Interleukin-2 Boosts Cancer Vaccine Effectiveness In Mice
...nclude: Mice injected with three times the lethal dose of tumor (sarcoma) cells andthen vaccinated with a sarcoma-specific dendritic cell vaccine showedsubstantial reduction in tumor size, while mice receiving the same vaccine withIL-2 remained disease free. Eighty percent of mice with well-established ...Morning Coffee Boosts Blood Pressure, Stress Hormones All Day
...er tightly controlled circumstances where a single dose ofcaffeine is compared to none in a short time span. Lane said his body ofresearch is unique because it measures blood pressure, heart rate and stresshormone levels at timed intervals during normal working conditions, whilesubjects are exposed to a r...Acetylcholinesterase Inhibitors May Be Another Piece In Alzheimer's Jigsaw
...overed that the effects of rivastigmine seem to be dose dependent - those patients receiving a higher dose of the drug showed clinically relevant (and statistically significant) improvements. Rsler et al d...Higher Doses Of Methadone May Do The Trick, New Study Says
...es of less than 30 mg, while in others the average dose jumps to 60 mg,Strain says. "Thisprobably stems f... a large number of patients -- 192 -- to amoderate dose group (40 to50 mg of methadone) or to a high dose (80 to 100 mg.) group for the 10-monthtrial. The ...UW-Madison Center One Of Two Sites Nationwide Selected For Clinical Trial Of Cancer Drug
... which researchers will try todiscover the maximum dose patients can tolerate without undue toxicity.Initially, three to six patients will receive small doses of the drug and willbe carefully monitored for toxic effects. Additional patients will then receivegraduated doses of the drug. All patients will b...New Drug For Recurrent Brain Tumors In Tests At UNC
... a slightly lower grade malignancy than GBM. "The dose has been established and this is an open trial. All enrolled will getthe drug, so we can look for evidence of a positive effect against the tumor,"Ewend says. According to the neurosurgeon, anaplastic astrocytoma is very similar to GBM."Patients ma...Study Finds Combining Exercise With Male Hormone Therapy Benefits Men With HIV-Wasting Disease
...developed aprotocol that would incorporate a lower dose of androgen therapy that includedtestosterone and an anabolic steroid," he said. At the beginning of the UCSF study, participants ranged in age from 40-42years and in weight from about 151-161 pounds. Other characteristics includedHIV-pos......agonistdelivered through a device called a metered dose inhaler in the previous threemonths had a 67% increased risk of having a heart attack. Those patients withheart disease had three times the risk of a heart attack; patients with heartdisease who were new users of beta-agonists had seven times the ri...Women May React To General Anesthesia Differently Than Men
... study, even though there was no difference in the dose ofanesthetic used between both groups. The study was designed to keep range of BISbetween 45 and 60, and while that was accomplished, Gan said it is possible thatthe women had a higher BIS score than the men overall. That means the same levelof anest...Retrospective Statistical Analysis Corroborates Early Results Of Randomized Breast Cancer Trials
... other institutions have found no benefitfrom high dose chemotherapy followed by bone marrow transplantati...te patient groups were compared to see if the high dose chemotherapy usedin ABMTR provided any survival benefit for metastatic breast cancer patients. ...New Strategy May Succeed At Extending The Life Of Transplanted Kidneys
... in the majority of patients by cutting inhalf the dose of cyclosporine (Neoral), a widely used drug to prevent rejection, and adding a new anti-rejection drugmycophenolate mofetil (CellCept). The findings will be presented at the AmericanSociety of Transplantation meeting in Chicago on May 16. Although ...Progress In Cancer-Vaccine Studies: Simpler, Safer Approach Producing Encouraging Results
...a new drug, but this trial indicated that the best dose was about onetenth of the maximum dose -- suggesting that dosing trials of biologic therapiesrequire a radically different design. At moder...Sniffing Out The Promise Of Anti-Angiogenesis Therapy
...ays Gill, so that morethan 70 percent of the given dose winds up in the bloodstream. Because thepeptide is destroyed by the stomach, it can't be put into pill form, says Gill."And, obviously, administering the drug through a more convenient route ispreferable," he adds. "Unlike many other cancer drugs tha...Abgenix Reports Positive Survival Data From A Phase II Trial Of ABX-CBL In Graft Versus Host Disease
...lls. The completed trialinvolved patients in four dose cohorts with severe GVHD, an often fatal sideeffec...avorably to a 22% (2 of 9) survival ratein the low dose cohort. Robert Rivkin, M.D. of the Rocky Mountain CancerCenters in Denver, Colorado, presented the ......container was opened and closed, indicating that a dose had been taken. Patients were informed about the monitoring, and agreed to having it done. Theresearch showed a strong link between lapses in dosing and increases in bloodpressure, and overall there was a statistically significant inverse correlatio...Two Beta-Blocker Drugs Equal In Treating Heart Failure
... beta-blockers inheart failure because the initial dose makes the condition worse. Now we knowthat if treatment is initiated very slowly and the dosage is graduallyincreased, the majority of stable heart failure patients can tolerate the drug,"says Kukin. Stable patients are those who are not hospitaliz...ENBREL (Etanercept) Receives FDA Approval For Treatment Of Juvenile Rheumatoid Arthritis
...e of ENBREL for JRA patients is 0.4 mg/kg (maximum dose = 25mg) given twice weekly as a subcutaneous injection 72 - 96 hours apart. Atwo-part clinical trial was conducted in patients ranging from 4 - 17 years ofage with active polyarticular course JRA who were refractory to or intolerant ofmethotrexate t......en whose fathers had accumulated a relatively high dose of ionising radiation (more than 100 millisieverts) before their child's conception was higher than in children conceived before their father's employment in the nuclear industry. However, because this finding was based on only three cases - two of ......ents who received abciximab plus half the standard dose of the clot-buster alteplase (tissue plasminogen activator, or t-PA) achieved optimal blood flow in their arteries within 60 minutes of treatment, compared with only 43 percent of patients treated with alteplase alone. Within 90 minutes, 77 percent ...Circulation publishes phase I study of ENBREL in patients with chronic heart failure
...oration, Seattle WA. The randomized, double-blind dose escalation studyconsisted of 18 patients with New York Heart Association class III heart failureand elevated TNF levels. Patients were randomized to receive a singleintravenous infusion of one of three doses of ENBREL or placebo. Patientsreceiving E...