destruction of the buildings, examined respiratory, psychological and other reported health problems associated with the exposures, and communicated findings to residents and workers through a variety of forums. Sixteen institutions are receiving Worker Educa...Study finds way to dramatically increase hematopoietic stem cells
...a bone marrow transplant protocol including marrow destruction and the transfer of only a few stem cells on mice that had previously received PTH injections and on a control group. Where only 27 percent of the control mice survived for 28 days after transplantation, all of the PTH-treated mice survived, and exam...Study finds subtle brain damage in some HIV patients on drug therapy
...V response is generally an indication of damage or destruction to brain cells in the basal ganglia, a part of the brain that coordinates motor behavior and one of two brain structures where HIV tends to concentrate. Chao also found that among control subjects, the stronger their CNV activity, the faster their re...Regeneration of insulin-producing islets may lead to diabetes cure
...eloping this disease could be rescued from further destruction of their insulin-producing cells. In addition, patients with fully established diabetes possibly could have their diabetes reversed." Nathan has developed a protocol to test this approach in patients, but additional grant support is needed before a...Experimental drugs reduce neuron death in rats following insulin shock
...cal chain reaction is initiated that ends with the destruction of neurons, particularly in the hippocampus, a region of the brain instrumental in processing memories. Permanent memory impairment is a common and serious complication of severe hypoglycemic shock. Intravenous injections of glucose can reverse insul...New risk factor for heart disease identified
...Apolipoprotein(a) is thought to interfere with the destruction of a protein called fibrin which is involved in the development of atherosclerosis and thrombosis. Both these diseases come under the umbrella of 'heart disease'. Perhaps the smaller versions of apolipoprotein(a) promote these conditions more than th...New report presents options for oversight of genetic testing of human embryos
...le because it involves the creation, selection and destruction of human embryos. Third, there are questions of equity: many cannot afford PGD and it is not clear whether and to what extent health insurers will cover it. Finally, there are broad ethical questions about the impact of PGD on family relationships, ...