Chemical turns stem cells into neurons say scientists at Scripps Research Institute
...ntial in medicine because they have the ability to differentiate into many different cell types--potentially provid...mmune system. Because stem cells have the power to differentiate into islet cells, stem cell therapy could potentially cure this chronic condition. However bright th...Household falls may produce more severe brain injuries in infants than previously thought
...es and her colleagues may help abuse investigators differentiate accidental falls from injuries caused by the striking of a child's head against a surface. Brain injuries -- accidental and inflicted -- hospitalize or kill an estimated 150,000 children annually in the U.S. "Traumatic brain injury is the most commo...JCI table of contents, 1 August 2003
...ocytes stably expressing the Foxa-2 protein do not differentiate into mature fat cells. Furthermore, in multiple rodent models of obesity they observed that Foxa-2 production is increased, in what may be an important counterregulatory mechanism to prevent the expansion of fat cell numbers. While the stimuli that i...Fred Hutchinson Cancer Research Center study shows retinoids kill childhood brain tumor cells
...ma and other cancers because they trigger cells to differentiate (form specialized cells) and stop dividing," he said. "But we observed that when the compounds are applied to medulloblastoma tumors, a large percentage of cancer cells actually die." Retinoids are molecules naturally produced by the human body, wher...SFVAMC researchers distinguish dementias using brain imaging
...nd a related technique knows as MR spectroscopy to differentiate between the two kinds of dementia. Their work offers hope of improving the treatment of dementia in patients with poor blood flow, such as stroke victims, and the testing of drugs to treat Alzheimer's disease (AD). "Currently, there are no effective ...Purdue food scientists improve testing of health supplements
...ier-transform infrared spectroscopy (FT-IR), could differentiate between each one. Then they mixed various amounts ...his is the first time this method has been used to differentiate a whole spectrum of food samples, such as the 19 oils used in the study, instead of only comparing t...Emory School of Medicine receives $16 million NIH grant to lead biodefense consortium
...grant. "These molecular 'signatures' will help us differentiate between 'good' and 'bad' vaccines," Dr. Ahmed explains. "And this knowledge should allow us to manipulate these immune responses to either enhance immunity in the case of vaccines and immune therapy or to decrease immune responses in autoimmune dise...Researchers now on road to isolating skin stem cells
... better understand the process by which skin cells differentiate and, since skin cancer likely originates in stem cells, better understand--and maybe someday better treat--skin cancer. Additional authors include Tracy E. Schneider, BS, Chantal Barland, MD, and April M. Alex, MS, of the UCSF Department of Dermatolo...Bone cells help call the shots for the blood's stem cells within
... to expand stem cells, but they cause the cells to differentiate also," says Calvi. "There's not really much you can do to expand the hematopoietic stem cell population. It turns out that it's the osteoblast, right in the bone, that is able to do that." The ability to expand stem cells would be especially welcome...Jefferson scientists show low lead levels can affect development of brain cells
...gnificantly inhibited the ability of stem cells to differentiate into either neurons or oligodendrocytes, but increased their ability to become astrocytes, he explains. Dr. Schneider presented these findings Sunday, Nov. 9 at the annual meeting of the Society for Neuroscience in New Orleans. Young women who were...Bone marrow cells improve failing heart function
... in oxygen-deprived tissue. Mononuclear cells can differentiate into tissue and new blood vessels, and secrete a wide variety of proteins and growth factors, said Perin, who is also director of new cardiovascular interventional technology at the Texas Heart Institute. Treated patients had better blood flow and c...Universal bone marrow cell spurs growth of vessels and heart muscle
...ow includes a clonal stem cell population that can differentiate into both vessels and heart muscle. These cells c...se adult bone marrow stem cells have been shown to differentiate into all three so-called "germ layers." The three germ layers of cells in early human development a...Cardiac MRI detects thinned heart muscle previously deemed unsalvageable
...tails not seen before," Shah said. "The ability to differentiate between living and dead cells makes MRI a more direct measure of tissue viability than any other method." During a cardiac MRI examination, which is non-invasive and radiation-free, a patient is guided through the cavity of a large doughnut-shaped ma...Stem cell and other new biological therapies are target of major NIH contract to U of MN
...ave shown that adult bone marrow-derived cells can differentiate into many types of cells, including liver, pancreas, and brain. These multipotent adult progenitor cells (MAPCs) are a major focus of potential stem cell treatments. Wagner is also investigating the use of umbilical cord blood to treat children and ...Imaging technique may diagnose breast cancer without biopsy
...els in breast masses, which limited the ability to differentiate between benign and malignant lumps detected by MRI. "We found tCho concentrations to be significantly higher in malignancies than in benign lumps and normal breast tissues using this quantitative method," said lead investigator Michael Garwood, Ph.D...Duke cardiologists offer new view of link between aging, atherosclerosis
...nts: or to retrain the patient's own stem cells to differentiate into progenitor cells capable of arterial repair. "Our studies indicate that the inability of bone marrow to produce progenitor cells which repair and rejuvenate the lining of the arteries drives the process of atherosclerosis and the formation of pl...New dynamic PET technique offers greater comfort for cancer patients
...SUV), which does provide some quantifiable data to differentiate between benign and malignant growths, but a dynamic PET scan can provide additional data about the rate of uptake and the movement of 18F-FDG through the body and tumor(s). This data, when analyzed mathematically, provides a more complete diagnosis. ...Bone marrowderived stem cells active in pulmonary fibrosis
...een thought to be restricted in their potential to differentiate and regenerate tissues in which they reside. A study by Sem Phan and colleagues from the University of Michigan, in the January 15 issue of the Journal of Clinical Investigation, suggests that the collagen overproduction and deposition in the lung ca...Scientists grow neurons using nanostructures
... present in the central nervous system and able to differentiate into different types of cells) the nanofiber scaffolds formed and led quickly to the selective differentiation of the cells into neurons. In subsequent experiments, the researchers successfully delivered the peptide amphiphile solution, using a simp......ure to antigen, nave T cells in normal individuals differentiate into T cells that produce IL-10, and possibly TGF- beta, subsequently inhibiting cells that would normally mediate an aggressive immune response. The results reported by Peakman and colleagues suggest that in patients with T1DM, there is instead indu...