Lack of specific collagen type leads to osteoarthritis
...e that controls the production of type VI collagen developed osteoarthritis at a rate more than five times grea...lage of mouse joints, Leonidas Alexopoulos, Ph.D., developed a novel "micro-vacuuming" technique. With this device, Alexopoulos extracted key structures within t...Brain-scanning technologies need standards, according to Stanford researcher
STANFORD, Calif. - Researchers have developed ever more sensitive ways of peering into the brain to seek out explanations for brain disease. In most cases these technologies are good news for patients, bringing new ways of understanding health and treatment options. However, standards defining e...How often should women get mammograms?
...dra Lee, ScD, a biostatistician at Dana-Farber who developed the model along with Marvin Zelen, PhD, of Dana-Farber and the Harvard School of Public Health. "This is a preliminary tool to show policymakers the kind of information they can draw on to help them make decisions." Lee will describe the development ...Women should be advised not to drink alcohol in pregnancy
... reports into foetal alcohol syndrome, a condition developed by some babies exposed to alcohol in the womb, resulting in stunted growth, facial abnormalities and neurocognitive deficits (brain disorders). An overarching foetal alcohol spectrum disorder - traceable to the pregnant mother's alcohol consumption ...USC dental researchers develop first test for predicting cavities in children
...alnutrition and negligent oral hygiene are rare in developed societies: That leaves a child's genes as the prime determinant of his or her dental future. A different version of the test identifies the particular teeth at risk, Denny said. And the test's specificity may reduce the cost and increase the effectiv...Component of green tea protects injured livers in mice
...ted fatty liver cells from I/R injury. Researchers developed a technique to measure fatty acids and found that levels of palmitic and linoleic acid, two fatty acids that are present in large amounts in fatty livers, decreased significantly in EGCG treated mice. Further tests revealed an increase in hepatic ene...'Marital strain' increases women's risk of death, heart disease
...the participants for 10 years to determine if they developed heart disease or died. "Married men were heavier, older, and had higher blood pressure and a less favorable lipid profile compared to unmarried men," Eaker said. "Unmarried men were more likely to be smokers." After the researchers made statistica...Miniaturized lab permits saliva screening on the go
...niel Malamud at the University of Pennsylvania has developed a robust means of analyzing oral samples. They believe their work will lead to a kit, not much bigger than a credit card, which could detect exposure to a variety of substances, from narcotics to anthrax to common bacteria and viruses. Their plan w...Gene signature can predict breast cancer spread
...and found it could accurately predict patients who developed distant recurrence within five years (93% sensitivity) but was less accurate at predicting patients whose disease did not return within 5 years (48% specificity). Dr Foekens concludes: "Since only 30-40% of untreated lymph-node negative patients deve...International gathering of experts to share retinoblastoma breakthroughs
...hout the body and caused cancer. Dyer's laboratory developed the first mouse model in which the mutation occurs only in the retina, which permitted the use of the model for testing new drugs to treat this cancer. "This symposium is historic because of the people it brings together at a single site to discuss ...'EuroVacc 02' HIV vaccine trial begins in February 2005
...s for the trial - DNA-HIV-C and NYVAC-HIV-C - were developed within the network European Vaccine Effort against...s safe and immunogenic. The DNA-HIV-C vaccine was developed by Professors Hans Wolf and Ralf Wagner at the University of Regensburg based on a representative Ch...Researchers track program's success in curbing aggressive behavior
... unique because its rigorous scientific design was developed in partnership with the Baltimore schools and communities, and it demonstrates long-term benefit into adulthood of an intervention begun in first grade. It shows helping all children in a classroom benefits those at most risk, without labeling or iso...Small increases or 'blips' in HIV levels do not signal mutations leading to drug-resistant HIV
...ilable combinations is limited for people who have developed drug resistance....An implanted nerve stimulator helps drop foot sufferers walk faster and better
...he partners in EUREKA project E! 2526 IMPULSE have developed an implanted nerve stimulator which helps patients...in," explains Hermens. The project used technology developed by the UK project partner, FineTech Medical, through its work on bladder stimulation. The device is ...Test could improve detection of prion disease in humans
...mation-dependent immunoassay (CDI), was originally developed to detect various forms of disease-causing proteins called prions in cows, sheep, deer and other animals. In the new study, researchers led by Jiri Safar, M.D., Bruce Miller, M.D., Michael Geschwind, M.D., Stephen DeArmond, M.D., and Nobel Laureate S...A new method for early detection of disease outbreaks
...ds existed. Martin Kulldorff and colleagues have developed and operated real-time disease surveillance systems based on electronic records. In an article published in the open-access medical journal PLoS Medicine , they now report a new and very flexible approach for early disease outbreak detection. Th...Promising treatments for Huntington's disease identified in UCI study
...e Thompson found that combinatorial drug therapies developed from these compounds halted the brain-cell damage ...ound that drugs called HDAC inhibitors, which were developed for cancer chemotherapy, were able to prevent neuron damage in fruit flies carrying mutated Htt prot...Northwestern Memorial Hospital receives $10 million commitment to support preeminent heart program
...y of them pioneered by Dr. McCarthy. Dr. McCarthy developed several products for heart valve repair and minimally invasive heart surgery. Also, Dr. McCarthy immediately brought a recent development in pain management to all cardiac surgery patients at Northwestern Memorial, making it one of the first hospita...Stem cell therapy for spinal injury
...o the injury level, scientists found that the rats developed greater pain sensitivity just superior of it. In ... to be the result of the fact that many stem cells developed into astrocytes, a kind of glial cell that encourages the growth of pain axons in the spinal cord by...Penn joins major NCI research initiative to advance breast cancer therapies
...MHCC sites at which breast-cancer models are being developed and studied. Chodosh will oversee a $2.5 million, five-year program based at Penn that encompasses multidisciplinary research from six institutions in three countries. Chodosh's co-principal investigators are: Mitchell D. Schnall, MD, PhD, Associate ...