Blocking pathway overcomes tumor vessel resistance to radiation
...earch, shows a potential way to overcome an ironic discovery found in the study. The radiation therapy intended to kill the blood vessels that feed cancer cells can actually trigger a chemical pathway that makes the vessels more resistant to therapy. "We know that if vascular endothelium is destroyed, tumor c...Rutgers research shows caffeine may prevent skin cancer
...djacent normal skin cells were not affected. "The discovery of this selectivity was very exciting to us," said Conney. "Also, in our study it didn't matter if the tumors were benign or malignant; cells in both were killed while leaving the normal cells alone." The study suggests further research is needed t...Drug protects fertility, offspring in mice after radiation exposure
...function without propagating genetic damage." The discovery provides hope for women who undergo cancer treatments and want to preserve their fertility. "But," Dr. Fuks adds, "this is still translational research, and there is still much work to be done." Further research is being planned, he said....Media focus on endostatin helped -- not hurt --
...front page story on May 3, 1998, that heralded the discovery and development of an agent called recombinant human endostatin (rh-Endo), an angiogenesis inhibitor designed to dry up a tumor's source of blood, starving it. In the article, researchers predicted endostatin might quickly prove to be a cure for canc...Chemists show proteins behave differently inside cells than they do in water solutions
...sure them." "What impresses me the most about this discovery is the clear demonstration that the environment of proteins in real life situations -- the proximity of billions of other molecules such as lipids, sugars, salts and water, for example -- has a profound influence on their three-dimensional structure,...Researchers show new genetic mutation increases risk for colon cancer
...tudy. "The interesting aspect of this study is the discovery of a possible novel pathway for colon cancer in humans, which had not previously been suggested in laboratory models," said Kenneth Offit, MD, Chief of the Clinical Genetics Service at Memorial Sloan-Kettering, and senior author of the paper. It was ...Futile cycle both fights diabetes and causes weight gain
...e how our bodies process and use fats. Future drug discovery may depend on the role of fat itself." ...Gene found that helps nerve cells survive by preventing cell suicide
...er injury while others shrink away and die? A new discovery by researchers at Massachusetts General Hospital (MGH) shows that the expression of a particular gene may be responsible for protecting neurons from death. The results, published in the September 26 issue of Neuron, could lead the way for new treatm......d to find clinically relevant applications for the discovery of new genes and molecular pathways in the laboratory. Only in this way can innovative cancer treatments be rationally designed and tested."...NIDA and SAMHSA agreement expedites transfer of research findings to clinical practice
...Services" cycle and to reduce the time between the discovery of an effective treatment or intervention and its adoption as part of community-based care. Today, the Institute of Medicine tells us it can take up to 20 years." Under the agreement, NIDA will provide funding to support CSAT's Addiction Technology ...Initial Avon/NCI breast cancer research grants awarded in 'Progress for Patients' awards program
...ent by Avon will help NCI to close the gap between discovery and delivery in breast cancer research," von Eschenbach said. In addition to the Progress for Patients funding, the Avon Foundation maintains a comprehensive philanthropic program that supports junior investigators and areas of great promise in resea...Chemists create synthetic cytochromes
... without the peptide. The scientists report their discovery in a paper in the Oct. 23 issue of the Journal of the American Chemical Society. Cytochromes are heme proteins; that is, the iron is held in the central hole of a doughnut-shaped heme. Related to hemoglobin and myoglobin -- the red-colored proteins ...Most definitive study of its kind shows that sleeping on the stomach increases infant SIDS risk
...ns about: the events preceding the infant's death, discovery of the deceased infant, the medical history of the infant and family, as well as maternal alcohol, tobacco, and drug abuse before and during pregnancy. The study relied primarily on the ability of mothers and family members to recall events regarding...New avenue of HIV damage found
... for the cells to divide." One implication of this discovery is that through testing of the lymph nodes (similar to what is done to stage cancer), physicians might accurately stage the disease and predict the response to standard therapies. "This is essentially a new concept in how HIV infection causes dama...New compound holds promise for lupus and related diseases
...the novel mechanism by which the compound works, a discovery that could lead to safer and more effective new drugs for managing lupus and other autoimmune disorders. "The best available therapies for lupus haven't changed for many, many years," says U-M's Gary D. Glick, Ph.D., one of the lead authors on the s...OHSU chemoprotectant technology licensed for biotechnology development
...the Blood Brain Barrier Program at OHSU and on the discovery of therapeutics that protect against the adverse side effects associated with certain chemotherapy drugs. For example, his group is studying a chemoprotectant, N-Acetylcysteine (NAC), for the prevention of bone marrow suppression and mucosal damage l...UCLA geneticists find location of major gene in ADHD; targeted region also linked to autism
...Center for Neurobehavioral Genetics focuses on the discovery of the genetic basis of major neurobehavioral disorders, including autism, attention deficit hyperactivity disorder, dementias, depression, manic-depressive illness (bipolar disorder) and schizophrenia....Researchers discover 'doorways' into brain cells
...rface of nerve cells that regulate such entry. The discovery of such entry points drastically revises a long-he...hogens such as viruses. The researchers said their discovery of the zones raises the possibility that drugs affecting receptor transport to and through the zones...Glucocorticoid use increases risk of spinal fractures
... treating and preventing human disease through the discovery and development of innovative pharmaceutical products. Aventis focuses on prescription drugs for important therapeutic areas such as oncology, cardiology, diabetes, respiratory/allergy, anti-infectives as well as on human vaccines. In 2001, Aventis ...... treating and preventing human disease through the discovery and development of innovative pharmaceutical products. Aventis focuses on prescription drugs for important therapeutic areas such as oncology, cardiology, diabetes, respiratory/allergy, anti-infectives as well as on human vaccines. In 2001, Aventis ...