Common heart failure drugs can be safely used at higher, more effective doses, study says
...for a great majority of patients, going from a low dose to a high dose did not cause these severe side effects. "As a rule, giving patients the full recommended dose of A......confirmed among the 5,129 women assigned to either dose of raloxifene, versus 39 cases among the 2,576 women assigned to the placebo. There were no significant differences in outcome between the group taking 60 mg of the drug and those taking 120 mg. Overall, raloxifene was well-tolerated by participants.......he delivery of those services - along with a large dose of hope - to patients and their families and loved ones." Since its inception, the LAF has approved more than $2.5 million in grants. Living Well After Cancer will focus initially on programs for survivors of breast cancer and testicular cancer, two...Science for global health - World Health Day 2001
...ndmark study demonstrated the efficacy of a single dose of the relatively inexpensive drug nevirapine in reducing mother-to-child transmission of HIV, and this regimen is now useful for HIV-positive women presenting at birth without prior antiretroviral therapy. This year's World Health Day theme is Men...Research improves treatment of bladder cancer
...d from the bladder using a catheter. Then, a 20-mg dose of MMC was placed in the bladder, where it was hel...ine acidity. The experimental therapy used a 40-mg dose of MMC and several steps were taken to maintain a high drug concentration in the bladder by reducing...One more visit could close demographic gaps in infant immunization efforts
...percent of the children did not receive the single dose of measles vaccine recommended at age 12-to-15 months. This may leave 85,000 African-American children susceptible to the disease until as late as school entry. POOR LEFT BEHIND When it comes to vaccination coverage, the gap between the h...First effective treatment for gastrointestinal sarcoma seen with multi-center trial of STI-571
.... Half the study participants started with a daily dose of 400 milligrams of STI-571 and half received 600 milligrams daily. Patients on the lower dose whose cancer continued to progress were allowed to switch to the higher dose. An analysis of patient...Early trial at Thomas Jefferson University Hospital shows Angiostatin is safe
...tients increasing doses, beginning at a lower safe dose that is subsequently increased in each successive ... one of five doses spanning a 16-fold range. Each dose was given daily for 10 minutes. The doctors waited 28 days after giving a dose to determine its safe...Smokers more likely to experience impotence, Wake Forest study shows
...vestigators, including finding what doctors call a dose response relationship: the more cigarettes smoked per day the greater the chance of impotence. But most of these earlier studies looked at a highly selective group of patients going to urology or cardiology clinics, he said. "This is the first st...Study shows infliximab can maintain long-term remissions in Crohns disease
...ope, and Israel. All patients received an initial dose of infliximab. The 335 patients (58.5%) who responded to the initial dose were randomized to one of three treatment groups. All three groups received infusions at weeks...... LAB to see if adding the LAB would permit the ICS dose to be reduced or eliminated. The investigators fo...of the LAB permitted a 50 percent reduction in ICS dose without significant loss of asthma control. However, complete elimination of the ICS resulted in a ......n and clarithromycin are taken concomitantly. The dose of clarithromycin should be halved or the dosing interval doubled in patients with severe renal impairment (CrCl<30mL/minute). Pneumonia is an infection or inflammation of the lungs. Community-acquired pneumonia is the most common type of pneumo...New research shows even a single drug exposure can alter brain function
...vestigator Dr. Antonello Bonci, is that the single dose of cocaine usurped a cellular mechanism involved in a normally adaptive learning process, which may help to explain cocaines ability to take control of incentive-motivational systems in the brain and produce compulsive drug-seeking behavior. In addi......ginia Medical School (EVMS) has found that a lower dose of estrogen-progestin combination is effective and safe, while minimizing the bleeding side effect hormone replacement therapy causes in some post-menopausal women. David F. Archer, M.D., professor of obstetrics and gynecology at EVMS' Jones ...Lower dose hormone replacement therapy just as effective as often prescribed doses
... which were comparable to the currently prescribed dose of .625 milligrams of CEE and 2.5 to 5 milligrams ...und to be the most common side effect of the lower dose estrogen regimen. Importantly, however, less bleeding was found with the lower doses. Bleeding is a...Study suggests that potential Alzheimer drugs might be dangerous
...s, they treated cultured thymus lobes with a small dose of inhibitor every 12 hours. After three days, the treated lobes had produced significantly fewer T cells than untreated ones. These results mimic previous observations of thymus cells lacking the appropriate Notch protein. The researchers therefor......everity and mainly confined to the period when the dose was being increased. Other research has shown that when the dose is increased at a slower rate, the occurrence of nausea and vomiting is not significantly greater th...UNC physicians seeking patients for blood clot, medication studies
...nths' regular treatment with a smaller maintenance dose of the drug. Both groups will be monitored for fou... the recurrence of clots," Moll said. "If so, that dose should be the standard of care for patients with a first blood clot." Moll is following 10 patients......ek). The treatment group was prescribed a modified dose by increasing fill volume (to 2.5 or 3L) or by increasing the number of exchanges to 5 daily with 2.5L to achieve a prescription target clearance of 60L per week. Patients enrolled in the study were randomly assigned to the treatment or the contro...New data support the efficacy and safety of the novel oral anticoagulant Exanta
...does not require routine coagulation monitoring or dose adjustment. "There is no doubt that Exanta works well and we are confident about its future" Dr Ian Watts continued. "We are currently committed to carrying out complementary phase III trials of VTE prophylaxis in orthopaedic surgery that will allow...