Clinical trial of Etanercept for Wegener's disease shows no benefit
...ibuted to conventional medications. Solid cancers developed in six patients in the etanercept group, however, compared with none in the placebo group. "The number of malignancies observed is too small to draw any firm conclusions," noted Stone. "There is certainly the potential for interaction between TNF ...Study sheds light on cross-species infection for BSE
... brain tissue from a BSE-affected cow. One primate developed a neurological disease closely resembling vCJD 5 years after exposure, whereas the other remained free of disease. On the basis of these findings and data from other studies the investigators estimated that the efficiency of infection from cow to pri...Biochip for detection of inflammatory bowel disease
...untry, pioneer in this field in Spain, has already developed other, similar products. An example is the Lipochip developed for the Lcer pharmaceutical company and which diagnoses family hypercholesterolemia. The Lipochip wa...Reviparin effective in reducing risk of death after heart attack
...relatively straightforward and can be used in both developed and developing countries. Therefore, the benefits of reviparin represents a moderate but important globally applicable advance in the management of patients with acute MI," the authors conclude. (JAMA. 2005;293:427-436. Available post-embargo at JAM...Rice scientist recognized as pioneer in tissue engineering
...kos. Over the past 13 years, Mikos' laboratory has developed extensive expertise in fabricating synthetic mater...e them once they are implanted. Mikos lab has also developed techniques for growing new bone and cartilage tissue by seeding the scaffolds with cells. Because th...Vaccinating school children and high risk groups is best strategy for slowing flu transmission
...ative vaccine plan is based on mathematical models developed by Ira Longini, PhD, and Elizabeth Halloran, MD, DSc, professors of biostatistics in Emory's Rollins School of Public Health, and on influenza field studies. The report will be published in the February 15 issue of The American Journal of Epidemiol...A global treatment for iron deficiency
...onal problem. It has largely been eradicated from developed countries, but more than 750 million children in t...n their homes." Importantly, the authors have developed a collaborative model to scale up the intervention for countrywide use, including providing Sprinkle...Case definition for polyneuropathy developed to standardize research
...ion for distal symmetrical polyneuropathy has been developed by the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. The definition is published in the January 25 issue of Neurology, the scientific journal o...New leukemia drug shows promise in overriding all Gleevec resistance
(PHILADELPHIA) Temple University researchers have developed a new drug that could potentially treat all forms ...pear to be mutating and adapting to Gleevec. "We developed ON012380, a compound that specifically inhibits BCR-ABL by blocking a different site in the protein,...NIAID begins enrolling volunteers for novel HIV vaccine study
... the pharmaceutical company Merck & Co. Inc. Merck developed the experimental vaccine to stimulate HIV-specific cellular immunity, which prompts the body to produce T cells that kill HIV-infected cells. In previous smaller trials, this vaccine was found to be safe and to induce cellular immune responses agains...Vioxx went mostly to patients who didn't need it, Stanford researcher says
... causing the gastritis and ulcers that some people developed from taking ibuprofen, naproxen and other painkill...nued or prescribed. Additionally, they used a tool developed at Stanford in the 1990s to categorize patients according to their risk of gastrointestinal bleeding...Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems
...e risk for side effects from the drugs COX-2s were developed to replace. "We found a rapid nationwide shift away from older, inexpensive drugs with better established safety and efficacy to newer, costly drugs with no real history," said study author G. Caleb Alexander, M.D., M.S., instructor of medicine and a...Rebuilding wounded veterans: Annual review of limb loss & prosthetics research
...volutionize prosthetic limb fitting Investigators developed a classifica-tion system to better match elastomeric liners (stretchy socks worn between residual limbs and prosthetic sockets) with the needs of patients with amputations. The newly-developed classification system will guide elastomeric liner prescr...JCI table of contents, January 20 2005
...llips and colleagues from the University of Oxford developed a highly sensitive technique to visualize, quantif...The study demonstrates how the immune response has developed to safeguard self-tolerance yet also promote our capacity to deal with foreign invaders. ...T cells target HIV in a relationship on the rebound
...llips and colleagues from the University of Oxford developed a highly sensitive technique to visualize, quantify, and track the HIV-specific CD4+ T cell population in patients with early-stage HIV infection who were given a short, fixed course of antiretroviral therapy. They found that return of viral replicat...Technology that could double the effectiveness of cancer drugs studied at Yale
... of treatment if it proves ineffective." Mor's lab developed the Yale apoptosis assay based on a biological principle that when a drug is effective, it will induce apoptosis (cell death) in the cancer cell. If the cancer cell is resistant to a drug, apoptosis does not occur. Mor said, "The Yale apoptosis assay...Male circumcision reduces risk of HIV transmission from women to men
...ale Kenyan truckers and, using statistical models, developed infectivity measures that estimate the per-sexual-act probability of HIV transmission. The study is the first to calculate the probability of infection for men who have multiple, concurrent heterosexual partners, which was found to be significantly h...University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
...s. Scientists at The University of Manchester have developed the breakthrough technology which will allow tailor-made tissues and bones to be grown, simply by inputting their dimensions into a computer. Professor Brian Derby, Head of the Ink-Jet Printing of Human Cells Project research team, said: "It is diffi...Simpler 'alphabet' guidelines for treating acute coronary syndrome reduce risk
...Association. The new guidelines are based on those developed by the American College of Cardiology (ACG),the American Heart Association (AHA) and the results of recent clinical trials, and include risk-factor reduction, lifestyle changes and drugs. To develop the guidelines, the researchers reviewed all of th......he AIDS Vaccines Advocacy Coalition. The plan, developed with the collaboration of over 140 scientists worldwide, identifies the major scientific roadblocks facing HIV vaccine development, outlines a strategic approach to addressing them, and proposes an innovative collaborative model that ensures that res...