Tag: "dopamine" at medical news

An anti-nicotine drug reduces the rewarding effects of alcohol

...e activity of another neurotransmitter system, the dopamine system, which is where most drugs are thought to p...s which would, in turn, reduce the activity of the dopamine system, resulting in a dampening of the rewarding effects of the alcohol." Researchers recruited 27 ...

Parkinson's medication linked to gambling

...de effect in Parkinson's patients who take certain dopamine agonists, according to a study in the August 12 is...their patients taking relatively high dosages of a dopamine agonist, and with a documented history of depression or anxiety disorder." The nine patients were ta...

Study shows new drug reduces advanced Parkinson's disease symptoms

...fter 40 years of treating Parkinson's disease with dopamine medications, a new study shows potential for a non...ss and stiffness as the disease advances. Current dopamine replacement therapy improves those symptoms, but after several years the treatment becomes complicat...

Taking Ecstasy during pregnancy may cause brain damage, behavior problems in babies

... exposed rats had a 502% increase in the number of dopamine neuron fibers in the frontal cortex as compared to controls. The frontal cortex is important in planning, impulse control and attention. Similar but smaller increases in dopaminergic fiber density were also evident in the striatum -- an area involve...

FDA approves Wellbutrin XL(TM)

...s the first and only once-daily norepinephrine and dopamine reuptake inhibitor (NDRI) for the treatment of depression in adults. The active ingredient in Wellbutrin XL bupropion hydrochloride is believed to act upon norepinephrine and dopamine, two chemicals in the brain known to help regulate different asp...

Rat study shows exposure to Ecstasy early in pregnancy induces brain, behavior changes

...d pups had a 502-percent increase in the number of dopamine neuron fibers in the frontal cortex compared with ...ientists also saw similar but smaller increases in dopamine fibers in the striatum (a brain area involved in locomotion and reward) and the nucleus accumbens (t...

UGA, MCG study impact of long-term use of schizophrenia drugs

... receptors in their brain, you see that they block dopamine receptors so they don't have as many psychotic outbursts. Patients are quiet, docile and more easily managed but their cognition becomes impaired, and it's worse than it would have been without treatment. What we are in the process of doing is eva...

New clinical research study evaluates novel cell therapy

...e as a new potential source of levodopa to enhance dopamine production where it is most needed. An earlier pilot clinical study at Emory University implanted six advanced Parkinson's patients with cells on one side of the brain. These six patients experienced sustained improvements in motor function, averagin...

Anticonvulsant drug promising therapy for cocaine abuse

... Institute on Drug Abuse. "Using GVG to temper the dopamine system may very effectively block the addiction-related effects of cocaine." A total of 19 men and 1 woman entered the study. Eight people completed the trial in which they received escalating doses of GVG for the first week until they reached the hi...

Results from first clinical trial using GVG to treat addiction

...that GVG can block drug-induced increases in brain dopamine (a chemical associated with reward and pleasure, which is elevated by all addictive drugs), drug-seeking behavior, drug self-administration and sensitization, and drug craving -- even that triggered by environmental cues (see http://www.bnl.gov/PET/...

Epilepsy drug can stop cocaine use in addicts

...g that the treatment in animals blocks the rise in dopamine levels produced by cocaine, nicotine and many other addicting substances. Dopamine is a brain chemical associated with the pleasurable effects of addicting drugs. The animal studies drew the interest of Dr. Figueroa, who treats addicts at the...

New Penn study shows genes may influence smoking cessation

... provides the first evidence that genes that alter dopamine function may influence smoking cessation and relap...articipants with particular variants of the SLC6A3 dopamine transporter gene and the DRD2 dopamine receptor gene reported significantly higher abstinences rates...

Several commonly used pesticides are toxic to mitochondria in laboratory experiments

...els of rotenone caused gradual degeneration of the dopamine neurons in rats, and reproduced many of the features of Parkinsonism. In the new study, the Emory scientists exposed human neuroblastoma cells to the pesticides rotenone, pyridaben, fenazaquin, and fenpyroximate, all of which inhibit complex I. Pyr...

Baclofen holds promise for cocaine treatment

... by inhibiting the release of the neurotransmitter dopamine in the brain, undercutting the "high" caused by cocaine. The study involved 70 outpatients who underwent a 16-week cocaine addiction treatment program. Half the participants received baclofen and counseling and half received a placebo, or sugar pill,...

Concord grape juice improved memory and neuro-motor skills in animal study

...otential mechanisms of action, including increased dopamine production and a potent overall antioxidant effect. According to previously published USDA studies, Concord grape juice has the highest total antioxidants of any fruits, vegetables or juices tested. "As our population ages, we are contin...

Clozapine effective for controlling dyskinesias in people with severe Parkinson's

...e thought to result from increased transmission of dopamine in the brain. Clozapine may be able to mitigate the transmission of toxically high levels of levodopa and thereby reduce its potency and lesson the severity and duration of LIDs, according to the study. "Overstimulation of D1 dopaminergic receptors i...

A new protective protein against Parkinson's disease

...ure of the nigrostriatal pathway leads to profound dopamine deficiency, causing bradykinesia, tremor and rigidity. Since the deficit in striatal dopamine is the main cause of PD symptoms, it appears critical to preserve axon terminals to ensure healthy f...

Crystal methamphetamine use increases HIV risk

...motor and verbal skills. Methamphetamine decreases dopamine transporter levels, causing symptoms akin to those of Parkinson's disease, and when combined with HIV's toxic effects on the brain, "there's an overlap in neurotoxicity between methamphetamine and HIV," said Dr. Urbina. "That's potentially the most s...

Success of nicotine patches linked to genetic make-up

...search. It has been suggested that variants of the dopamine D2 receptor may be related to response to nicotine replacement therapy. This study will be available on bmj.com on Friday 19 March 2004. Researchers examined abstinence from smoking among 752 people, eight years after they had taken part in a trial o...

Single cocaine exposure boosts both drug craving and avoidance

...ventral tegmental area of the brain, or VTA, where dopamine neurons have been shown to be active in learning and memory processes involved in addiction. The drug blocked cocaine's ability to boost morphine's rewarding effect, as well as cocaine's enhancement of an unpleasant effect of another drug, demonstrat...

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