Regulatory T cells keep graft-versus-host disease in check
...gulatory CD4+CD25+ T cells can induce tolerance to donor tissue following allogeneic hematopoietic stem cel...urified CD4+CD25+ regulatory T cells from a single donor patient to achieve this therapeutic effect in a clinical setting. In the December 4 issue of the Jou...Mechanical support could increase survival of children requiring heart transplantation
...ee rescue. Only a more readily available supply of donor organs can provide the assurance of a rescue procedure for children with acute heart failure."...Mayo researchers observe genetic fusion of human, animal cells -may help explain origin of AIDS
...or humans to meet the drastic shortage of suitable donor organs. Worldwide, thousands of people suffer fail...ants -- but face death due to shortage of suitable donor organs. Xenotransplantation is just one experimental avenue being explored as a way to meet this sho...New report presents options for oversight of genetic testing of human embryos
...s, to select embryos that will be a matched tissue donor for an ailing sibling and to select embryos based on sex. PGD raises a number of scientific, ethical and policy issues. First, there are questions about the safety of the in vitro fertilization and embryo manipulation required for PGD and about the a...7-month-old is youngest recipient of artificial corneal transplant
...lphaCor, an artificial cornea that doesn't require donor tissue. The flexible, one-piece keratoprosthesis i... models, cutting down on surgery time. The lack of donor tissue means the risk of rejection is eliminated. The new implant offers significantly more possibil...Gene therapy technique could aid islet transplants for diabetes, says Pittsburgh study
... is similar to transplanting islets from one human donor into a different recipient). They also delivered the islets into the portal vein (as is performed in humans) instead of through a kidney capsule graft (used in their prior studies in mice). Finally, researchers used the standard combination of immuno...Blood transfusion poses CJD risk
...had previously received a blood transfusion from a donor who went on to have vCJD was announced on December...ells donated by an individual 3.5 years before the donor developed symptoms of vCJD. Robert Will comments: "Our findings raise the possibility that this infe...International grant supports study related to preventing organ rejection
... a recipient's immune system accept and maintain a donor organ, but the drugs themselves can ultimately contribute to rejection or death. Specifically, the grant will support Zavazava's work on animal models to understand how embryonic stem cells are accepted into a recipient cell system and are able to di...Pitt receives $14.5 million from NIH to improve pediatric heart transplantation outcomes
...ique trial involving the inoculation of unmodified donor bone marrow into the thymus during heart transplan...cedure compared to 23 patients who did not receive donor bone marrow. Through the grant, these patients will continue to be followed and a second group of pa...Database on blood and marrow stem cell transplants now available online
...rs can generate and test hypotheses on the role of donor matching in blood and marrow stem cell transplants...ic tools that provide greater predictive value for donor matching than current methods," says Daniel Rotrosen, M.D., director of NIAID's Division of Allergy,...Religion guides views of fertility treatment in Middle East
...o do a muta'a, or temporary, marriage with any egg donor so the child is not born out of wedlock. However, since a married Shi'ite Muslim woman cannot marry another man sperm donation from a man other than her husband is akin to adultery. Middle Eastern societies expect all married couples to produce biolo...Cord blood cells proven to differentiate into heart muscle and brain cells
... dissected heart tissue to confirm the presence of donor stem cells in heart tissue. Moreover, they showed that donor stem cells had differentiated into heart muscle cells called myocytes, which then produced the criti...Duke physicians predict risks of deadly infections after cord blood transplants
...e out of six of the major HLA molecules with their donor suffered fewer life-threatening infections than ch... mismatch of HLA molecules between the patient and donor can interfere with immune cell messages that must connect in order for the body to recognize an infe...U of M researchers a step further in Type 1 diabetes treatment
...n of insulin-producing "islet" cells from a single donor pancreas. Individuals in whom Type 1 diabetes w...ence can be induced in Type 1 diabetes with single donor islet transplants is quite important because it will allow an increased number of islet transplants ...Ethical review of research in developing countries needed
...ard in collaborative research in both the host and donor country, but international guidelines for collaborative and multi-national research projects are needed. It is also important to make sure that there is a strong voice from the developing world in all discussions pertaining to this issue and that suc...Study shows 'gaming' in heart transplant system
...POs. Since long transportation time could damage a donor heart, when a heart becomes available, UNOS looks to place that organ within the same OPO so it may be transplanted more quickly. Some regions have only one hospital that performs heart transplants, while others distribute organs among as many as nin...An alternative to bone-marrow donation
...e marrow. Despite the genetic mismatch between donor and recipient, the injected cells were not rejecte...ny potential advantages over the use of cells from donor bone marrow or blood. The latter cells are highly variable, cannot be cultured in the lab and often ...Research questions transplant safety procedure
...distribution of tissues from a single HIV-infected donor resulted in the dissemination of 52 virus-contamin...the risk of implanting tissue from an infected HIV donor is less than one in a million." This work earned LCOR the 2004 Cabaud Award, an honor giv...Embryonic stem cells induced to develop into bone marrow and blood cells
...r injection. Despite the genetic mismatch between donor and recipient mice, the injected cells were not re...troversial, it has many advantages over the use of donor bone marrow or blood cells, which are highly variable, cannot be cultured in a laboratory, may cause...