Researchers model brain's electrical storm during a seizure
...hope of doing something to change the situation by disrupting the signal." Much like a computer model can reveal more about the structural integrity of a building or the causes of a developing hurricane than is practical or desirable through direct observation, a computer simulation of a brain during a seizure...Study suggests Akt3 protein is key to melanoma's resistance to chemotherapy
...he amount of a specific protein produced by a cell disrupting the synthesis of the protein. In Robertson's study, the siRNA were designed specifically to target Akt3. In addition, he put back the PTEN protein in the melanoma cells. This restarted the normal signals triggering cell death that had been halted by ...Disruption of a gene may prevent type 1 diabetes, UVa researchers find
...Va. researchers discovered for the first time that disrupting Stat-4 completely prevented the development of spontaneous diabetes in a mouse model, revealing an important role for the Stat-4 gene in the pathogenesis of type 1, also known as autoimmune diabetes. Type 1 diabetes occurs when the body's immune syst...Iressa news backgrounder: Testing of smart drug expands at M. D. Anderson Cancer Center
...urface or by using the receptor as an entry point, disrupting molecular signals that stimulate cell growth. A wide variety of cancers, such as lung, breast, ovarian, bladder, prostate, colorectal, kidney and head and neck cancer over-produce EGF proteins and some of these tumors may be especially dependent on t...Discovery sheds light on how cancer cells grow and divide
...ory manipulations of mammalian cells that included disrupting the centrosome, the research team was able to demonstrate that Dynamin-2 is a normal and necessary component of the centrosome. "When we reduced the levels of dynamin in cells, this led to an impairment of the centrosome," Dr. McNiven explains. The r...Heart disease and stroke hit younger in developing countries, new report shows
...s far greater than has previously been understood, disrupting families and the work force in developing countries. While cardiovascular diseases (CVD) are often portrayed in the West as diseases of affluent and older people, CVD mortality rates among working age people in India, South Africa, and Brazil are on...Making smart drugs that deliver the right kind of punch
...ut how to get dendrimers into cancer cells without disrupting healthy cells. Previous work had shown that high concentrations of dendrimers are toxic---even without their cancer drug cargo---but no one was sure why that was or what could be done about it. Mecke used an atomic force microscope---a device so sens...When it comes to allergies, Americans don't make the grade
... allergies do not impact their quality of life, by disrupting daily activities or preventing attendance at important events." The Test, conducted by International Communications Research, surveyed 1,005 Americans and is part of AAFA's nationwide Allergy Action Plan to help consumers recognize, prevent and safel...Detection at a distance for more sensitive MRI
... from samples, including living organisms, without disrupting them," says Pines, noting that MRI, a closely related technology, is equally adept at nondestructively picturing the insides of things. "The problem with this versatile technique is low sensitivity." "However," says Han, "by separating the encoding ...New animal model for Alzheimer vaccine
..., a protein fragment considered a prime suspect in disrupting and destroying nerve cells in the Alzheimer brain. The vaccinated monkeys developed significant levels of antibodies to beta amyloid as well as high levels of beta amyloid circulating in their blood, much of it attached to antibodies. Two other mon...Hormone released by bone marrow cells may hasten recovery from brain injury
...ecovery from stroke or other neurological injuries disrupting blood flow to the central nervous system, researchers at the University of South Florida and James A. Haley Veterans' Hospital report for the first time. The hormone is known as brain natriuretic peptide. The laboratory study was published in the Jan...Book explores how children use imagination to battle chronic illness
...to be aware of how children cope, if only to avoid disrupting it, she said. "Play is a way for kids to express their feelings in a tangible form they can manage even at a young age. Play allows members of a family to interact, and to sustain shared ways of understanding illness," said Clark. "Even if play see...Mayo Clinic researchers discover how key cancer protein works
...c kind of biochemical modification was involved in disrupting the cell cycle to cause BRCA1 mutations. And they were right. "With this breast cancer gene, the understanding is that if this gene is mutated it may trigger additional mutations throughout your lifetime and that contributes to a lifetime risk of de......urface or by using the receptor as an entry point, disrupting molecular signals that stimulate cell growth. A wide variety of cancers, such as lung, breast, ovarian, bladder, prostate, colorectal, kidney and head and neck cancer over-produce EGF proteins and some of these tumors may be especially dependent on t...New insight into heart failure suggests novel drug target
DURHAM, N.C. -- By disrupting the activity of a single heart protein, Duke Unive... beta-adrenergic receptors on the heart surface by disrupting PI3Kgamma activity leads to improved heart function, a result supporting the idea that the loss of r...Nanoneurosurgery, search for E-T life, bioscan technology and home holograms at frontiers of optics
... in the organism without killing the nerve cell or disrupting the surrounding tissue. Compared to traditional biochemical or mechanical methods of manipulating tissue, femtosecond micromanipulation is more selective and precise and less invasive, opening the door to many new studies, which the researchers are ...Trends in private Medicare+Choice plans provide warnings for Medicare debate
...or simply withdrawn from local markets altogether, disrupting health care for more than 2.4 million beneficiaries from 1999 to 2003. Any new Medicare program that depends on private plans is likely to face the same circumstances. Lesson #4: Physician and hospital participation has been unstable. Medicare+Choi......eads to cognitive impairment, as well as seriously disrupting the immune and hormone systems, although it is not known how long these effects last. And Paul Blake of Cephalon acknowledges Provigil's limitations: "The drug isn't a replacement for sleep," he says. On the other hand, Provigil could help prevent ac...First trial of endostatin shows biological activity
...ent was decreasing blood flow to tumors as well as disrupting metabolic activity within the tumors. They began PET measurements before therapy and at monthly intervals, and found that both blood flow and tumor activity generally decreased with increasing doses of rh-Endo. "But these effects were complex, not a ...Potent experimental drug shown to slow the growth of breast and prostate cancer tumors in mice
...r Herceptin. They found that 2C4 was effective in disrupting communication among HER-2 and HER-3 and between EGFR and HER-2, but Herceptin was not. "This means that 2C4 has the potential to turn off the entire HER-kinase signaling axis in solid tumors, as most solid tumors have some HER-2/neu on their cell s...