Disulfiram and cognitive behavioral therapy appear effective for treating cocaine dependence
...ne of the JAMA/Archives journals. Patients taking disulfiram who ingest even small amounts of alcohol develop a... be less likely to abuse cocaine. However, use of disulfiram has not been evaluated in general populations of cocaine users. Kathleen M. Carroll, Ph.D., from Yal......racellular mission by giving patients a drugcalled disulfiram before anesthesia. "We manipulate the acti...ld 'turn off' P450 2E1,"Kharasch said. The disulfiram is itself transformed in the liver into a chemical thatinactivates P450 2E1 by binding to it and pre...